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van Kraaij, A.W.J. (author), Schiavone, G. (author), Lutin, E. (author), Claes, S. (author), van Hoof, C. (author)BACKGROUND: Chronic stress is increasing in prevalence and is associated with several physical and mental disorders. Although it is proven that acute stress changes physiology, much less is known about the relationship between physiology and long-term stress. Continuous measurement of vital signs in daily life and chronic stress detection...article 2020
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Oosterman, J.E. (author), Wopereis, S. (author), Kalsbeek, A. (author)Obesity and type 2 diabetes (T2D) have become a global health concern. The prevalence of obesity and T2D is significantly higher in shift workers compared to people working regular hours. An accepted hypothesis is that the increased risk for metabolic health problems arises from aberrantly timed eating behavior, that is, eating out of synchrony...article 2020
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van de Ven, H.A. (author), van der Klink, J.J.L. (author), Vetter, C. (author), Roenneberg, T. (author), Gordijn, M. (author), Koolhaas, W. (author), de Looze, M.P. (author), Brouwer, S. (author), Bültmann, U. (author)This study examined associations of chronotype and age with shift-specific assessments of main sleep duration, sleep quality and need for recovery in a cross-sectional study among N = 261 industrial shift workers (96.6% male). Logistic regression analyses were used, adjusted for gender, lifestyle, health, nap behaviour, season of assessment and...article 2016
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Koppes, L.J.J. (author), Geuskens, G.A. (author), Pronk, A. (author), Vermeulen, R.C.H. (author), de Vroome, E.M.M. (author)Experimental studies in animals indicate that disruption of the circadian rhythm is carcinogenic, and night work has been suggested to be a probable breast cancer cause in humans. Findings among humans, however are inconsistent, often gathered with retrospective study designs, and only based on specific populations, such as nurses. We used data...article 2014
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Simons, M. (author), TNO Defensie en Veiligheid (author)Het werken in de gezondheidszorg wordt gekenmerkt door wisselende werkschema’s, nachtdiensten en beschikbaarheiddiensten. De biologische klok van de mens kan zich daar niet voldoende aan aanpassen. Daardoor kunnen deze diensten leiden tot slaapgebrek en kan men tijdens de nachtdienst vermoeid en minder alert zijn. In industriële bedrijfstakken...article 2009
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Simons, M. (author), Valk, P.J.L. (author)This primary objective of this paper is to discuss the usefulness of melatonin for reducing symptoms of circadian rhythm disturbances in aircrew. Literature and own data of circadian disruptions and symptoms of aircrew were analysed. Considerations concerning the use of melatonin by aircrew are discussed. The main outcomes were as follows....article 2009
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van Loon, M. (author), Vautard, R. (author), Schaap, M. (author), Bergström, R. (author), Bessagnet, B. (author), Brandt, J. (author), Builtjes, P.J.H. (author), Christensen, J.H. (author), Cuvelier, C. (author), Graff, A. (author), Jonson, J.E. (author), Krol, M. (author), Langner, J. (author), Roberts, P. (author), Rouil, L. (author), Stern, R. (author), Tarrasón, L. (author), Thunis, P. (author), Vignati, E. (author), White, L. (author), Wind, P. (author), TNO Bouw en Ondergrond (author)Long-term ozone simulations from seven regional air quality models, the Unified EMEP model, LOTOS-EUROS, CHIMERE, RCG, MATCH, DEHM and TM5, are intercompared and compared to ozone measurements within the framework of the EuroDelta experiment, designed to assess air quality improvement at the European scale in response to emission reduction...article 2007
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Dekkers, S. (author), Telman, J. (author), Rennen, M.A.J. (author), Appel, M.J. (author), de Heer, C. (author), TNO Industrie en Techniek TNO Kwaliteit van Leven (author)In this study, the within-animal variation in routinely studied continuous toxicological parameters was estimated from temporal fluctuations in individual healthy nonexposed animals. Assuming that these fluctuations are nonadverse, this within-animal variation may be indicative of the minimal magnitude of the critical effect size (CES). The CES...article 2006
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van Leerdam, F.J.M. (author), Blankespoor, M.N. (author), van der Heijden, A.J. (author), Hiraing, R.A. (author), TNO Preventie en Gezondheid (author)Objective: To assess the effect of alarm treatment in children with day- and night-time wetting compared to those with night-time wetting only. Material and Methods: A total of 37 consecutive children (25 boys, 12 girls), all of whom suffered from both day- and night-time wetting, were compared to a group of 21 boys and 16 girls with nocturnal...article 2004
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Miedema, H.M.E. (author), Vos, H. (author), Instituut voor Ruimtelijke Organisatie TNO (author)This article integrates findings from the literature and new results regarding noise sensitivity. The new results are based on analyses of 28 combined datasets (N=23 038), and separate analyses of a large aircraft noise study (N=10939). Three topics regarding noise sensitivity are discussed, namely, its relationship with noise exposure, its...article 2003
