Searched for: subject%3A%22Chronic%255C%2Bdisease%22
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Detmar, S.B. (author), Bruil, J. (author), Ravens-Sieberer, U. (author), Gosch, A. (author), Bisegger, C. (author), TNO Kwaliteit van Leven (author)
There is increasing interest in the public health sector in the health-related quality of life (HRQL) of healthy children. However, most HRQL instruments are developed for children with a chronic illness. In addition, existing questionnaires are mostly based on expert opinion about what constitutes HRQL and the opinions and views of healthy...
article 2006
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Hartgers, F.C. (author), Smits, H.H. (author), van der Kleij, D. (author), Yazdanbakhsh, M. (author), TNO Defensie en Veiligheid (author)
Helminth infections have profound effects on the immune system. Here, recent insights in the molecular interactions between schistosomes and the host are described with respect to adaptive but also with respect to innate immune responses. Furthermore, the different mechanisms of immune hyporesponsiveness are depicted with emphasis on regulatory...
article 2006
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Detmar, S.B. (author), Hosli, E.J. (author), Chorus, A.M.J. (author), van Beekum, T. (author), Vogels, T. (author), Mourad-Baars, P.E.C. (author), Engelberts, A.C. (author), Groothuis - Oudshoorn, C.G.M. (author), Verrips, G.H.W. (author)
Introduction: This paper describes the development and initial psychometric evaluation of the Handicap Scale for Children (HSC). This questionnaire is based on the London Handicap Scale (LHS), a valid and reliable utility instrument for measuring social participation in adults. Methods: A multidisciplinary research group was involved in...
article 2005
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Perenboom, R.J.M. (author), van Herten, L.M. (author), Boshuizen, H.C. (author), van den Bos, G.A.M. (author)
Objective. Life expectancy without chronic morbidity, or morbidity-free life expectancy (MFLE), was calculated to measure changes in population health status between 1989 and 2000 on the basis of gender and socioeconomic status. Methods. Sullivan's method was used to calculate morbidity-free life expectancy. Prevalence rates for chronic...
article 2005
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Staal, J.B. (author), Rainville, J. (author), Fritz, J. (author), van Mechelen, W. (author), Pransky, G. (author), TNO Kwaliteit van Leven (author)
Introduction: There is a body of literature that indicates that physical exercise interventions, with a primary focus on improvement of functioning instead of pain relief, might be effective to stimulate return to work and improve function in workers who are absent from work due to low back pain (LBP). Successful application and implementation...
article 2005
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TNO Kwaliteit van Leven (author), Bruil, J. (author), Detmar, S.B. (author)
article 2005
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Andries, F. (author), Kremer, A.M. (author), Hoogendoorn, W.E. (author), Wevers, C.W.J. (author), van Putten, D.J. (author)
The Work and Handicap Questionnaire (WHQ) was developed to improve the vocational perspectives of patients with a chronic disorder. The WHQ differs from similar instruments in its explicit linkage between disabilities in daily life and job demands. This is an important feature, which allows for the development of specific strategies to counter...
article 2004
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'T Hart, B.A. (author), Vogels, J. (author), Bauer, J. (author), Brok, H.P.M. (author), Blezer, E. (author), TNO Voeding (author)
Early recognition of whether a product has potential as a new therapy for treating multiple sclerosis (MS) relies upon the quality of the animal models used in the preclinical trials. The promising effects of new treatments in rodent models of experimental autoimmune encephalomyelitis (EAE) have rarely been reproduced in patients suffering from...
article 2004
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Koopman, H.M. (author), Bruil, J. (author), Detmar, S.B. (author), Baars, R.M. (author), Wit, J.M. (author)
With the help of seven questions: What is health related quality of life (HRQoL)? How can HRQoL be measured? What conditions do HRQoL instruments need to meet? For what purpose can HRQoL instruments be used? Who completes the questionnaires? In what way can paediatricians use the HRQoL results? What does HRQoL research look like in future? an...
article 2003
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O'Connor, D.H. (author), Mothe, B.R. (author), Weinfurter, J.T. (author), Fuenger, S. (author), Rehrauer, W.M. (author), Jing, P. (author), Rudersdorf, R.R. (author), Liebl, M.E. (author), Krebs, K. (author), Vasquez, J. (author), Dodds, E. (author), Loffredo, J. (author), Martin, S. (author), McDermott, A.B. (author), Allen, T.M. (author), Wang, C. (author), Doxiadis, G.G. (author), Montefiori, D.C. (author), Hughes, A. (author), Burton, D.R. (author), Allison, D.B. (author), Wolinsky, S.M. (author), Bontrop, R. (author), Picker, L.J. (author), Watkins, D.I. (author)
Certain major histocompatibility complex class I (MHC-I) alleles are associated with delayed disease progression in individuals infected with human immunodeficiency virus (HIV) and in macaques infected with simian immunodeficiency virus (SIV). However, little is known about the influence of these MHC alleles on acute-phase cellular immune...
