Searched for: subject:"Colon"
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Agamennone, V. (author), van Straalen, J. (author), Brouwer, A. (author), de Boer, T.E. (author), Hensbergen, P.J. (author), Zaagman, N. (author), Braster, M. (author), van Straalen, N.M. (author), Roelofs, D. (author), Janssens, T.K.S. (author)
Antibiotic resistance necessitates the search for new bioactive compounds with novel mechanisms of action. Natural products derived from bacteria and fungi are widely used in the field of medicine and new environments can be explored as sources of antimicrobials. Bacteria associated with springtails have shown high inhibitory activity against...
article 2019
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Fehlbaum, S. (author), Prudence, K. (author), Kieboom, J. (author), Heerikhuisen, M. (author), van den Broek, T. (author), Schuren, F.H.J. (author), Steinert, R.E. (author), Raederstorff, D. (author)
Recently, the concept of prebiotics has been revisited to expand beyond non-digestible oligosaccharides, and the requirements for selective stimulation were extended to include microbial groups other than, and additional to, bifidobacteria and lactobacilli. Here, the gut microbiota-modulating effects of well-known and novel prebiotics were...
article 2018
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Zune, Q. (author), Delepierre, A. (author), Gofflot, S. (author), Bauwens, J. (author), Twizere, J.C. (author), Punt, P.J. (author), Francis, F. (author), Toye, D. (author), Bawin, T. (author), Delvigne, F. (author)
Fungal biofilm is known to promote the excretion of secondary metabolites in accordance with solid-staterelated physiological mechanisms. This work is based on the comparative analysis of classical submerged fermentation with a fungal biofilmreactor for the production of a Gla::green fluorescent protein (GFP) fusion protein by Aspergillus oryzae...
article 2015
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Mariman, R. (author), Tielen, F. (author), Koning, F. (author), Nagelkerken, L. (author)
Background: Probiotic bacteria may render mice resistant to the development of various inflammatory and infectious diseases. Objective: This study aimed to identify mechanisms by which probiotic bacteria may influence intestinal immune homeostasis in noninflammatory conditions. Methods: The effect of VSL#3, a mixture of 8 probiotic bacteria, on...
article 2015
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Vogt, L.M. (author), Meyer, D. (author), Pullens, G. (author), Faas, M.M. (author), Venema, K. (author), Ramasamy, U. (author), Schols, H.A. (author), de Vos, P. (author)
Dietary fiber intake is associated with lower incidence and mortality from disease, but the underlying mechanisms of these protective effects are unclear.We hypothesized that β2→1-fructan dietary fibers confer protection on intestinal epithelial cell barrier function via Toll-like receptor 2 (TLR2), and we studied whether β2→1-fructan chain...
article 2014
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Offermans, N.S.M. (author), Vermeulen, R. (author), Burdorf, A. (author), Goldbohm, R.A. (author), Keszei, A.P. (author), Peters, S. (author), Kauppinen, T. (author), Kromhout, H. (author), van den Brandt, P.A. (author)
The evidence for an association between occupational asbestos exposure and esophageal, gastric and colorectal cancer is limited. We studied this association specifically addressing risk differences between relatively low and high exposure, risk associated with cancer subtypes, the influence of potential confounders and the interaction between...
article 2014
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Ramasamy, U.S. (author), Venema, K. (author), Gruppen, H. (author), Schols, H.A. (author)
The aim of this study was to monitor cell wall polysaccharide (CWPs) utilization during fermentation by the human colonic microbiota in the TNO in vitro model of the colon (TIM-2). Chicory root pulp (CRP) and treated (ensiled) CRP (ECRP) containing four times more soluble pectin than CRP, were fermented in the model. After the adaptation phase...
article 2014
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Zaura, E. (author), Nicu, E.A. (author), Krom, B.P. (author), Keijser, B.J. (author)
The oral microbiota survives daily physical and chemical perturbations from the intake of food and personal hygiene measures, resulting in a long-term stable microbiome. Biological properties that confer stability in the microbiome are important for the prevention of dysbiosis-a microbial shift toward a disease, e.g., periodontitis or caries....
article 2014
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de Oliveira, J.E. (author), van der Hoeven-Hangoor, E. (author), van de Linde, I.B. (author), Montijn, R.C. (author), van der Vossen, J.M.B.M. (author)
The feasibility of establishing probiotic bacteria in the intestine of broiler chickens by in ovo inoculation was investigated, followed by verifying possible subsequent protection against Salmonella Enteriditis infection. In a first study, 7 commercially available probiotics were screened for compatibility with in ovo inoculation. Two of these...
article 2014
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Belzer, C. (author), Gerber, G.K. (author), Roeselers, G. (author), Delaney, M. (author), DuBois, A. (author), Liu, Q. (author), Belavusava, V. (author), Yeliseyev, V. (author), Houseman, A. (author), Onderdonk, A. (author), Cavanaugh, C. (author), Bry, L. (author)
Longitudinal studies of the microbiota are important for discovering changes in microbial communities that affect the host. The complexity of these ecosystems requires rigorous integrated experimental and computational methods to identify temporal signatures that promote physiologic or pathophysiologic responses in vivo. Employing a murine model...
