Searched for: subject%3A%22Cholesterol%255C%2Bblood%255C%2Blevel%22
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Riese, H. (author), Houtman, I.L.D. (author), Doornen, L.J.P. (author), de Geus, E.J.C. (author)
This study examined the possible effects of job demands, decision latitude, and job-related social support on risk indicators for cardiovascular disease (CVD) in 165 female nurses. Job strain was measured with the Job Content Questionnaire; CVD risk was measured with insulin, total cholesterol, triglyceride (TG), high-density lipoprotein...
article 2000
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TNO Preventie en Gezondheid (author), Sijbrands, E.J.G. (author), Westendorp, R.G.J. (author), Paola Lombardi, M. (author), Havekes, L.M. (author), Frants, R.R. (author), Kastelein, J.J.P. (author), Smelt, A.H.M. (author)
Life expectancy of patients with familial hypercholesterolaemia is decreased. Some untreated patients reach a normal life span and, therefore, additional risk factors and the type of mutation in the low-density lipoprotein (LDL) receptor gene are likely to influence the clinical outcome. We determined all cause mortality in kindreds with the...
article 2000
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Anderson, D. (author), Phillips, B.J. (author), Yu, T-W. (author), Edwards, A.J. (author), Ayesh, R. (author), Butterworth, K.R. (author)
Twenty-four men and 24 women, all nonsmoking, and maintaining normal dietary habits were assigned to 3 groups of 16. Each group comprising 4 males with "low" cholesterol levels (<6 mmol/L) matched for age and build with 4 males with "high" cholesterol levels (>6 mmol/L) and 8 similarly matched females. A three-treatment, three-treatment period,...
article 2000
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van de Vijver, L.P.L. (author), Kardinaal, A.F.M. (author), van Duyvenvoorde, W. (author), Kruijssen, D.A.C.M. (author), Grobbee, D.E. (author), van Poppel, G. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)
Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years of age. The ankle-arm index was calculated for...
article 1999
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Turnbull, D. (author), Whittaker, M.H. (author), Frankos, V.H. (author), Jonker, D. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Plant sterols and their saturated derivatives, known as stanols, reduce serum cholesterol when consumed in amounts of approximately 2 g per day. Stanol fatty acid esters have been developed as a highly fat-soluble form that may lower cholesterol more effectively than stanols. Stanol esters occur naturally in human diets, but at levels far below...
article 1999
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Hendriks, H.F.J. (author), Weststrate, J.A. (author), van Vliet, T. (author), Meijer, G.W. (author)
Objective: To investigate the dose-response relationship between cholesterol lowering and three different, relatively low intake levels of plant sterols (0.83, 1.61, 3.24 g/d) from spreads. To investigate the effects on lipid-soluble (pro)vitamins. Design: A randomized double-blind placebo controlled balanced incomplete Latin square design using...
article 1999
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Weggemans, R.M. (author), Zock, P.L. (author), Urgert, R. (author), Katan, M.B. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background. Hypercholesterolaemia is initially treated by diet. However, most studies of diet and cholesterol response have been carried out in men, and it is not known whether women react to diet to the same extent as men do. We therefore studied sex differences in the response of serum cholesterol and lipoproteins to diet. Materials and...
article 1999
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van de Vijver, L.P.L. (author), Weber, C. (author), Kardinaal, A.F.M. (author), Grobbee, D.E. (author), Princen, H.M.G. (author), van Poppel, G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Coenzyme Q10 (CoQ10) is an important mitochondrial electron transfer component and has been postulated to function as a powerful antioxidant protecting LDL from oxidative damage. It could thus reduce the risk of cardiovascular disease. Thus far, beneficial effects of supplementation with CoQ10 have been reported. To study the relation between...
article 1999
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TNO Arbeid (author), Houtman, I. (author), Kornitzer, M. (author), de Smet, P. (author), Koyuncu, R. (author), de Backer, G. (author), Pelfrene, E. (author), Romon, M. (author), Boulenguez, C. (author), Ferrario, M. (author), Origgi, G. (author), Sans, S. (author), Perez, I. (author), Wilhelmsen, L. (author), Rosengren, A. (author), Isacsson, S.O. (author), Östergren, P.O. (author)
Background: The motives, objectives and design of a multicentre prospective study on job stress, absenteeism and coronary heart disease in Europe (the JACE study) is presented in this paper. Some specific gaps in the reviewed literature are explicitly tapped into by the JACE study. Its objectives are i) to compare the distributions of the...
article 1999
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Schaafsma, G. (author), Meuling, W.J.A. (author), van Dokkum, W. (author), Bouley, C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To investigate in adult male volunteers the effect of a new fermented milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids. Design: Randomized placebo-controlled double-blind two-way cross over trial with two treatment periods of three weeks, separated by a wash-out period of one...
