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Occupational asbestos exposure and risk of esophageal, gastric and colorectal cancer in the prospective Netherlands Cohort Study

Offermans, N.S.M. (author), Vermeulen, R. (author), Burdorf, A. (author), Goldbohm, R.A. (author), Keszei, A.P. (author), Peters, S. (author), Kauppinen, T. (author), Kromhout, H. (author), van den Brandt, P.A. (author)

The evidence for an association between occupational asbestos exposure and esophageal, gastric and colorectal cancer is limited. We studied this association specifically addressing risk differences between relatively low and high exposure, risk associated with cancer subtypes, the influence of potential confounders and the interaction between...

article 2014

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Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer

Kim, D.H. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Yaun, S.S. (author), Colditz, G.A. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Harnack, L. (author), Jacobs, E.J. (author), Leitzmann, M. (author), Mannisto, S. (author), Miller, A.B. (author), Potter, J.D. (author), Rohan, T.E. (author), Schatzkin, A. (author), Speizer, F.E. (author), Stevens, V.L. (author), Stolzenberg-Solomon, R. (author), Terry, P. (author), Toniolo, P. (author), Weijenberg, M.P. (author), Willett, W.C. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Hunter, D.J. (author), TNO Kwaliteit van Leven (author)

Objective: Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. Methods: Study-and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model....

article 2010

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Intakes of vitamins A, C, and e and use of multiple vitamin supplements and risk of colon cancer: A pooled analysis of prospective cohort studies

Park, Y. (author), Spiegelman, D. (author), Hunter, D.J. (author), Albanes, D. (author), Bergkvist, L. (author), Buring, J.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Harnack, L. (author), Kato, I. (author), Krogh, V. (author), Leitzmann, M.F. (author), Limburg, P.J. (author), Marshall, J.R. (author), McCullough, M.L. (author), Miller, A.B. (author), Rohan, T.E. (author), Schatzkin, A. (author), Shore, R. (author), Sieri, S. (author), Stampfer, M.J. (author), Virtamo, J. (author), Weijenberg, M. (author), Willett, W.C. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)

Objective: To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer. Methods: Using the primary data from 13 cohort studies, we estimated study-and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model. Results: Among 676,141 men and...

article 2010

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A compendium of familial relative risks of cancer among first degree relatives: A population-based study

Zeegers, M.P. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)

Familial clustering of cancer is expected to occur at practically all anatomical sites. However, few studies have had sufficient size to investigate different sites simultaneously and with adjustment for confounders. We evaluated familial clustering in the Netherlands Cohort Study in which 120,852 men and women, aged 55-69 years in 1986 were...

article 2008

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Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites

Bongaerts, B.W.C. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), de Goeij, A.F.P.M. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)

Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. Analyses...

article 2008

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Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies

Männistö, S. (author), Yaun, S.S. (author), Hunter, D.J. (author), Spiegelman, D. (author), Adami, H.O. (author), Albanes, D. (author), van den Brandt, P.A. (author), Buring, J.E. (author), Cerhan, J.R. (author), Colditz, G.A. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Harnack, L. (author), Leitzmann, M. (author), McCullough, M.L. (author), Miller, A.B. (author), Rohan, T.E. (author), Schatzkin, A. (author), Virtamo, J. (author), Willett, W.C. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)

Dietary carotenoids have been hypothesized to protect against epithelial cancers. The authors analyzed the associations between intakes of specific carotenoids (alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein + zeaxanthin, and lycopene) and risk of colorectal cancer using the primary data from 11 cohort studies carried out in North...

article 2007

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Dietary fat and risk of colon and rectal cancer with aberrant MLH1 expression, APC or KRAS genes

Weijenberg, M.P. (author), Lüchtenborg, M. (author), de Goeij, A.F.P.M. (author), Brink, M. (author), van Muijen, G.N.P. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)

Objective: To investigate baseline fat intake and the risk of colon and rectal tumors lacking MLH1 (mutL homolog 1, colon cancer, nonpolyposis type 2) repair gene expression and harboring mutations in the APC (adenomatous polyposis coli) tumor suppressor gene and in the KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) oncogene....

