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Systems approach for classifying the response to biological therapies in patients with rheumatoid arthritis in clinical practice

Fu, J. (author), van Wietmarschen, H.A. (author), van der Kooij, A. (author), Cuppen, B.V.J. (author), Schroën, Y. (author), Marijnissen, A.K. (author), Meulman, J.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)

Introduction: Biological therapies have greatly improved the treatment efficacy in rheumatoid arthritis (RA). However, in clinical practice a significant proportion of patients experience an inadequate response to treatment. The aim of this study is to classify responding and non-responding rheumatoid arthritis patients treated with biological...

article 2018

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Quantifying the burden of stillbirths before 28 weeks of completed gestational age in high-income countries: A population-based study of 19 European countries

Smith, L.K. (author), Hindori-Mohangoo, A.D. (author), Delnord, M. (author), Durox, M. (author), Szamotulska, K. (author), Macfarlane, A. (author), Barros, H. (author), Gissler, M. (author), Blondel, B. (author), Zeitlin, J. (author)

Background. International comparisons of stillbirth allow assessment of variations in clinical practice to reduce mortality. Currently, such comparisons include only stillbirths from 28 or more completed weeks of gestational age, which underestimates the true burden of stillbirth. With increased registration of early stillbirths in high-income...

article 2018

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Questionnaires used to assess barriers of clinical guideline use among physicians are not comprehensive, reliable, or valid: a scoping review

Willson, M.L. (author), Vernooij, R.W.M. (author), Gagliardi, A.R. (author), Armstrong, M. (author), Bernhardsson, S. (author), Brouwers, M. (author), Bussières, A. (author), Fleuren, M.A.H. (author), Gali, K. (author), Huckson, S. (author), Jones, S. (author), Lewis, S.Z. (author), James, R. (author), Marshall, C. (author), Mazza, D. (author)

Objective This study described the number and characteristics of questionnaires used to assess barriers of guideline use among physicians. Study Design and Setting A scoping review was conducted. MEDLINE and EMBASE were searched from 2005 to June 2016. English-language studies that administered a questionnaire to assess barriers of guideline use...

article 2017

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Bridging the translational innovation gap through good biomarker practice

van Gool, A.J. (author), Bietrix, F. (author), Caldenhoven, E. (author), Zatloukal, K. (author), Scherer, A. (author), Litton, J.E. (author), Meijer, G. (author), Blomberg, N. (author), Smith, A. (author), Mons, B. (author), Heringa, J. (author), Koot, W.J. (author), Smit, M.J. (author), Hajduch, M. (author), Rijnders, T. (author), Ussi, A. (author)

[No abstract available] Chemicals / CAS Biomarkers.

article 2017

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Systems biology of personalized nutrition

van Ommen, B. (author), van den Broek, T. (author), de Hoogh, I. (author), van Erk, M. (author), van Someren, E. (author), Rouhani-Rankouhi, T. (author), Anthony, J.C. (author), Hogenelst, K. (author), Pasman, W. (author), Boorsma, A. (author), Wopereis, S. (author)

Personalized nutrition is fast becoming a reality due to a number of technological, scientific, and societal developments that complement and extend current public health nutrition recommendations. Personalized nutrition tailors dietary recommendations to specific biological requirements on the basis of a person’s health status and goals. The...

article 2017

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Characterizing patient-oriented tools that could be packaged with guidelines to promote self-management and guideline adoption: A meta-review

Vernooij, R.W.M. (author), Willson, M. (author), Gagliardi, A.R. (author), Armstrong, M. (author), Brouwers, M. (author), Bussières, A. (author), Fleuren, M. (author), Gali, K. (author), Huckson, S. (author), Jones, S. (author), Lewis, S.Z. (author), James, R. (author), Marshall, C. (author), Mazza, D. (author)

Background: Self-management is an important component of care for patients or consumers (henceforth termed patients) with chronic conditions. Research shows that patients view guidelines as potential sources of self-management support. However, few guidelines provide such support. The primary purpose of this study was to characterize effective...

article 2016

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A systematic approach to implementing and evaluating clinical guidelines: The results of fifteen years of Preventive Child Health Care guidelines in the Netherlands

Fleuren, M.A.H. (author), van Dommelen, P. (author), Dunnink, T. (author)