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Bos, S.C. (author), Waterhouse, J. (author), Edwards, B. (author), Simons, R. (author), Reilly, T. (author), TNO Technische Menskunde (author)The endogenous circadian oscillator (the body clock) is slow to adjust to altered rest-activity patterns. As a result, several negative consequences arise during night work and after time-zone transitions. The process of adjustment can be assessed by measurements of the sleep electroencephalogram (EEG), core temperature or melatonin secretion,...article 2003
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van Someren, E.J.W. (author), Raymann, R.J.E.M. (author), Scherder, E.J.A. (author), Daanen, H.A.M. (author), Swaab, D.F. (author), TNO Technische Menskunde (author)At older ages, the circadian rhythm of body temperature shows a decreased amplitude, an advanced phase, and decreased stability. The present review evaluates to what extent these changes may result from age-related deficiencies at several levels of the thermoregulatory system, including thermoreception, thermogenesis and conservation, heat loss,...article 2002
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Castiglioni, P. (author), Parati, G. (author), Omboni, S. (author), Mancia, G. (author), Imholz, B.P.M. (author), Wesseling, K.H. (author), di Rienzo, M. (author), TNO Biomedical Instrumentation (author)The present study compares the spectral characteristics of 24-h blood pressure variability estimated invasively at the brachial artery level with those estimated by measurement of blood pressure at the finger artery using the non-invasive Portapres device. Broad-band spectra (from 3 x 10<sup>-5</sup> to 0.5 Hz) were derived from both finger and...article 1999
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Pasman, W.J. (author), Muls, G. (author), Vansant, G. (author), Westerterp-Plantenga, M.S. (author), Saris, W.H.M. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)OBJECTIVE: To investigate the effect of exercise training and dietary macronutrient composition on 24 h substrate oxidation in male, obese subjects. DESIGN: A 16 month exercise intervention study was executed, including a weight loss period with a very low energy diet (VLED) for 2 months at the start of the study. SUBJECTS: Twelve male, obese...article 1999
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Bank, R.A. (author), Beekman, B. (author), Verzijl, N. (author), de Roos, J.A.D.M. (author), Nico Sakkee, A. (author), Tekoppele, J.M. (author), TNO Preventie en Gezondheid (author)A high-performance liquid chromatographic assay was developed for pyridinium crosslinks and pentosidine in mature collagen of a wide variety of connective tissue hydrolysates by a simple two-step isocratic assay using a reversed-phase column. The crosslinks (including the internal standard pyridoxine) were optimally detected by their native...article 1997
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Andreotti, F. (author), Prevost, R. (author), Lupi, A. (author), Hamilton, J. (author), de Bart, A.C.W. (author), Huisman, L.G.M. (author), Maseri, A. (author), Kluft, C. (author), Gaubius Instituut TNO (author)Raised plasma PAI-1 and t-PA antigen levels are known risk factors for acute coronary events. It is not known whether these factors are related to coronary thrombosis or to a possible atherosclerotic background. Both factors show a marked circadian variation in blood. To assess the effect of atherosclerosis on the fibrinolytic balance, we...article 1996
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Theeuwes, J. (author), Riemersma, J.B.J. (author), TNO Technische Menskunde (author)In Sweden the use of daytime running lights (DRL) was made mandatory on 1 October 1977 for all motor vehicles at once, during all seasons and for all areas. According to a study conducted by Andersson and Nilsson (1981) the introduction of DRL resulted in a reduction of 11% of multiple accidents during daytime. In many discussions on the...article 1995
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Odink, J. (author), Kramer, F.M. (author), van der Beek, E.J. (author), Thissen, J.T.N.M. (author), Kempen, H.J.M. (author), van den Berg, H. (author), Egger, R.J. (author), Wientjes, C.J.E. (author), CIVO-TNO Nederlands instituut voor praeventieve gezondheidszorg TNO, NIPG-TNO Gaubius instituut TNO, GI-TNO Instituut voor zintuigfysiologie TNO, IZF-TNO (author)This study was designed to investigate the relation between fatty acid consumption, total plama cholesterol and neuroendocrine response to exposure to stress, factors thought to play a role in the development of coronary heart disease. For this purpose 32 apparently healthy male volunteers were classified on the basis of their plasma cholesterol...article 1989
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de Groot, A.P. (author), Feron, V.J. (author), Immel, H.R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In previous studies we observed an increased incidence of hyperplasia in the epithelium of the urinary bladder of rats fed cereal-based stock diet supplemented with 6% monosodium glutamate (MSG) for 3 months. Hyperplasia was not enhanced, however, when 6% MSG was fed in a purified casein diet. Further studies have been conducted to identify the...article 1988
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Speek, A.J. (author), Thissen, J.T.N.M. (author), Schrijver, J. (author), Instituut CIVO-Toxicologie en voeding TNO (author)The urinary excretion of 3-methylhistidine and creatinine and the urinary 3-methylhistidine to creatinine excretion ratio during day and night were investigated in a group of 103 healthy, normally fed Dutch children (52 boys and 51 girls) aged 2-17 years. The 3-methylhistidine to creatinine ratio of the night urine appeared to be significantly...article 1986