Searched for: subject:"Collagen"
(1 - 20 of 129)

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Ruiz-Zapata, A.M. (author), Heinz, A. (author), Kerkhof, M.H. (author), van de Westerlo-van Rijt, C. (author), Schmelzer, C.E.H. (author), Stoop, R. (author), Kluivers, K.B. (author), Oosterwijk, E. (author)
Fibroblast to myofibroblast differentiation is a key feature of wound-healing in soft tissues, including the vagina. Vaginal fibroblasts maintain the integrity of the vaginal wall tissues, essential to keep pelvic organs in place and avoid pelvic organ prolapse (POP). The micro-environment of vaginal tissues in POP patients is stiffer and has...
article 2020
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Bongers, C.C.W.G. (author), ten Haaf, D.S.M. (author), Catoire, M. (author), Kersten, B. (author), Wouters, J.A. (author), Eijsvogels, T.M.H. (author), Hopman, M.T.E. (author)
The purpose of this study was to examine the effects of 12 weeks collagen peptide (CP) supplementation on knee pain and function in individuals with self-reported knee pain. Healthy physically active individuals (n = 167, aged 63 [interquartile range = 56-68] years) with self-reported knee pain received 10 g/day of CP or placebo for 12 weeks....
article 2020
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Mirahmadi, F. (author), Koolstra, J.H. (author), Fazaeli, S. (author), Lobbezoo, F. (author), van Lenthe, G.H. (author), Snabel, J. (author), Stoop, R. (author), Everts, V. (author)
Nutrition of articular cartilage relies mainly on diffusion and convection of solutes through the interstitial fluid due to the lack of blood vessels. The diffusion is controlled by two factors: steric hindrance and electrostatic interactions between the solutes and the matrix components. Aging comes with changes in the cartilage structure and...
article 2019
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He, M. (author), Harms, A.C. (author), van Wijk, E. (author), Wang, M. (author), Berger, R. (author), Koval. S., (author), Hankemeier, T. (author), van der Greef, J. (author)
Background. Rheumatoid arthritis (RA) is a complex, chronic autoimmune disease characterized by various inflammatory symptoms, including joint swelling, joint pain, and both structural and functional joint damage. The most commonly used animal model for studying RA is mice with collagen‐induced arthritis (CIA); the wide use of this model is due...
article 2019
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Mirahmadi, F. (author), Koolstra, J.H. (author), Lobbezoo, F. (author), van Lenthe, G.H. (author), Ghazanfari, S. (author), Snabel, J. (author), Stoop, R. (author), Everts, V. (author)
Objective: Aging is accompanied by a series of changes in mature tissues that influence their properties and functions. Collagen, as one of the main extracellular components of cartilage, becomes highly crosslinked during aging. In this study, the aim was to examine whether a correlation exists between collagen crosslinking induced by artificial...
article 2018
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Pouran, B. (author), Moshtagh, P.R. (author), Arbabi, V. (author), Snabel, J. (author), Stoop, R. (author), Ruberti, J. (author), Malda, J. (author), Zadpoor, A.A. (author), Weinans, H. (author)
An important aspect in cartilage ageing is accumulation of advanced glycation end products (AGEs) after exposure to sugars. Advanced glycation results in cross-links formation between the collagen fibrils in articular cartilage, hampering their flexibility and making cartilage more brittle. In the current study, we investigate whether collagen...
article 2018
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He, M. (author), van Wijk, E. (author), van Wietmarschen, H. (author), Wang, M. (author), Sun, M. (author), Koval, S. (author), van Wijk, R. (author), Hankemeier, T. (author), van der Greef, J. (author)
The increasing prevalence of rheumatoid arthritis has driven the development of new approaches and technologies for investigating the pathophysiology of this devastating, chronic disease. From the perspective of systems biology, combining comprehensive personal data such as metabolomics profiling with ultra-weak photon emission (UPE) data may...
article 2017
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Sasaki, T. (author), Stoop, R. (author), Sakai, T. (author), Hess, A. (author), Deutzmann, R. (author), Schlötzer-Schrehardt, U. (author), Chu, M.L. (author), von der Mark, K. (author)
The extracellular matrix protein fibulin-4 has been shown to be indispensable for elastic fiber assembly, but there is also evidence from human mutations that it is involved in controlling skeletal development and bone stability. Fibulin-4 mutations were identified in patients suffering from vascular abnormality and/or cutis laxa, and some of...
article 2016
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González-Santamaría, J. (author), Villalba, M. (author), Busnadiego, O. (author), López-Olañeta, M.M. (author), Sandoval, P. (author), Snabel, J. (author), López-Cabrera, M. (author), Erler, J.T. (author), Hanemaaijer, R. (author), Lara-Pezzi, E. (author), Rodríguez-Pascual, F. (author)
Aims After myocardial infarction (MI), extensive remodelling of the extracellular matrix contributes to scar formation. While aiming to preserve tissue integrity, this fibrotic response is also associated with adverse events, including a markedly increased risk of heart failure, ventricular arrhythmias, and sudden cardiac death. Cardiac fibrosis...
article 2016
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Busnadiego, O. (author), Gorbenko del Blanco, D. (author), González-Santamaría, J. (author), Habashi, J.P. (author), Calderon, J.F. (author), Sandoval, P. (author), Bedja, D. (author), Guinea-Viniegra, J. (author), Lopez-Cabrera, M. (author), Rosell-Garcia, T. (author), Snabel, J.M. (author), Hanemaaijer, R. (author), Forteza, A. (author), Dietz, H.C. (author), Egea, G. (author), Rodriguez-Pascual, F. (author)
Patients with Marfan syndrome (MFS) are at high risk of life-threatening aortic dissections. The condition is caused by mutations in the gene encoding fibrillin-1, an essential component in the formation of elastic fibers. While experimental findings in animal models of the disease have shown the involvement of transforming growth factor-β (TGF...