Preventive Child Health Care (PCHC) services are delivered to all children in the Netherlands by approximately 5500 doctors, nurses and doctor's assistants. In 1996, The Dutch Ministry of Health, Welfare and Sports asked for the development of evidence-based PCHC guidelines. Since 1998, twenty-five guidelines have been published. Levels of...

article 2015

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Jeugdgezondheidszorgrichtlijn 'Zindelijkheid urine en feces' [Guideline 'Incontinence urine and feces' of the Dutch Preventive Youth Health Care]

Beltman, M. (author), Deurloo, J.A. (author), van Leerdam, F.J.M. (author), Wierenga-van der Hoeven, C.J. (author), Bulk-Bunschoten, A.M.W. (author), Kamphuis, M. (author)

Continence problems can occur during childhood. This guideline is for the Dutch Youth Health Care (JGZ) and gives recommendations for the prevention, early detection and treatment of these problems. As a preventative measure advices for potty training should be started in children aged 18-24 months. If incontinence is present, it is important to...

article 2012

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Reproducibility and validity of the Dutch translation of the de Morton Mobility Index (DEMMI) used by physiotherapists in older patients with knee or Hip osteoarthritis

Jans, M.P. (author), Slootweg, V.C. (author), Boot, C.R. (author), de Morton, N.A. (author), van der Sluis, G. (author), van Meeteren, N.L. (author)

Objective: To examine the reproducibility, construct validity, and unidimensionality of the Dutch translation of the de Morton Mobility Index (DEMMI), a performance-based measure of mobility for older patients. Design: Cross-sectional study. Setting: Rehabilitation center (reproducibility study) and hospital (validity study). Participants:...

article 2011

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Pregnancy and labour in the dutch maternity care system: What is normal? The role division between midwives and obstetricians

Amelink-Verburg, M.P. (author), Buitendijk, S.E. (author), TNO Kwaliteit van Leven (author)

Introduction: In the Dutch maternity care system, the role division between independently practising midwives (who take care of normal pregnancy and childbirth) and obstetricians (who care for pathologic pregnancy and childbirth) has been established in the so-called " List of Obstetric Indications" (LOI). The LOI designates the most appropriate...

article 2010

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Jgz-richtlijn: 'Signalering van en verwijscriteria bij kleine lichaamslengte' [Guideline for preventive child health care: 'Detection and referral criteria in short stature']

Kamphuis, M. (author), Obenhuijsen, N.H. (author), van Dommelen, P. (author), van Buuren, S. (author), Verkerk, P.H. (author), TNO Kwaliteit van Leven (author)

The main goal of this guideline for preventive child health care (PCHC) is to improve early detection of disorders that induce short stature. Based on research, evidence-based referral criteria for children aged 0-10 years with a short stature were formulated. These criteria are important for all professionals working with children, such as PCHC...

article 2010

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Asthma beliefs among mothers and children from different ethnic origins living in Amsterdam, the Netherlands

TNO Kwaliteit van Leven (author), van Dellen, Q.M. (author), van Aalderen, W.M.C. (author), Bindels, P.J.E. (author), Öry, F.G. (author), Bruil, J. (author), Stronks, K. (author), Wennink, J.M.B. (author), Wolf, B.H.M. (author), Mahdi, U. (author), Nagelkerke, A.F. (author), van der Veer, E.M.A. (author), Westra, M. (author)

Background. Doctors and patients hold varying beliefs concerning illness and treatment. Patients' and families' explanatory models (EMs) vary according to personality and sociocultural factors. In a multi-ethnic society, it is becoming increasingly significant that doctors understand the different beliefs of their patients in order to improve...

article 2008

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The diagnostic work up of growth failure in secondary health care ; An evaluation of consensus guidelines

TNO Kwaliteit van Leven (author), Grote, F.K. (author), Oostdijk, W. (author), de Muinck Keizer-Schrama, S.M.P.F. (author), van Dommelen, P. (author), van Buuren, S. (author), Dekker, F.W. (author), Ketel, A.G. (author), Moll, H.A. (author), Wit, J.M. (author)

Background: As abnormal growth might be the first manifestation of undetected diseases, it is important to have accurate referral criteria and a proper diagnostic work-up. In the present paper we evaluate the diagnostic work-up in secondary health care according to existing consensus guidelines and study the frequency of underlying medical...

