Searched for: subject:"Chromatography"
(1 - 20 of 351)

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Kelly, J.M. (author), Matuszek, G. (author), van den Broek, T.J. (author), Huggins, G.S. (author), Smith, C.E. (author), Ordovas, J.M. (author), Wopereis, S. (author), Booth, S.L. (author)
Inconsistent associations between lipids and circulating markers of fat-soluble vitamin and carotenoid status have been reported. The aim of this hypothesis-generating study was to examine the contribution of the LC-MS-based lipidome, characterized by lipid class, carbon count, and the number of unsaturated bonds, to the interindividual...
article 2020
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Bezemer, K. (author), McLennan, L. (author), van Duin, L. (author), Kuijpers, C.J. (author), Koeberg, M. (author), van den Elshout, J.J.M.H. (author), van der Heijden, A.E.D.M. (author), Busby, T. (author), Yevdokimov, A. (author), Schoenmakers, P. (author), Smith, J. (author), Oxley, J. (author), van Asten, A. (author)
Erythritol tetranitrate (ETN) was prepared independently by two research groups from the USA and the Netherlands. The partially nitrated impurities present in ETN were studied using liquid chromatography-mass spectrometry to address the ultimate challenge in forensic explosives investigations, i.e., providing chemical and tactical information on...
article 2020
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Bezemer, K. (author), McLennan, L. (author), Hessels, R. (author), Schoorl, J. (author), van den Elshout, J.J.M.H. (author), van der Heijden, A.E.D.M. (author), Hulsbergen, A. (author), Koeberg, M. (author), Busby, T. (author), Yevdokimov, A. (author), Rijke, E. (author), Schoenmakers, P. (author), Smith, J. (author), Oxley, J. (author), van Asten, A. (author)
In this follow-up study the collaboration between two research groups from the USA and the Netherlands was continued to expand the framework of chemical attribution for the homemade explosive erythritol tetranitrate (ETN). Isotope ratio mass spectrometry (IRMS) analysis was performed to predict possible links between ETN samples and its...
article 2020
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van der Schans, M.J. (author)
Chemical warfare agents (CWAs) are the most toxic compounds that have ever been produced. In order to develop medical countermeasures against the effects of these agents, analytical procedures to analyze these agents in their intact form in biological matrices are essential for a better understanding of the toxicological process. Although the...
bookPart 2020
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van den Dries, M.A. (author), Guxens, M. (author), Spaan, S. (author), Ferguson, K.K. (author), Philips, E. (author), Santos, S. (author), Jaddoe, V.W.V. (author), Ghassabian, A. (author), Trasande, L. (author), Tiemeier, H. (author), Pronk, A. (author)
BACKGROUND: Prenatal exposures to phthalates and bisphenols are associated with impaired brain development in animals. However, epidemiological studies investigating the association between prenatal phthalate or bisphenol exposure and cognition have produced mixed findings and mostly had modest sample sizes and measured the exposure during the...
article 2020
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Pérez-Gallent, E. (author), Figueiredo, M.C. (author), Koper, M.T.M. (author)
Efficient and selective electrosynthesis of propylene carbonate can be performed by the reaction of carbon dioxide with propylene oxide at copper electrodes. In this paper, we investigate this electrochemical reaction by using cyclic voltammetry, Fourier transform infrared spectroscopy and high-performance liquid chromatography in order to...
article 2019
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van Groen, B.D. (author), van de Steeg, E. (author), Mooij, M.G. (author), van Lipzig, M.M.H. (author), de Koning, B.A.E. (author), Verdijk, R.M. (author), Wortelboer, H.M. (author), Gaedigk, R. (author), Bi, C. (author), Leeder, S. (author), van Schaik, R.H.N. (author), van Rosmalen, J. (author), Tibboel, D. (author), Vaes, W.H. (author), de Wildt, S.N. (author)
Background Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age with absolute transporter protein expression in a cohort of 62 mainly fetus and newborn samples. Methods Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3,...
article 2018
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Carmany, D. (author), Walz, A.J. (author), Hsu, F.L. (author), Benton, B. (author), Burnett, D. (author), Gibbons, J. (author), Noort, D. (author), Glaros, T. (author), Sekowski, J.W. (author)
Organophosphorus (OP) nerve agents continue to be a threat at home and abroad during the war against terrorism. Human exposure to nerve agents such as VX results in a cascade of toxic effects relative to the exposure level including ocular miosis, excessive secretions, convulsions, seizures, and death. The primary mechanism behind these overt...
article 2017
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Fiamoncini, J. (author), Yiorkas, A.M. (author), Gedrich, K. (author), Rundle, M. (author), Alsters, S.I. (author), Roeselers, G. (author), van den Broek, T.J. (author), Clavel, T. (author), Lagkouvardos, I. (author), Wopereis, S. (author), Frost, G. (author), van Ommen, B. (author), Blakemore, A.I. (author), Daniel, H. (author)
Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women (n = 72, 62 ± 8 yr,...
article 2017
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Kasiotis, K.M. (author), Tsakirakis, A.N. (author), Richard Glass, C. (author), Charistou, A.N. (author), Anastassiadou, P. (author), Gerritsen-Ebben, R. (author), Machera, K. (author)
A dislodgeable foliar residue study was conducted in greenhouse pepper and tomato on the island of Crete, Greece, following the spray application of an SC insecticide (with active substance (a.s.) tebufenozide) and an EC fungicide (a.s. bupirimate). Furthermore, for the assessment of worker exposure to pesticides – as a result of re-entering the...
