Searched for: subject%3A%22Clinical%255C%2Bobservation%22
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document
Bosgra, S. (author), Westerhout, J. (author)
In the EU collaborative project ChemScreen an alternative, in vitro assay-based test strategy was developed to screen compounds for reproductive toxicity. A toxicokinetic modeling approach was used to allow quantitative comparison between effective concentrations in the in vitro test battery and observations of developmental toxicity in vivo....
article 2015
document
van Mierlo, G.J.D. (author), Cnubben, N.H.P. (author), Wouters, D. (author), Wolbink, G.J. (author), Hart, M.H.L. (author), Rispens, T. (author), Ganderup, N.C. (author), Kuper, C.F. (author), Aarden, L. (author), Penninks, A.H. (author)
Immunogenicity is a major issue of concern for monoclonal antibodies used in human diseases and is by default mainly determined in non-human primates (NHP), as target molecules are considered most similar in NHP compared to human. In this manuscript the predictive value of immunogenicity testing in minipigs for human safety is evaluated, as the...
article 2014
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Hulst, J. (author), Joosten, K. (author), Zimmermann, L. (author), Hop, W. (author), van Buuren, S. (author), Büller, H. (author), Tibboel, D. (author), van Goudoever, J. (author), TNO Preventie en Gezondheid (author)
Background & Aims: Little is known about the nutritional status of critically ill children during hospitalisation in and after discharge from an intensive care unit. We set up a prospective, observational study to evaluate the nutritional status of children in an intensive care unit from admission up to 6 months after discharge. A secondary aim...
article 2004
document
Jonker, D. (author), Kuper, C.F. (author), Fraile, N. (author), Estrella, A. (author), Rodríguez Otero, C. (author), TNO Voeding (author)
Lycopene, as a suspension in sunflower oil (20% w/w), was tested for subchronic toxicity by administration at dietary concentrations of 0, 0.25, 0.50, and 1.0% to groups of 20 male and 20 female Wistar rats for a period of 90 days. The lycopene examined in this study was derived from a fungal biomass (Blakeslea trispora). Lycopene intake was...
article 2003
document
Hopman-Rock, M. (author), Tak, E.C.P.M. (author), Staats, P.G.M. (author)
Objective: Development and validation of a short Observation List of possible early signs of Dementia (OLD) for use in general practice. Design: Stepwise development using reviews of publications and expert consensus. Field study for evaluation of reliability. Validation study (interviews, family forms) using existing valid and reliable measures...
article 2001
Searched for: subject%3A%22Clinical%255C%2Bobservation%22
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