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Luijten, M. (author), Olthof, E.D. (author), Hakkert, B.C. (author), Rorije, E. (author), van der Laan, J.-W. (author), Woutersen, R.A. (author), van Benthem, J. (author)Assessment of genotoxic and carcinogenic potential is considered one of the basic requirements when evaluating possible human health risks associated with exposure to chemicals. Test strategies currently in place focus primarily on identifying genotoxic potential due to the strong association between the accumulation of genetic damage and cancer...article 2016
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Garthoff, J.A. (author), Heemskerk, S. (author), Hempenius, R.A. (author), Lina, B.A.R. (author), Krul, C.A.M. (author), Koeman, J.H. (author), Speijers, G.J.A. (author), TNO Kwaliteit van Leven (author)Pectin-derived acidic oligosaccharides (pAOS) are non-digestible carbohydrates to be used in infant formulae and medical nutrition. To support its safety, the genotoxic potential of pAOS was evaluated. pAOS was not mutagenic in the Ames test. Positive results were obtained in the chromosome aberration test only at highly cytotoxic concentrations...article 2010
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Ponstein-Simarro Doorten, A.Y. (author), van de Wiel, J.A.G. (author), Jonker, D. (author), TNO Kwaliteit van Leven (author)Tensguard™ is a milk protein hydrolysate containing the lactotripeptide IPP. It is derived from cow's milk, which is present in the human diet and has a safe history of consumption. The final Tensguard™ product, a supplement or a functional food ingredient, is intended for use by people who want to follow a healthy diet and lifestyle in order to...article 2009
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Weijenberg, M.P. (author), Lüchtenborg, M. (author), de Goeij, A.F.P.M. (author), Brink, M. (author), van Muijen, G.N.P. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Objective: To investigate baseline fat intake and the risk of colon and rectal tumors lacking MLH1 (mutL homolog 1, colon cancer, nonpolyposis type 2) repair gene expression and harboring mutations in the APC (adenomatous polyposis coli) tumor suppressor gene and in the KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) oncogene....article 2007
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Liebsch, M. (author), Spielmann, H. (author), Pape, W. (author), Krul, C. (author), Deguercy, A. (author), Eskes, C.A.M. (author), TNO Kwaliteit van Leven (author)Regulatory requirements: According to the current Notes for Guidance of the Scientific Committee on Cosmetic Products and Non-Food Products (SCCNFP), cosmetic ingredients and mixtures of ingredients absorbing UV light (in particular UV filter chemicals used, for example, to ensure the light stability of cosmetics or used in sun protection...article 2005
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- Maurici, D. (author), Aardema, M. (author), Corvi, R. (author), Kleber, M. (author), Krul, C.A.M. (author), Laurent, C. (author), Loprieno, N. (author), Pasanen, M. (author), Pfuhler, S. (author), Phillips, B. (author), Sabbioni, E. (author), Sanner, T. (author), Vanparys, P. (author), TNO Kwaliteit van Leven TNO Voeding (author) article 2005
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Bär, A. (author), Krul, C.A.M. (author), Jonker, D. (author), de Vogel, N. (author), TNO Voeding (author)Alpha-cyclodextrin glucosyltransferase (α-CGTase, EC 2.4.1.19) is an amylolytic enzyme used for the production of α-cyclodextrin (α-CD), a novel, soluble dietary fiber, from food-grade starch. The safety of an α-CGTase preparation obtained by batch fermentation from a recombinant strain of Escherichia coli K12 harboring the α-CGTase gene from...article 2004
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Roza, L. (author), de Vogel, N. (author), van Delft, J.H.M. (author)Hydroquinone (HQ) occurs in the environment as a result of manmade processes as well as in natural products from plants and animals. The compound has been reported to produce chromosomal effects in some in vivo and in vitro animal models. However, its potential to produce similar effects in human lymphocytes is less clear. To obtain more...article 2003
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Anderson, D. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO BIBRA (author)Butadiene (BD) and its 2-methyl analogue, isoprene, have been extensively studied in animals and BD in population studies. Both chemicals are metabolised by liver cytochrome P450 dependent monogenases to monoepoxide and diepoxide intermediates. The diepoxide intermediates of both compounds were mutagenic in Salmonella typhimurium. However,...article 2001
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Asosingh, K. (author), Radl, J. (author), van Riet, I. (author), van Camp, B. (author), van der Kerken, K. (author), TNO Preventie en Gezondheid (author)Chemicals/CAS: Cancer Vaccines; Myeloma Proteins; pristane, 1921-70-6; Terpenes; Vaccines, DNAarticle 2000