article 2008

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The art and practice of systems biology in medicine: Mapping patterns of relationships

van der Greef, J. (author), Martin, S. (author), Juhasz, P. (author), Adourian, A. (author), Plasterer, T. (author), Verheij, E.R. (author), McBurney, R.N. (author), TNO Kwaliteit van Leven (author)

Systems biology has developed in recent years from a technology-driven enterprise to a new strategic tool in Life Sciences, particularly for innovative drug discovery and drug development. Combining the ultimate in systems phenotyping with in-depth investigations of biomolecular mechanisms will enable a revolution in our understanding of disease...

article 2007

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Beyond counting cases: Public health impacts of national Paediatric Surveillance Units

Grenier, D. (author), Elliott, E.J. (author), Zurynski, Y. (author), Rodrigues Pereira, R. (author), Preece, M. (author), Lynn, R. (author), von Kries, R. (author), Zimmermann, H. (author), Dickson, N.P. (author), Virella, D. (author), TNO Kwaliteit van Leven (author)

Paediatric Surveillance Units (PSUs) have been established in 14 countries and facilitate national, prospective, active surveillance for a range of conditions, with monthly reporting by child health specialists. The International Network of Paediatric Surveillance Units (INoPSU) was established in 1998 and facilitates international collaboration...

article 2007

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Referral patterns of children with poor growth in primary health care

TNO Kwaliteit van Leven (author), Grote, F.K. (author), Oostdijk, W. (author), de Muinck Keizer-Schrama, S.M.P.F. (author), Dekker, F.W. (author), van Dommelen, P. (author), van Buuren, S. (author), Lodder-van der Kooij, A.M. (author), Verkerk, P.H. (author), Wit, J.M. (author)

Background. To promote early diagnosis and treatment of short stature, consensus meetings were held in the mid nineteen nineties in the Netherlands and the UK. This resulted in guidelines for referral. In this study we evaluate the referral pattern of short stature in primary health care using these guidelines, comparing it with cut-off values...

article 2007

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Sustainability of the prevention of passive infant smoking within well-baby clinics

Crone, M.R. (author), Verlaan, M. (author), Willemsen, M.C. (author), van Soelen, P. (author), Reijneveld, S.A. (author), Sing, R.A.H. (author), Paulussen, T.G.W.M. (author), TNO Kwaliteit van Leven (author)

This study assessed the antecedents of continued use of an education program to prevent passive smoking in infants. It consists of a booklet for parents and a manual for health professionals describing a five-step procedure for discussing passive smoking. Aquestionnairewas sent to 67 managers, 670 nurses, and 335 physiciansworking in well-baby...

article 2006

document

Putting pharmacogenetics into practice

Hopkins, M.M. (author), Ibarreta, D. (author), Gaisser, S. (author), Enzing, C.M. (author), Ryan, J. (author), Martin, P.A. (author), Lewis, G. (author), Detmar, S. (author), van den Akker-van Marle, M.E. (author), Hedgecoe, A.M. (author), Nightingale, P. (author), Dreiling, M. (author), Hartig, K.J. (author), Vullings, W. (author), Forde, T. (author)

article 2006

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Cost-effectiveness of pharmacogenomics in clinical practice: A case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe

van den Akker-van Marle, M.E. (author), Gurwitz, D. (author), Detmar, S.B. (author), Enzing, C.M. (author), Hopkins, M.M. (author), Gutierrez De Mesa, E. (author), Ibarreta, D. (author), TNO Kwaliteit van Leven (author)

Only a few studies have addressed the cost-effectiveness of pharmacogenetics interventions in healthcare. Lack of health economics data on aspects of pharmacogenetics is perceived as one of the barriers hindering its implementation for improving drug safety. Thus, a recent Institute for Prospective Technological Studies (IPTS) study, entitled ...

article 2006

document

Dermal absorption of chlorpyrifos in human volunteers

Meuling, W.J. (author), Ravensberg, L.C. (author), Roza, L. (author), van Hemmen, J.J. (author), TNO Kwaliteit van Leven (author)

Objective: The methods and results are described of a study on the dermal absorption of chlorpyrifos (CPF) in humans established via urinary excretion of the metabolite 3,5,6-trichloro-2-pyridinol (TCP). Methods: Two dermal, single, doses of CPF were applied in two study groups (A and B) each comprising three apparently healthy male volunteers...

article 2005