Searched for: subject:"Cognition%5C+Disorders"
(1 - 13 of 13)
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Mulder, S.D. (author), van der Flier, W.M. (author), Verheijen, J.H. (author), Mulder, C. (author), Scheltens, P. (author), Blankenstein, M.A. (author), Hack, C.E. (author), Veerhuis, R. (author), TNO Kwaliteit van Leven (author)
Several studies have shown that reduced amyloid-β 1-42 (Aβ {42}) and increased tau levels in cerebrospinal fluid (CSF) reflect increased Alzheimer's disease (AD) pathology in the brain. β-site APP cleaving enzyme (BACE1) is thought to be the major β-secretase involved in Aβ production in the brain, and therefore we investigated the relation...
article 2010
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van den Berg, J.F. (author), van Rooij, F.J.A. (author), Vos, H. (author), Tulen, J.H.M. (author), Hofman, A. (author), Miedema, H.M.E. (author), Neven, A.K. (author), Tiemeier, H. (author), TNO Bouw (author)
Sleep duration is an important concept in epidemiological studies. It characterizes a night's sleep or a person's sleep pattern, and is associated with numerous health outcomes. In most large studies, sleep duration is assessed with questionnaires or sleep diaries. As an alternative, actigraphy may be used, as it objectively measures sleep...
article 2008
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van Uffelen, J.G.Z. (author), Chinapaw, M.J.M. (author), van Mechelen, W. (author), Hopman-Rock, M. (author), TNO Kwaliteit van Leven (author)
Objective: To examine the effects of aerobic exercise or vitamin B supplementation on cognitive function in older adults with mild cognitive impairment (MCI). Design: Randomised placebo-controlled trial. Setting: General community. Participants: Community-dwelling adults aged 70-80 with MCI. Interventions : The 152 participants were randomly...
article 2008
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Hille, E.T.M. (author), Weisglas-Kuperus, N. (author), van Goudoever, J.B. (author), Jacobusse, G.W. (author), Ens-Dokkum, M.H. (author), de Groot, L. (author), Wit, J.M. (author), Geven, W.B. (author), Kok, J.H. (author), de Kleine, M.J.K. (author), Kollée, L.A.A. (author), Mulder, A.L.M. (author), van Straaten, H.L.M. (author), de Vries, L.S. (author), van Weissenbruch, M.M. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE. Young adults who were born very preterm or with a very low birth weight remain at risk for physical and neurodevelopmental problems and lower academic achievement scores. Data, however, are scarce, hospital based, mostly done in small populations, and need additional confirmation. METHODS. Infants who were born at <32 weeks of...
article 2007
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van Uffelen, J.G.Z. (author), Chin A Paw, M.J.M. (author), Hopman-Rock, M. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)
Objectives: To examine the effect of walking and vitamin B supplementation on quality-of-life (QoL) in community-dwelling adults with mild cognitive impairment. Methods: One year, double-blind, placebo-controlled trial. Participants were randomized to: (1) twice-weekly, group-based, moderate-intensity walking program (n = 77) or a light...
article 2007
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Mooijaart, S.P. (author), van Vliet, P. (author), van Heemst, D. (author), Rensen, P.C.N. (author), Berbée, J.F.P. (author), Jolles, J. (author), de Craen, A.J.M. (author), Westendorp, R.G.J. (author), TNO Kwaliteit van Leven (author)
The relationship between structural variants of the apolipoprotein E gene, APOE ε2/ε3/ε4, and dementia is well established, whereas the relationship of plasma apoE levels with dementia is less clear. Plasma apoE levels are under tight genetic control but vary widely within the various genotypes indicating that the APOE ε2/ε3/ε4 locus explains...
bookPart 2007
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Huijbregts, S.C.J. (author), de Sonneville, L.M.J. (author), Licht, R. (author), van Spronsen, F.J. (author), Verkerk, P.H. (author), Sergeant, J.A. (author)
Fifty-seven 7-14-year-old early- and continuously treated phenylketonuria (PKU) patients and 65 matched controls performed a sustained attention task. PKU patients with plasma phenylalanine (phe) levels higher than 360 μmol/l at the time of testing exhibited, compared to controls, lower speed of information processing, a lower ability to inhibit...
article 2002
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Hopman-Rock, M. (author), Staats, P.G.M. (author), Tak, E.C.P.M. (author), Dröes, R.M. (author), TNO Preventie en Gezondheid (author)
Objectives. To test the effects of the Psychomotor Activation Programme (PAP) on the behaviour and cognition of demented elderly people. Design. Randomized controlled trial with an experimental group and a control group. Post-test after 6 months. Setting. Group care projects for demented elderly people living in 11 different homes for the...
article 1999
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Slooter, A.J.C. (author), van Duijn, C.M. (author), Bots, M.L. (author), Ott, A. (author), Breteler, M.B. (author), de Voecht, J. (author), Wehnert, A. (author), de Knijff, P. (author), Havekes, L.M. (author), Grobbee, D.E. (author), van Broeckhoven, C. (author), Hofman, A. (author), Gaubius Instituut TNO (author)
The apolipoprotein E4 allele (APOEε4) and atherosclerosis are risk factors for cognitive decline. We investigated whether the effects of APOEε4 and atherosclerosis on cognitive decline are independent. A population-based follow-up study was performed on 838 subjects who were non-demented at baseline. The Mini Mental State Examination (MMSE)...
article 1998
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de Koning, I. (author), van Kooten, F. (author), Dippel, D.W.J. (author), van Harskamp, F. (author), Grobbee, D.E. (author), Kluft, C. (author), Koudstaal, P.J. (author), Gaubius instituut TNO (author)
Background and Purpose - Most mental screening tests focus on the detection of cognitive deficits compatible with Alzheimer's disease. Stroke patients who develop a dementia syndrome, however, constitute a more heterogeneous group with both cortical and subcortical disturbances. We assessed the diagnostic accuracy of the CAMCOG (the cognitive...
article 1998
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Eekhof, J.A.H. (author), de Bock, G.H. (author), Schaapveld, K. (author), Perenboom, R.J.M. (author), Springer, M.P. (author), TNO Preventie en Gezondheid (author)
Objective. To determine which age-related disorders lend themselves for screening followed by intervention in general practice. Setting. Department of General Practice Medicine, University of Leiden. Design. Descriptive. Methods. This study concerned eight frequent age-related disorders: auditory and visual disorders, cognitive limitations,...
article 1996
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Feskens, E.J.M. (author), Havekes, L.M. (author), Kalmijn, S. (author), de Knijff, P. (author), Launer, L.J. (author), Kromhout, D. (author), TNO Preventie en Gezondheid (author)
Objectives - To determine whether polymorphism of apolipoprotein E - notably, the e4 allele - predicts cognitive deterioration in the general population. Design - Population based cohort investigated in 1990 and in 1993. Setting - Zutphen, the Netherlands. Subjects - Representative cohort of 538 Dutch men aged 70-89 at baseline. Main outcome...
article 1994
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Smits, R.C.F. (author), Emmen, H.H. (author), Bertelmans, F.W. (author), Kulig, B.M. (author), van Loenen, A.C. (author), Polman, C.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could...
article 1994
Searched for: subject:"Cognition%5C+Disorders"
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