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Albertini, R.J. (author), Anderson, D. (author), Douglas, G.R. (author), Hagmar, L. (author), Hemminki, K. (author), Merlo, F. (author), Natarajan, A.T. (author), Norppa, H. (author), Shuker, D.E.G. (author), Tice, R. (author), Waters, M.D. (author), Aitio, A. (author), TNO Kwaliteit van Leven TNO Bibra (author)The purpose of these guidelines is to provide concise guidance on the planning, performing and interpretation of studies to monitor groups or individuals exposed to genotoxic agents. Most human carcinogens are genotoxic but not all genotoxic agents have been shown to be carcinogenic in humans. Although the main interest in these studies is due...article 2000
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Edwards, A.J. (author), Price, R.J. (author), Renwick, A.B. (author), Lake, B.G. (author), TNO BIBRA TNO Kwaliteit van Leven (author)The ability of coumarin to induce UDS in male Sprague-Dawley CD rat hepatocytes in vivo was assessed using the unscheduled DNA synthesis (UDS) assay. From a preliminary toxicity study the oral maximum tolerated dose (MTD) of coumarin was determined to be 320mg/kg body weight. For the UDS studies, rats were treated with 0 (corn oil control), 32 ...article 2000
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Emri, G. (author), Wenczl, E. (author), van Erp, P. (author), Jans, J. (author), Roza, L. (author), Horkay, I. (author), Schothorst, A.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Chromosomal defects are frequently present in malignant and premalignant skin disorders; however, it is not known whether ultraviolet radiation from sunlight plays a role in their induction. To obtain information on the ability of ultraviolet A and ultraviolet B to induce chromosomal aberrations, cultured melanocytes and fibroblasts were exposed...article 2000
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Anderson, D. (author), Phillips, B.J. (author), Yu, T-W. (author), Edwards, A.J. (author), Ayesh, R. (author), Butterworth, K.R. (author)Twenty-four men and 24 women, all nonsmoking, and maintaining normal dietary habits were assigned to 3 groups of 16. Each group comprising 4 males with "low" cholesterol levels (<6 mmol/L) matched for age and build with 4 males with "high" cholesterol levels (>6 mmol/L) and 8 similarly matched females. A three-treatment, three-treatment period,...article 2000
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Turnbull, D. (author), Frankos, V.H. (author), van Delft, J.H.M. (author), de Vogel, N. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Plant stanol esters from wood and vegetable oil sources were tested for genotoxicity in bacterial (Salmonella typhimurium) and mammalian cell (L5178Y) gene mutation assays and in a mammalian cell chromosome aberration assay (CHO cells). The two stanol ester formulations were tested separately at doses up to the limit of solubility, with and...article 1999
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van Delft, J.H.M. (author), Baan, R.A. (author), Roza, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In this review data are summarized on biomarkers that are used for biological effect monitoring of human populations exposed to genotoxic carcinogens. The biomarkers are DNA and protein adducts and cytogenetic effects. Most of these biomarkers are relevant for the process of carcinogenesis. Emphasis is on providing information on the properties...article 1998
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Rompelberg, C.J.M. (author), Vogels, J.T.W.E. (author), de Vogel, N. (author), Bruijntjes-Rozier, G.C.D.M. (author), Stenhuis, W.H. (author), Bogaards, J.J.P. (author), Verhagen, H. (author), TNO Voeding (author)1. In order to study the antigenotoxic potential of eugenol in humans, ten healthy non-smoking males ingested a daily amount of 150 mg eugenol or the placebo for seven consecutive days. After a washout period of one week, groups ingesting eugenol or the placebo were crossed and received the other treatment for seven consecutive days. 2. On days...article 1996
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van den Akker, Th.W. (author), Radl, J. (author), Franken-Postma, E. (author), Hagemeijer, A. (author), Gaubius Instituut TNO (author)Multiple myeloma (MM) and Waldenström's macroglobulinemia-like lymphoma (MW) appear spontaneously in C57BL/KaLwRij mice at a frequency of 0.5% and 0.2%, respectively. They can readily be propagated by intravenous transfer of mainly bone marrow or spleen cells into syngeneic recipients. Previous studies demonstrated that these mouse malignant...article 1996
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Vink, G.J. (author), Davis, P.B. (author), Hooftman, R.N. (author), Mattern, I.E. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: aroclor, 12767-79-2; benzo[a]pyrene, 50-32-8; mesylic acid ethyl ester, 62-50-0; mesylic acid methyl ester, 66-27-3; triaziquone, 68-76-8article 1981