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Pirmana, V. (author), Alisjahbana, A.S. (author), Yusuf, A.A. (author), Hoekstra, R. (author), Tukker, A. (author)The use of fossil fuel-based vehicles may gradually be replaced by electric vehicles in the future. The trend indicates that the number of users of electric vehicles, especially electric cars, continues to increase. Indonesia is well-positioned to take advantage of this opportunity as it has the world’s largest nickel reserves, an essential raw...article 2023
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Thurkow, M. (author), Banzhaf, S. (author), Burler, T. (author), Pultz, J. (author), Schaap, M. (author)Millions of people are exposed to enhanced levels of nitrogen dioxide in urbanized areas, leading to severe health effects. Moreover, nitrogen oxides contribute to the formation of ozone and particulate matter, and as such have wider health related impacts. A substantial reduction of nitrogen oxides may offer considerable health benefits for the...article 2023
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Tosato, A. (author), Levajac, V. (author), Wang, J.Y. (author), Boor, C.J. (author), Borsoi, F. (author), Botifoll, M. (author), Borja, C.N. (author), Marti-Sánchez, S. (author), Arbiol, J. (author), Sammak, A. (author), Veldhorst, M. (author), Scappucci, G. (author)The co-integration of spin, superconducting, and topological systems is emerging as an exciting pathway for scalable and high-fidelity quantum information technology. High-mobility planar germanium is a front-runner semiconductor for building quantum processors with spin-qubits, but progress with hybrid superconductor-semiconductor devices is...article 2023
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de Bruin-Hoegée, J.M. (author), Schoorl, J. (author), Zoon, P. (author), van der Schans, M.J. (author), Noort, D. (author), van Asten, A.C. (author)Plastic materials are often found on crime scenes in improvised explosive devices. Determining the trace-elemental composition of polymer parts may yield discrimination between samples from different sources. Although quantitative laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) is well established for forensic glass...article 2023
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de Bruin-Hoegee, J.M. (author), Fidder, A. (author), van Groningen, T. (author), van der Schans, M.J. (author), Noort, D. (author), van Asten, A.C. (author)The analysis of biomedical samples is important for the investigation of the alleged exposure to chemical warfare agents. The present study aims to use dried blood spots for portable detection and laboratory verification of organophosphate poisoning. After in-vitro incubation of blood with Novichok A-230, A-232 and A-234 and sarin, a volume of...article 2023
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Suchowerska, A.K. (author), Stokman, G. (author), Palmer, J.T. (author), Coghlan, P.A. (author), Pieterman, E.J. (author), Keijzer, N. (author), Lambert, G. (author), Chemello, K. (author), Jaafar, A.K. (author), Parmar, J. (author), Yan, L. (author), Tong, Y. (author), Mu, L. (author), Princen, H.M.G. (author), Bonnar, J. (author), Evison, B.J. (author)Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibits the clearance of low-density lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly binding with the LDL receptor (LDLR) and sending the receptor for lysosomal degradation. As the interaction promotes elevated plasma LDL-C levels, and therefore a predisposition to...article 2022
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Timmermans, R.M.A. (author), van Pinxteren, D. (author), Kranenburg, R. (author), Hendriks, C. (author), Fomba, K.W. (author), Herrmann, H. (author), Schaap, M. (author)Due to its serious health impact particulate matter is one of the air pollutants subject to abatement policies. Information on the main sources responsible for high concentrations of pollutants is therefore crucial to enable effective policy measures. In this study we compared two different methods for attribution of particulate matter...article 2022
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Islam, M.F. (author), Schot, P.P. (author), Dekker, S.C. (author), Griffioen, J. (author), Middelkoop, H. (author)The Ganges–Brahmaputra–Meghna delta in Bangladesh is one of the largest and most densely popu lated deltas in the world and is threatened by relative sea level rise (RSLR). Renewed sediment deposition through tidal river management (TRM), a controlled flooding with dike breach, inside the lowest parts of the delta polders (so called beels) can...article 2022
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Zevenbergen, J.F. (author), van den Elshout, J.J.M.H. (author), Koning, R. (author), den Otter, J.H. (author), Olde, M.C. (author), de Koster, S.A.L. (author), van Lingen, J.N.J. (author)To ensure that so-called critical compounds, which are substances that are produced by only one or in the worst case no Western supplier, are available for the European space sector, the transition of batch-wise to continuous processing can guarantee independent access to space. Already widely accepted in the pharmaceutical industry, it is still...conference paper 2022
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Timmermans, R.M.A. (author), Segers, A.J. (author), Dammers, E. (author), Jorba, O. (author), Bowdalo, D. (author), Fagerli, H. (author), Valdebenito, A. (author), Colette, A. (author), Descombes, G. (author), Kouznetsov, R. (author), Uppstu, A. (author), Schaap. M., (author)Within Copernicus Atmosphere Monitoring Service (CAMS) an ensemble of 9 chemistry transport models provides daily analyses and forecasts, as well as annual reanalyses over Europe. The CAMS_61 project was developed to provide development plans, guidelines and tools for the upgrade of the models within this regional air quality service. In this...conference paper 2022