article 2017
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Schultze-Jena, A. (author), Boon, M.A. (author), Bussmann, P.J.T. (author), Janssen, A.E.M. (author), van der Padt, A. (author)
In industrial liquid separation processes chromatography often has a key function in the optimization of yield and purity. For the design of an industrial system, chromatographic processes are generally simulated using mathematical models, tested and optimized at laboratory level, and then scaled up to pilot and subsequently industrial scale. To...
article 2017
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den Uil, H. (author), Wittkampf, S.A. (author)
ECN has developed a simple and inexpensive method to prevent clogging of dust in capillary columns of mass spectrometers or gas chromatographs. In some processes there are dust particles present in the process gas. The method developed by ECN is a smart solution that helps to prevent that dust particles end up in the analyzer.
other 2016
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Bezemer, K.D.B. (author), Koeberg, M. (author), van der Heijden, A.E.D.M. (author), van Driel, C.A. (author), Blaga, C. (author), Bruinsma, J. (author), van Asten, A.C. (author)
Studying links between triacetone triperoxide (TATP) samples from crime scenes and suspects can assist in criminal investigations. Isotope ratio mass spectrometry (IRMS) and gas chromatography (GC)-IRMS were used to measure the isotopic compositions of TATP and its precursors acetone and hydrogen peroxide. In total, 31 TATP samples were...
article 2016
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Stroeve, J.H.M. (author), Saccenti, E. (author), Bouwman, J. (author), Dane, A. (author), Strassburg, K. (author), Vervoort, J. (author), Hankemeier, T. (author), Astrup, A. (author), Smilde, A.K. (author), van Ommen, B. (author), Saris, W.H.M. (author)
Objective: Aim is to predict successful weight loss by metabolic signatures at baseline and to identify which differences in metabolic status may underlie variations in weight loss success. Methods: In DiOGenes, a randomized, controlled trial, weight loss was induced using a low calorie diet (800 kcal) for 8-weeks. Men (N5236) and women (N5431)...
article 2016
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Cnubben, N.H.P. (author), Tel, S.L. (author), Hemmes, M.A. (author), Langenkamp-Brand, A. (author), Grossouw, D. (author), Jansen, H.T. (author), de Bie, B.T.H.J. (author)
Background: Worldwide obesity has nearly doubled since 1980 and is a leading risk for global deaths, profoundly affecting morbidity, mortality, health-care costs, and professional and personal quality of life. Treatment of obesity and its consequences include lifestyle intervention, pharmacotherapy, and bariatric surgery. Polyglucosamines have...
article 2016
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Koster, S. (author), Leeman, W.R. (author), Verheij, E.R. (author), Dutman, A.E. (author), van Stee, L.L.P. (author), Munch Nielsen, L. (author), Ronsmans, S. (author), Noteborn, H. (author), Krul, L. (author)
A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult...
article 2015
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Nohynek, G.J. (author), Skare, J.A. (author), Meuling, W.J.A. (author), Wehmeyer, K.R. (author), de Bie, A.T.H.J. (author), Vaes, W.H.J. (author), Dufour, E.K. (author), Fautz, R. (author), Steiling, W. (author), Bramante, M. (author), Toutain, H. (author)
Systemic exposure was measured in humans after hair dyeing with oxidative hair dyes containing 2.0% (A) or 1.0% (B) [14C]-p-phenylenediamine (PPD). Hair was dyed, rinsed, dried, clipped and shaved; blood and urine samples were collected for 48 hours after application. [14C] was measured in all materials, rinsing water, hair, plasma, urine and...
article 2015
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Majchrzykiewicz-Koehorst, J.A. (author), Heikens, E. (author), Trip, H. (author), Hulst, A.G. (author), de Jong, A.L. (author), Viveen, M.C. (author), Sedee, N.J.A. (author), van der Plas, J. (author), Coenjaerts, F.E.J. (author), Paauw, A. (author)
The rapid identification of existing and emerging respiratory viruses is crucial in combating outbreaks and epidemics. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid and reliable identification method in bacterial diagnostics, but has not been used in virological diagnostics. Mass...
article 2015
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Garner, C.R. (author), Park, K.B. (author), French, N.S. (author), Earnshaw, C. (author), Schipani, A. (author), Selby, A.M. (author), Byrne, L. (author), Siner, S. (author), Crawley, F.P. (author), Vaes, W.H.J. (author), van Duijn, E. (author), de ligt, R. (author), Varendi, H. (author), Lass, J. (author), Grynkiewicz, G. (author), Maruszak, W. (author), Turner, M.A. (author)
Aims The aims of the study were to compare [14C]-paracetamol ([14C]-PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose and to develop further and validate accelerator mass spectrometry (AMS) bioanalysis in the 0-2 year old age group. Methods [14C]-PARA concentrations in 10-15 μl...
article 2015
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Rodriguez-Illera, M. (author), Boon, M.A. (author), Boom, R.M. (author), Janssen, A.E.M. (author)
We present guidelines for the configuration of industrial scale chromatographic separationof small molecules. We compared the performance of different axial packed beds, chan-neled monoliths and a continuous monolith assuming silica as base material. The calculatedmass transfer rates were used to calculate the height of a theoretical plate (HETP...
article 2015
Searched for: subject:"Chromatography"
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