article 2014
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Simons, C.C.J.M. (author), Hughes, L.A.E. (author), van Engeland, M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Weijenberg, M.P. (author)
We investigated occupational energy expenditure and sitting time in the longest held job (in men only), nonoccupational physical activity, and former sports participation in relation to colorectal cancer endpoints. The Netherlands Cohort Study includes 120,852 participants who completed a self-administered questionnaire in 1986 when they were...
article 2013
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Mariman, R. (author), Kremer, S.H.A. (author), van Erk, M. (author), Lagerweij, T. (author), Koning, F. (author), Nagelkerken, L. (author)
Background: Host-microbiota interactions in the intestinal mucosa play a major role in intestinal immune homeostasis and control the threshold of local inflammation. The aim of this study was to evaluate the efficacy of probiotics in the recurrent trinitrobenzene sulfonic acid (TNBS)-induced colitis model and gain more insight into protective...
article 2012
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Hughes, L.A.E. (author), Simons, C.C.J.M. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), van Engeland, M. (author), Weijenberg, M.P. (author)
A large body size may differentially influence risk of colorectal cancer (CRC) by anatomic location. The Netherlands Cohort Study includes 120,852 men and women aged 55-69 years who self-reported weight, height, and trouser/skirt size at baseline (1986), as well as weight at age 20 years. Derived variables included body mass index (BMI; weight ...
article 2011
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Kim, D.H. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Yaun, S.S. (author), Colditz, G.A. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Harnack, L. (author), Jacobs, E.J. (author), Leitzmann, M. (author), Mannisto, S. (author), Miller, A.B. (author), Potter, J.D. (author), Rohan, T.E. (author), Schatzkin, A. (author), Speizer, F.E. (author), Stevens, V.L. (author), Stolzenberg-Solomon, R. (author), Terry, P. (author), Toniolo, P. (author), Weijenberg, M.P. (author), Willett, W.C. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Hunter, D.J. (author), TNO Kwaliteit van Leven (author)
Objective: Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. Methods: Study-and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model....
article 2010
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Park, Y. (author), Spiegelman, D. (author), Hunter, D.J. (author), Albanes, D. (author), Bergkvist, L. (author), Buring, J.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Harnack, L. (author), Kato, I. (author), Krogh, V. (author), Leitzmann, M.F. (author), Limburg, P.J. (author), Marshall, J.R. (author), McCullough, M.L. (author), Miller, A.B. (author), Rohan, T.E. (author), Schatzkin, A. (author), Shore, R. (author), Sieri, S. (author), Stampfer, M.J. (author), Virtamo, J. (author), Weijenberg, M. (author), Willett, W.C. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)
Objective: To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer. Methods: Using the primary data from 13 cohort studies, we estimated study-and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model. Results: Among 676,141 men and...
article 2010
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Simons, C.C.J.M. (author), Hughes, L.A.E. (author), Arts, I.C.W. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)
Dietary flavonoids are hypothesized to be protective against colorectal cancer, yet findings have been inconsistent. We examined the association of dietary flavonol, flavone and catechin intake with colorectal cancer endpoints within the Netherlands Cohort Study (NLCS). In addition, we explored whether body mass index (BMI) may be an effect...
article 2009
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Rijsdijk, K.F. (author), Hume, J.P. (author), Bunnik, F. (author), Florens, F.B.V. (author), Baider, C. (author), Shapiro, B. (author), van der Plicht, J. (author), Janoo, A. (author), Griffiths, O. (author), van den Hoek Ostende, L.W. (author), Cremer, H. (author), Vernimmen, T. (author), de Louw, P.G.B. (author), Bholah, A. (author), Saumtally, S. (author), Porch, N. (author), Haile, J. (author), Buckley, M. (author), Collins, M. (author), Gittenberger, E. (author), TNO Bouw en Ondergrond (author)
Although the recent history of human colonisation and impact on Mauritius is well documented, virtually no records of the pre-human native ecosystem exist, making it difficult to assess the magnitude of the changes brought about by human settlement. Here, we describe a 4000-year-old fossil bed at Mare aux Songes (MAS) in south-eastern Mauritius...
article 2009
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Hamer, H.M. (author), Jonkers, D.M.A.E. (author), Loof, A. (author), van Houtvin, S.A.L.W. (author), Troost, F.J. (author), Venema, K. (author), Kodde, A. (author), Koek, G.H. (author), Schipper, R.G. (author), van Heerde, W.L. (author), Brummer, R.J. (author), TNO Kwaliteit van Leven (author)
Background: The mucus layer is an important dynamic component of the epithelial barrier. It contains mucin glycoproteins and other compounds secreted by the intestinal epithelium, such as secretory IgA. However, a standardized in vivo sampling technique of mucus in humans is not yet available. Aim: To assess the validity and feasibility of mucin...
article 2009
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Zeegers, M.P. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Familial clustering of cancer is expected to occur at practically all anatomical sites. However, few studies have had sufficient size to investigate different sites simultaneously and with adjustment for confounders. We evaluated familial clustering in the Netherlands Cohort Study in which 120,852 men and women, aged 55-69 years in 1986 were...
article 2008
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Bongaerts, B.W.C. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), de Goeij, A.F.P.M. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)
Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. Analyses...
article 2008
Searched for: subject:"Colon"
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