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Ramacher, M.O.P. (author), Kakouri, A. (author), Speyer, O. (author), Feldner, J. (author), Karl, M. (author), Timmermans, R.M.A. (author), Dernier van der Gon, H.A.C. (author), Kuenen, J.J.P. (author), Gerasopoulos, E. (author), Athanasopoulou, E. (author)As cities are growing in size and complexity, the estimation of air pollution exposure requires a detailed spatial representation of air pollution levels, rather than homogenous fields, provided by global- or regional-scale models. A critical input for city-scale modeling is a timely and spatially resolved emission inventory. Bottom–up...article 2021
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Kuper, C.F. (author), Pieters, R.H.H. (author), van Bilsen, J.H.M. (author)The thoracic and peritoneal cavities are lined by serous membranes and are home of the serosal immune system. This immune system fuses innate and adaptive immunity, to maintain local homeostasis and repair local tissue damage, and to cooperate closely with the mucosal immune system. Innate lymphoid cells (ILCs) are found abundantly in the...article 2021
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de Bruin-Hoegee, J.M. (author), Kleiweg, D. (author), Noort, D. (author), van Asten, A.C. (author)Chemical attribution typically aims to establish a link between material found at a crime scene and a person, location or other evidence. In the field of illicit drugs, chemical attribution signatures are usually impurity profiles. Extending these to metabolized samples would create new possibilities in forensic investigations. The present study...article 2021
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Garcia, A.C. (author), Sánchez Martínez, C. (author), Bakker, I.J. (author), Goetheer, E.L.V. (author)Herein, we describe a study of the electrochemical reduction of oxalic and glyoxylic acids toward a feasible green and sustainable production of tartaric acid in aqueous and/or acetonitrile solvent using silver and lead electrodes. Our results show that on the silver electrode, for both oxalic acid and glyoxylic acid, the reduction reaction is...article 2020
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Verhoeckx, K. (author), lindholm Bøgh, K. (author), Constable, A. (author), Epstein, M.M. (author), hoffmann Sommergruber, K. (author), Holzhauser, T. (author), Houben, G. (author), Kuehn, A. (author), Roggen, E. (author), O'Mahony, L. (author), Remington, B. (author), Crevel, R. (author)The growing world population and increased pressure on agricultural resources are driving a shortage of dietary protein sources. As a result, industry is developing more sustainable novel food protein sources such as insects, algae and duckweed and using new processing techniques. Consumer exposure to these novel or processed proteins, could...article 2020
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Remington, B.C. (author), Blom, W.M. (author), Bassa, B. (author), Koppelman, S.J. (author)Allergic reactions to meals consumed outside the home are common and can be severe and sometimes fatal. Objective. To quantify the risk reduction potentially achieved by increasing an individual’s threshold sensitivity to peanut (such as by means of immunotherapy) in scenarios of peanut exposure through shared kitchen materials in a restaurant...article 2020
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Directing nitrogen-doped carbon support chemistry for improved aqueous phase hydrogenation catalysisBosilj, M. (author), Rustam, L. (author), Thomann, R. (author), Melke, J. (author), Fischer, A. (author), White, R.J. (author)Selective hydrogenations in the aqueous phase are an important transformation in the context of developing biorefinery concepts. In this report the application and optimisation of nitrogen-doped carbon (NDC) supported Pd nanoparticles as hydrogenation catalysts is discussed in the context of directing support (e.g. N) chemistry for improved...article 2020
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Bezemer, K. (author), McLennan, L. (author), Hessels, R. (author), Schoorl, J. (author), van den Elshout, J.J.M.H. (author), van der Heijden, A.E.D.M. (author), Hulsbergen, A. (author), Koeberg, M. (author), Busby, T. (author), Yevdokimov, A. (author), Rijke, E. (author), Schoenmakers, P. (author), Smith, J. (author), Oxley, J. (author), van Asten, A. (author)In this follow-up study the collaboration between two research groups from the USA and the Netherlands was continued to expand the framework of chemical attribution for the homemade explosive erythritol tetranitrate (ETN). Isotope ratio mass spectrometry (IRMS) analysis was performed to predict possible links between ETN samples and its...article 2020
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Desprez, B. (author), Birk, B. (author), Blaauboer, B. (author), Boobis, A. (author), Carmichael, P. (author), Cronin, M.T.D. (author), Curie, R. (author), Daston, G. (author), Hubesch, B. (author), Jennings, P. (author), Klaric, M. (author), Kroese, D. (author), Mahony, C. (author), Ouédraogo, G. (author), Piersma, A. (author), Richarz, A.N. (author), Schwarz, M. (author), van Benthem, J. (author), van de Water, B. (author), Vinken, M. (author)Repeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to chemicals. Non-animal approaches have gained importance in the last decades because of ethical considerations as well as due to scientific reasons calling for more human-based strategies. A critical aspect of this...article 2019
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Bisselink, R.J.M. (author), Crockatt, M. (author), Zijlstra, M. (author), Bakker, I.J. (author), Goetheer, E.L.V. (author), Slaghek, T.M. (author), van Es, D.S. (author)The electrochemical production of valeric acid from the renewable bio-based feedstock levulinic acid has the potential to replace the oxo-process, which uses fossil-based feedstock 1-butylene. The electrochemical reduction of the ketone functionality in levulinic acid using lead or mercury cathodes has already been known for over 100 years....article 2019