article 2007

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Fruits, vegetables, and colon cancer risk in a pooled analysis of 14 cohort studies

Koushik, A. (author), Hunter, D.J. (author), Spiegelman, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Buring, J.E. (author), Calle, E.E. (author), Cho, E. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Giovannucci, E.L. (author), Goldbohm, R.A. (author), Harnack, L. (author), Jacobs Jr., D.R. (author), Kato, I. (author), Krogh, V. (author), Larsson, S.C. (author), Leitzmann, M.F. (author), Marshall, J.R. (author), McCullough, M.L. (author), Miller, A.B. (author), Pietinen, P. (author), Rohan, T.E. (author), Schatzkin, A. (author), Sieri, S. (author), Virtanen, M.J. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)

Background Fruit and vegetable intakes have been associated with a reduced risk of colon cancer; however, in more recent studies associations have been less consistent. Statistical power to examine associations by colon site has been limited in previous studies. Methods Fruit and vegetable intakes in relation to colon cancer risk were examined...

article 2007

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Fruits, vegetables, and hMLH1 protein-deficient and -proficient colon cancer: The Netherlands cohort study

Wark, P.A. (author), Weijenberg, M.P. (author), van 't Veer, P. (author), van Wijhe, G. (author), Luchtenborg, M. (author), van Muijen, G.N.P. (author), de Goeij, A.F.P.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)

Background: Clinical and pathologic differences exist between colon carcinomas deficient and proficient in the mismatch repair protein hMLH1. Animal and in vitro studies suggest that fruits, vegetables, folate, and antioxidants are associated with colonic expression of mismatch repair genes. Methods: Associations between consumption of fruits...

article 2005

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Dietary folate intake and K-ras mutations in sporadic colon and rectal cancer in the Netherlands Cohort Study

Brink, M. (author), Weijenberg, M.P. (author), de Goeij, A.F.P.M. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), de Bruïne, A.P. (author), van Engeland, M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)

We studied the association between dietary folate and specific K-ras mutations in colon and rectal cancer in The Netherlands Cohort Study on diet and cancer. After 7.3 years of follow-up, 448 colon and 160 rectal cancer patients and 3,048 sub-cohort members (55-69 years at baseline) were available for data analyses. Mutation analysis of the K...

article 2005

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Expression profiling of colon cancer cell lines and colon biopsies: Towards a screening system for potential cancer-preventive compounds

van Erk, M.J. (author), Krul, C.A.M. (author), Caldenhoven, E. (author), Stierum, R.H. (author), Peters, W.H. (author), Woutersen, R.A. (author), van Ommen, B. (author), TNO Kwaliteit van Leven TNO Voeding (author)

Interest in mechanisms of colon cancer prevention by food compounds is strong and research in this area is often performed with cultured colon cancer cells. In order to assess utility for screening of potential cancer-preventive (food) compounds, expression profiles of 14 human cell lines derived from colonic tissue were measured using cDNA...

article 2005

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Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: A prospective cohort study (The Netherlands)

Lüchtenborg, M. (author), Weijenberg, M.P. (author), de Goeij, A.F.P.M. (author), Wark, P.A. (author), Brink, M. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van 't Veer, P. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)

Objective: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. Methods: The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort...

article 2005

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Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study

TNO Kwaliteit van Leven TNO Voeding (author), Brink, M. (author), Weijenberg, M.P. (author), de Goeij, A.F.P.M. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)

Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and 2948 subcohort members of The Netherlands Cohort Study on diet and cancer. Adjusted incidence rate ratios and 95% confidence intervals...

article 2005

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Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study

Brink, M. (author), Weijenberg, M.P. (author), de Goeij, A.F.P.M. (author), Schouten, L.J. (author), Koedijk, F.D.H. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding (author)

Associations between dietary intake of various fats and specific K-ras mutations in colorectal cancer (CRC) were investigated within the framework of The Netherlands Cohort Study on diet and cancer (NLCS). After 7.3 years of follow-up and with exclusion of the first 2.3 years, 448 colon and 160 rectal cancer patients and 2948 subcohort members ...