article 1998
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van Poppel, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: Fatty Acids
article 1998
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Gaubius Instituut TNO (author), van Vlijmen, B.J.M. (author), Pearce, N.J. (author), Bergö, M. (author), Staels, B. (author), Yates, J.W. (author), Gribble, A.D. (author), Bond, B.C. (author), Hofker, M.H. (author), Havekes, L.M. (author), Groot, P.H.E. (author)
Apolipoprotein (APO) E*3-Leiden mice with impaired chylomicron and VLDL (very low density lipoprotein) remnant metabolism display hyperlipidaemia and atherosclerosis. In the present study, these mice were used for testing the hypolipidaemic effect of two marketed agents, lovastatin (CAS 75330-75-5) and gemfibrozil (CAS 25812-30-0) as well as a...
article 1998
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Gevers Leuven, J.A. (author), TNO Preventie en Gezondheid (author)
Searching for familial hypercholesterolaemia (FH) in children is useful only if efficacious treatment is to be administered shortly and if there are relatives with ischaemic heart disease at very early ages. In all other cases, the (psychological) drawbacks probably outweigh the doubtful benefit of early intervention. The search for the major...
article 1997
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van de Vijver, L.P.L. (author), van Duyvenvoorde, W. (author), Buytenhek, R. (author), van der Laarse, A. (author), Kardinaal, A.F.M. (author), van den Berg, H. (author), Princen, H.M.G. (author)
article 1997
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van der Bom, J.G. (author), de Maat, M.P.M. (author), Bots, M.L. (author), Hofman, A. (author), Kluft, C. (author), Grobbee, D.E. (author), Gaubius Instituut TNO (author)
As evidence accumulates to implicate fibrinogen as a risk indicator for cardiovascular disease, it is of interest to study its seasonal variation. A population based cross-sectional study was performed among participants of the Rotterdam Study, a cohort of 7983 men and women, aged 55 years and over. Fibrinogen levels were measured by the...
article 1997
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Kockx, M. (author), de Maat, M.P.M. (author), Knipscheer, H.C. (author), Kastelein, J.P. (author), Kluft, C. (author), Princen, H.M.G. (author), Kooistra, T. (author), Gaubius Instituut TNO (author)
Evaluation of fibrate treatment in humans has focused primarily on its anti-lipidaemic effects. A potentially favourable haemostasis-modulating activity of fibrates has also been recognized but the data are not consistent. We sought to learn more about this variability by examining the effects of gemfibrozil and ciprofibrate on plasma levels of...
article 1997
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Groot, P.H.E. (author), van Vlijmen, B.J.M. (author), Benson, G.M. (author), Hofker, M.H. (author), Schiffelers, R. (author), Vidgeon-Hart, M. (author), Havekes, L.M. (author), Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Frythe, Welwyn, Hertfordshire, United Kingdom TNO-Prevention and Health, Gaubius Laboratory, Leiden, Netherlands SmithKline Beecham Pharmaceuticals, Frythe, Welwyn (Herts), AL6 9AR, United Kingdom TNO Preventie en Gezondheid (author)
Transgenic mice overexpressing the human dysfunctional apolipoprotein E variant, APOE*3 Leiden, develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. In the present study, we investigated the effects of diet composition and feeding period on serum cholesterol exposure and the amount of atherosclerosis in the aortic...
article 1996
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Jong, M.C. (author), Dahlmans, V.E.H. (author), van Gorp, P.J.J. (author), Breuer, M.L. (author), Mol, M.J.T.M. (author), van der Zee, A. (author), Frants, R.R. (author), Hofker, M.H. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Transgenic mice overexpressing human APOE*3Leiden are highly susceptible to diet-induced hyperlipoproteinemia and atherosclerosis due to a defect in hepatic uptake of remnant lipoproteins. In addition to the human APOE*3Leiden gene, these mice carry the human APOC1 gene (APOE*3Leiden- C1). To investigate the possible effect of simultaneous...
article 1996
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Hasler-Rapacz, J. (author), Kempen, H.J. (author), Princen, H.M.G. (author), Kudchodkar, B.J. (author), Lacko, A. (author), Rapacz, J. (author), Gaubius Instituut TNO (author)
Familial hypercholesterolemia (FHC) in swine, which resembles human familial combined hyperlipidemia, is a complex lipid and lipoprotein disorder associated with the development of severe coronary lesions similar to those occurring in advanced human coronary disease. The disorder is characterized by elevated plasma total cholesterol (TC),...
article 1996
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van Ree, J.H. (author), Hofker, M.H. (author), van den Broek, J.A.A. (author), van Deursen, J.M.A. (author), van der Boom, H. (author), Frants, R.R. (author), Wieringa, B. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
The function of apolipoprotein (apo) C1 in vivo is not well understood. From in vitro studies it has been reported that an excess of apoC1 relative to apoE inhibits receptor-mediated uptake of remnant lipoproteins. In order to gain a better understanding of the role of apoC1 in lipoprotein metabolism in vivo, we have generated apoC1-deficient...
article 1995
Searched for: subject%3A%22Cholesterol%255C%2Bblood%255C%2Blevel%22
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