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- Rops, C.M. (author), Boerboom, P. (author) public lecture 2023
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Eslami Amirabadi, H. (author), Donkers, J.M. (author), Wieringa, E. (author), Ingenhut, B. (author), Pieters, L. (author), Stevens, L. (author), Donkers, T. (author), Westerhout, J. (author), Masereeuw, R. (author), Bobeldijk-Pastorova, I. (author), Nooijen, I. (author), van de Steeg, E. (author)The majority of intestinal in vitro screening models use cell lines that do not reflect the complexity of the human intestinal tract and hence often fail to accurately predict intestinal drug absorption. Tissue explants have intact intestinal architecture and cell type diversity, but show short viability in static conditions. Here, we present a...article 2022
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Ostendorf, R. (author), Erpelinck, S. (author)The Organ-on-a-Chip Early Research Program enables TNO to offer state-of-the-art technologies that help the pharmaceutical industry advance drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model human tissue functioning and accelerate compound development and testing. The Intestinal Epithelial Barrier...other 2022
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Ostendorf, R. (author)The Organ-on-a-Chip Early Research Program (ERP) has enabled TNO to offer a number of state-of-the-art technologies to help pharmaceutical and biotech companies advance and accelerate drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model the workings of human tissue and accelerate compound development...other 2022
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- Liu, Y.Y. (author), Philips, S.G.J. (author), Orona, L.A. (author), Samkharadze, N. (author), McJunkin, T. (author), Macquarrie, E.R. (author), Eriksson, M.A. (author), Vandersypen, L.M.K. (author), Yacoby, A. (author) article 2021
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Donkers, J.M. (author), Eslami Amirabadi, H. (author), van de Steeg, E. (author)Over the past decade, microfluidic intestine-on-a-chip models have been emerging as a novel platform to study intestinal function in health and disease. These microphysiological systems surpass conventional in vitro intestinal model systems, as they add microenvironmental context in the form of mechanical cues or by the incorporation of multiple...article 2021
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van Berlo, D. (author), van de Steeg, E. (author), Amirabadi, H.E. (author), Masereeuw, R. (author)The development of new medicines suffers from attrition, especially in the development pipeline. Eight out of nine drug candidates entering the clinical testing phase fail, mostly due to poor safety and efficacy. The low predictive value of animal models, used in earlier phases of drug development, for effects in humans poses a major problem. In...article 2021
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Wolterink, T.A.W. (author), Buijs, R.D. (author), Gerini, G. (author), Verhagen, E. (author), Koenderink, A.F. (author)Overlay measurements are a critical part of modern semiconductor fabrication, but overlay targets have not scaled down in the way devices have. In this work, we produce overlay targets with very small footprint, consisting of just a few scattering nanoparticles in two separate device layers. Using moiré patterns to deterministically generate...article 2021
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Rahman, S. (author), Ghiboud, M. (author), Donkers, J.M. (author), van de Steeg, E. (author), van Tol, E.A.F. (author), Hakvoort, T.B.M. (author), de Jonge, W.J. (author)Over the past years, several preclinical in vitro and ex vivo models have been developed that helped to understand some of the critical aspects of intestinal functions in health and disease such as inflammatory bowel disease (IBD). However, the translation to the human in vivo situation remains problematic. The main reason for this is that these...article 2021
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Dopsa, D.D. (author), Kronemeijer, A.J. (author), Gelinck, G. (author)Integrating electronics with organ-on-chip-related technologies can assist in the development of better medicines, such as those for neurodegenerative and cardiovascular diseases. Holst Centre looks to contribute its flexible electronics and manufacturing expertise to the ecosystem. The early publication: The 3 dimensions of Organ-on-a-chip,...other 2020
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Langerak, N. (author), Ahmed, H.M.M. (author), Li, Y. (author), Middel, I.R. (author), eslami Amirabadi, H. (author), Malda, J. (author), Masereeuw, R. (author), van Roij, R. (author)Microphysiological systems have potential as test systems in studying the intestinal barrier, in which shear stress is critical for the differentiation of Caco-2 cells into enterocytes. The most commonly used in vitro gut model for intestinal barrier studies is based on trans-well cultures. Albeit useful, these culture systems lack physiological...article 2020
