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Shankar, K. (author), Pivik, R.T. (author), Johnson, S.L. (author), van Ommen, B. (author), Demmer, E. (author), Murray, R. (author)Understanding health requires more than knowledge of the genome. Environmental factors regulate gene function through epigenetics. Collectively, environmental exposures have been called the "exposome." Caregivers are instrumental in shaping exposures in a child's initial years. Maternal dietary patterns, physical activity, degree of weight gain,...article 2018
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de Kleine, M.J.K. (author), den Ouden, A.L. (author), Kollée, L.A.A. (author), van der Nijhuis - Sanden, M.W.G. (author), Sondaar, M. (author), Kessel van - Feddema, B.J.M. (author), Knuijt, S. (author), van Baar, A.L. (author), Ilsen, A. (author), Breur-Pieterse, R. (author), Briët, J.M. (author), Brand, R. (author), Verloove-Vanhorick, S.P. (author)Background: Long term follow up shows a high frequency of developmental disturbances in preterm survivors of neonatal intensive care formerly considered non-disabled. Aims: To develop and validate an assessment tool that can help paediatricians to identify before 6 years of age which survivors have developmental disturbances that may interfere...article 2003
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Huijbregts, S.C.J. (author), de Sonneville, L.M.J. (author), Licht, R. (author), van Spronsen, F.J. (author), Verkerk, P.H. (author), Sergeant, J.A. (author)Fifty-seven 7-14-year-old early- and continuously treated phenylketonuria (PKU) patients and 65 matched controls performed a sustained attention task. PKU patients with plasma phenylalanine (phe) levels higher than 360 μmol/l at the time of testing exhibited, compared to controls, lower speed of information processing, a lower ability to inhibit...article 2002