article 2004

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Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells

van Erk, M.J. (author), Teuling, E. (author), Staal, Y.C.M. (author), Huybers, S. (author), van Bladeren, P.J. (author), Aarts, J.M.M.J.G. (author), van Ommen, B. (author), TNO Voeding (author)

Background. Curcumin is a spice and a coloring food compound with a promising role in colon cancer prevention. Curcumin protects against development of colon tumors in rats treated with a colon carcinogen, in colon cancer cells curcumin can inhibit cell proliferation and induce apoptosis, it is an anti-oxidant and it can act as an anti...

article 2004

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Dietary patterns associated with colon and rectal cancer: Results from the Dietary Patterns and Cancer (DIETSCAN) Project

Dixon, L.B. (author), Balder, H.F. (author), Virtanen, M.J. (author), Rashidkhani, B. (author), Männistö, S. (author), Krogh, V. (author), van den Brandt, P.A. (author), Hartman, A.M. (author), Pietinen, P. (author), Tan, F. (author), Virtamo, J. (author), Wolk, A. (author), Goldbohm, R.A. (author), TNO Voeding (author)

Background: An analysis of dietary patterns or combinations of foods may provide insight regarding the influence of diet on the risk of colon and rectal cancer. Objective: A primary aim of the Dietary Patterns and Cancer (DIETSCAN) Project was to develop and apply a common methodologic approach to study dietary patterns and cancer in 4 European...

article 2004

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The role of cyclooxygenase in n-6 and n-3 polyunsaturated fatty acid mediated effects on cell proliferation, PGE2 synthesis and cytotoxicity in human colorectal carcinoma cell lines

Dommels, Y.E.M. (author), Haring, M.M.G. (author), Keestra, N.G.M. (author), Alink, G.M. (author), van Bladeren, P.J. (author), van Ommen, B. (author)

This study was conducted to investigate the role of the enzyme cyclooxygenase (COX) and its prostaglandin product PGE2 in n-6 and n-3 polyunsaturated fatty acid (PUFA)-mediated effects on cellular proliferation of two human colorectal carcinoma cell lines. The long chain PUFAs eicosapentaenoic acid (EPA; 20:5n-3) and arachidonic acid (AA; 20:4n...

article 2003

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Influence of dietary components associated with high or low risk of colon cancer on apoptosis in the rat colon

Hambly, R.J. (author), Saunders, M. (author), Rijken, P.J. (author), Rowland, I.R. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)

Although there is much epidemiological evidence for an interaction between diet and colorectal cancer risk, the mechanisms by which diet might protect against colorectal cancer are still unclear. Here we report the significant up-regulation of carcinogen-induced apoptosis in the colon of rats fed a diet containing low-risk factors for colon...

article 2002

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Functional foods ingredients against colorectal cancer: an example project integrating functional genomics, nutrition and health

TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Stierum, R. (author), Burgemeister, R. (author), van Helvoort, A. (author), Peijnenburg, A. (author), Schütze, K. (author), Seidelin, M. (author), Vang, O. (author), van Ommen, B. (author)

Functional Food Ingredients Against Colorectal Cancer is one of the first European Union funded Research Projects at the cross-road of functional genomics [comprising transcriptomics, the measurement of the expression of all messengers RNA (mRNAs) and proteomics, the measurement of expression/state of all proteins], nutrition and human health....

article 2001

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Vegetable and fruit consumption and risks of colon and rectal cancer in a prospective cohort study

Voorrips, L.E. (author), Goldbohm, R.A. (author), van Poppel, G. (author), Sturmans, F. (author), Hermus, R.J.J. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

The relation between vegetable and fruit consumption and colorectal cancer risk was comprehensively assessed in the Netherlands Cohort Study on Diet and Cancer using a validated 150-item food frequency questionnaire. After 6.3 years of follow-up (1986-1992), over 1,000 incident cases of colorectal cancer were registered. Using case-cohort...

article 2000