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- Bouwmeester, H. (author), Withoff, S. (author), van de Steeg, E. (author) bookPart 2020
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- Stokman, G. (author), Hanemaaijer, R. (author), van de Water, B. (author) bookPart 2020
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Zheng, G. (author), Samkharadze, N. (author), Noordam, M.L. (author), Kalhor, N. (author), Brousse, D. (author), Sammak, A. (author), Scappucci, G. (author), Vandersypen, L.M.K. (author)Silicon spin qubits are one of the leading platforms for quantum computation1,2. As with any qubit implementation, a crucial requirement is the ability to measure individual quantum states rapidly and with high fidelity. Since the signal from a single electron spin is minute, the different spin states are converted to different charge states3,4....article 2019
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Papadopoulos, N. (author), Qiu, W. (author), Ameys, M. (author), Smout, S. (author), Willegems, M. (author), Deroo, F. (author), van der Steen, J.L. (author), Kronemeijer, A.J. (author), Dehouwer, M. (author), Mityashin, A. (author), Gehlhaar, R. (author), Myny, K. (author)Capacitive touchscreens are increasingly widespread, featuring in mobile phones and tablets, as well as everyday objects such as cars and home appliances. As a result, the interfaces are uniquely placed to provide a means of communication in the era of the Internet of Everything. Here, we show that commercial touchscreens can be used as reader...article 2019
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Eslami Amirabadi, H. (author), Wierenga, E. (author), Stevens, L.J. (author), Donkers, J. (author), Donkers, T. (author), Ingenhut, B.L.J. (author), Usta, B. (author), Pieters, L. (author), Gröllers, M. (author), Nooijen, I.H.G. (author), Erpelinck, S.L.A. (author), Schuren, F. (author), Masereeuw, R. (author), van de Steeg, E. (author)The majority of screening and predictive models do not reflect the physiology of the human intestinal tract since they show major limitations to include the processes that determine the oral bioavailability1,2. A major drawback of current intestinal models is the use of single cell lines and the static environment, which is in contrast with the...public lecture 2019
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Yepes, C. (author), Gandini, E. (author), Dijk, R.V. (author), Bruning, F. (author), Maalderink, H. (author), Monni, S. (author), van Vliet, F.E. (author)A 24 GHz antenna design for miniaturized FMCW radar is presented. The antenna was manufactured with additive manufacturing technology at TNO. The characterization of the polymer material used in the fabrication was carried out and the measurement results of the antenna are presented in this work. A good agreement between simulations and...conference paper 2018
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van Wanum, M. (author), de Boer, L. (author), van Vliet, F.E. (author)This paper describes a fractional-N PLL IC with absolute phase control utilizing an on-chip loop-filter. The frequency range is 2.6 to 3.5 GHz, which covers one of the bands for future low-band 5G telecommunication systems. For phased-array operation a compact form-factor is needed as the space available for the complete front-end is limited by...conference paper 2018
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Arutinov, G. (author), Giesbers, M. (author), van Waalwijk van Doorn, S. (author), Chiappini, F. (author), Kusters, R. (author), van den Brand, J. (author)This paper reports the use of Laser-induced Forward Transfer (LIFT) technology for printing of multilayer flexible circuitries and the fabrication of micro-bumps for flip-chip bonding of packaged LEDs and bare die microcomponents. Bonding of passive and functional surface mount devices (SMD) on low-temperature polyethylene terephthalate (PET)...conference paper 2018
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Yepes, J.C. (author), Gandini, E. (author), van Dijk, R. (author), Bruning, F. (author), Maalderink, H. (author), Morini, S. (author), van Vliet, F.E. (author)A 24 GHz antenna design for miniaturized FMCW radar is presented. The antenna was manufactured with additive manufacturing technology at TNO. The characterization of the polymer material used in the fabrication was carried out and the measurement results of the antenna are presented in this work. A good agreement between simulations and...conference paper 2018