article 2015
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He, M. (author), van Wijk, E. (author), Berger, R. (author), Wang, M. (author), Strassburg, K. (author), Schoeman, J.C. (author), Vreeken, R.J. (author), van Wietmarschen, H. (author), Harms, A.C. (author), Kobayashi, M. (author), Hankemeier, T. (author), van der Greef, J. (author)
Oxylipins play important roles in various biological processes and are considered as mediators of inflammation for a wide range of diseases such as rheumatoid arthritis (RA). The purpose of this research was to study differences in oxylipin levels between a widely used collagen induced arthritis (CIA) mice model and healthy control (Ctrl) mice....
article 2015
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Willems, N.M.B.K. (author), Langenbach, G.E.J. (author), Stoop, R. (author), den Toonder, J.M.J. (author), Mulder, L. (author), Zentner, A. (author), Everts, V. (author)
The role of mature collagen cross-links, pentosidine (Pen) cross-links in particular, in the micromechanical properties of cancellous bone is unknown. The aim of this study was to examine nonenzymatic glycation effects on tissue stiffness of demineralized and non-demineralized cancellous bone. A total of 60 bone samples were derived from...
article 2014
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Blaauboer, M.E. (author), Boeijen, F.R. (author), Emson, C.L. (author), Turner, S.M. (author), Zandieh-Doulabi, B. (author), Hanemaaijer, R. (author), Smit, T.H. (author), Stoop, R. (author), Everts, V. (author)
Lung fibrosis is characterized by excessive deposition of extracellular matrix. This not only affects tissue architecture and function, but it also influences fibroblast behavior and thus disease progression. Here we describe the expression of elastin, type V collagen and tenascin C during the development of bleomycin-induced lung fibrosis. We...
article 2014
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Kerkhof, M.H. (author), Ruiz-Zapata, A.M. (author), Bril, H. (author), Bleeker, M.C.G. (author), Belien, J.A.M. (author), Stoop, R. (author), Helder, M.N. (author)
Objective The objective of this study was to compare histological and biochemical features of the (normal) precervical anterior vaginal wall and the prolapsed anterior vaginal wall of women with pelvic organ prolapse (POP). These data were compared to tissue of the precervical anterior vaginal wall of age-matched controls without POP to identify...
article 2014
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Kühnast, S. (author), van der Hoorn, J.W.A. (author), Pieterman, E.J. (author), van den Hoek, A.M. (author), Sasiela, W.J. (author), Gusarova, V. (author), Peyman, A. (author), Schäfer, H.L. (author), Schwahn, U. (author), Jukema, J.W. (author), Princen, H.M.G. (author)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is a potential novel strategy for treatment of CVD. Alirocumab is a fully human PCSK9 monoclonal antibody in phase 3 clinical development. We evaluated the antiatherogenic potential of alirocumab in APOE∗3Leiden. CETP mice. Mice received a Western-type diet and were treated with...
article 2014
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Blaauboer, M.E. (author), Emson, C.L. (author), Verschuren, L. (author), van Erk, M. (author), Turner, S.M. (author), Everts, V. (author), Hanemaaijer, R. (author), Stoop, R. (author)
Collagen deposition is a key process during idiopathic pulmonary fibrosis; however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily available and it is difficult to identify changes in collagen content, since standard collagen analyses do not...
article 2013
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Willems, N.M.B.K. (author), Mulder, L. (author), Bank, R.A. (author), Grünheid, T. (author), den Toonder, J.M.J. (author), Zentner, A. (author), Langenbach, G.E.J. (author)
Although bone-tissue stiffness is closely related to the degree to which bone has been mineralized, other determinants are yet to be identified. We, therefore, examined the extent to which the mineralization degree, collagen, and its cross-links are related to bone-tissue stiffness. A total of 50 cancellous and cortical bone samples were derived...
article 2011
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Lindeman, J.H.N. (author), Ashcroft, B.A. (author), Beenakker, J.-W.M. (author), van Es, M. (author), Koekkoek, N.B.R. (author), Prins, F.A. (author), Tielemans, J.F. (author), Abdul-Hussien, H. (author), Bank, R.A. (author), Oosterkamp, T.H. (author), TNO Kwaliteit van Leven (author)
An aneurysm of the aorta is a common pathology characterized by segmentalweakeningof the artery.Althoughit isgenerally accepted that the vessel-wall weakening is caused by an impaired collagen metabolism, a clear association has been demonstrated only for rare syndromes such as the vascular type Ehlers-Danlos syndrome. Here we show that vessel...
article 2010
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Willems, N.M.B.K. (author), Langenbach, G.E.J. (author), Everts, V. (author), Mulder, L. (author), Grünheid, T. (author), Bank, R.A. (author), Zentner, A. (author), van Eijden, T.M.G.J. (author), TNO Kwaliteit van Leven (author)
Collagen is an important constituent of bone, and it has been suggested that changes in collagen and mineral properties of bone are interrelated during growth. The aim of this study was to quantify age-related changes in collagen properties and the degree of mineralization of bone (DMB). The DMB in cancellous and cortical bone samples from the...
article 2010
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van de Briel, R.J. (author), Pennings, J.L.A. (author), Baken, K.A. (author), Pronk, T.E. (author), Boorsma, A. (author), Gottschalk, R. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
Many chemicals can induce allergic contact dermatitis. Because evaluation of skin sensitizing potential by animal testing is prohibited for cosmetics, and screening of many chemicals is required within Registration, Evaluation, Authorisation and Restriction of Chemicals, urgent need exists for predictive in vitro assays to identify contact...
article 2010
Searched for: subject:"Collagen"
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