article 2003
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TNO Preventie en Gezondheid (author), Robine, J.M. (author), Jagger, C. (author), Egidi, V. (author), Gispert, R. (author), Nusselder, W. (author), Perenboom, R. (author), Rasmussen, N. (author), Ritchie, K. (author), van den Berg, J. (author), van Oyen, H. (author)
The Euro-REVES 2 project, 'Setting up of a coherent set of health expectancies for the European Union', was begun in 1998 under the European Health Monitoring Programme with the aim of selecting a concise set of instruments to simultaneously monitor mortality and the different facets of health. An in-depth analysis of the current health survey...
article 2003
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TNO Preventie en Gezondheid (author), Bayley, J.P. (author), Bakker, A.M. (author), Kaijzel, E.L. (author), Huizinga, T.W.J. (author), Verweij, C.L. (author)
Objective. To assess the role of polymorphisms of the tumour necrosis factor (TNF) receptors, TNF-RI (p55) and TNF-RII (p75) in the susceptibility to and severity of rheumatoid arthritis (RA) in Dutch patients. Methods. A total of 319 consecutive RA patients, and a cohort of 90 female RA patients with detailed 12-yr follow-up were genotyped for...
article 2003
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Feron, V.J. (author), Kittel, B. (author), Kuper, C.F. (author), Ernst, H. (author), Rittinghausen, S. (author), Muhle, H. (author), Koch, W. (author), Gamer, A. (author), Mallett, A.K. (author), Hoffmann, H.D. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Two independent bioassays are available which have examined the potential carcinogenicity of monomeric and polymeric methylene diphenyl diisocyanate (MDI) following long-term inhalation exposure in rats. These studies are not directly comparable, however, due to differences in design and conduct of the in-life phase, and differences in...
article 2001
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Segers, P. (author), Stergiopulos, N. (author), Schreuder, J.J. (author), Westerhof, B.E. (author), Westerhof, N. (author)
It is generally accepted that the left ventricle (LV) hypertrophies (LVH) to normalize systolic wall stress (σ(s)) in chronic pressure overload. However, LV filling pressure (P(v)) may be elevated as well, supporting the alternative hypothesis of end-diastolic wall stress (σ(d)) normalization in LVH. We used an LV time-varying elastance model...
article 2000
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Hildebrandt, V.H. (author), Proper, K.I. (author), van den Berg, R. (author), Douwes, M. (author), van den Heuvel, S.G. (author), van Buuren, S. (author), TNO Preventie en Gezondheid (author)
Objective. To determine the effectiveness of a special form of exercise therapy ('Cesar therapy') on self reported recovery and improvement of posture amongst patients with chronic aspecific lower back pain. Design. Prospective randomized controlled and blinded investigation. Method. After informed consent had been obtained, patients with...
article 2000
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Sprangers, M.A.G. (author), de Regt, E.B. (author), Andries, F. (author), van Agt, H.M.E. (author), Bijl, R.V. (author), de Boer, J.B. (author), Foets, M. (author), Hoeymans, N. (author), Jacobs, A.E. (author), Kempen, G.I.J.M. (author), Miedema, H.S. (author), Tijhuis, M.A.R. (author), de Haes, H.C.J.M. (author), NIA TNO (author)
The objective of the present study is to compare the QL of a wide range of chronic disease patients. Secondary analysis of eight existing data sets, including over 15,000 patients, was performed. The studies were conducted between 1993 and 1996 and included population-based samples, referred samples, consecutive samples, and/or consecutive...
article 2000
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Verrips, G.H.W. (author), Vogels, A.G.C. (author), den Ouden, A.L. (author), Paneth, N. (author), Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author)
The aim of this study was to evaluate the agreement between children and proxies as well as the agreement between methods of administration in assessing Health-Related Quality of Life (HRQoL) using the TNO AZL Children's Quality Of Life (TACQOL) questionnaire. A random sample from a Dutch cohort of 14-year-old very low birth weight children and...
article 2000
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Verrips, E.G.H. (author), Vogels, T.G.C. (author), Koopman, H.M. (author), Theunissen, N.C.M. (author), Kamphuis, R.P. (author), Fekkes, M. (author), Wit, J.M. (author), Verloove-Vanhorick, S.P. (author)
Background: The 56-item TNO AZL Child Quality Of Life (TACQOL) questionnaire was developed to meet the need for a reliable and valid instrument for measuring health-related quality of life (HRQoL) in children. HRQoL was defined as health status in seven domains plus emotional responses to problems in health status. The TACQOL explicitly offers...
article 1999
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Gaubius instituut TNO (author), Bank, R.A. (author), Tekoppele, J.M. (author), Oostingh, G. (author), Hazleman, B.L. (author), Riley, G.P. (author)
Objectives - To investigate age related and site specific variations in turnover and chemistry of the collagen network in healthy tendons as well as the role of collagen remodelling in the degeneration of the supraspinatus tendon (ST-D) in rotator cuff tendinitis. Methods - Collagen content and the amount of hydroxylysine (Hyl),...
article 1999
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Hopman-Rock, M. (author), Kraaimaat, F.W. (author), Odding, E. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)
Objective. To investigate the use of pain coping strategies by community-living older people with pain in the hip or knee and the mediating role of coping with pain in the relationship between the chronicity of pain and physical disability. Methods. A group of 157 people with pain 'in the last month' was identified. Coping with pain was assessed...
article 1998
Searched for: subject%3A%22Chronic%255C%2Bdisease%22
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