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de Bruin-Hoegée, J.M. (author), Lamriti, L. (author), Langenberg, J.P. (author), Olivier, R.C.M. (author), Chau, L.F. (author), van der Schans, M.J. (author), Noort, D. (author), van Asten, A.C. (author)The continuing threats of military conflicts and terrorism may involve the misuse of chemical weapons. The present study aims to use environmental samples to find evidence of the release of such agents at an incident scene. A novel approach was developed for identifying protein adducts in plants. Basil (Ocimum basilicum), bay laurel leaf (Laurus...article 2023
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Holmgren, K.H. (author), Hakulinen, H. (author), Norlin, R. (author), de Bruin-Hoegée, J.M. (author), Spiandore, M. (author), See, S.Q.S. (author), Webster, R. (author), Jacques, K.L. (author), Mauravaara, L. (author), Ang, L.H. (author), Evans, C.P. (author), Ovenden, S. (author), Noort, D. (author), Delaporte, G. (author), Dahlén, J. (author), Fraga, C.G. (author), Vanninen, P. (author), Åstot, C. (author)An interlaboratory evaluation of a chemical profiling method for a nerve agent precursor was performed by eight chemical analytical laboratories with a wide global distribution. A set of chemical attribution signatures (i.e. impurities) present in methylphosphonic dichloride (DC) were analysed by gas chromatography-mass spectrometry (GC/MS). The...article 2023
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Santonen, T. (author), Mahiout, S. (author), Alvito, P. (author), Apel, P. (author), Bessems, J. (author), Bil, W. (author), Borges, T. (author), Bose-O'Reilly, S. (author), Buekers, J. (author), Canas Portilla, A.I. (author), Calvo, A.C. (author), de Alba González, M. (author), Dominguez-Morueco, N. (author), Lopez, M.E. (author), Falnoga, I. (author), Gerofke, A. (author), Caballero, M.D.C.G. (author), Horvat, M. (author), Huuskonen, P. (author), Kadikis, N. (author), Kolossa-Gehring, M. (author), Lange, R. (author), Louro, H. (author), Martins, C. (author), Meslin, M. (author), Niemann, L. (author), Diaz, S.P. (author), Plichta, V. (author), Porras, S.P. (author), Rousselle, C. (author), Scholten, B. (author), Silva, M.J. (author), Šlejkovec, Z. (author), Tratnik, J.S. (author), Joksic, A.Š. (author), Tarazona, J.V. (author), Uhl, M. (author), van Nieuwenhuyse, A. (author), Viegas, S. (author), Vinggaard, A.M. (author), Woutersen, M. (author), Schoeters, G. (author)One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge...article 2023
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van Damme, I.M. (author), Mestres-Fitó, P. (author), Ramaker, H.J. (author), Hulsbergen, A.W.C. (author), van der Heijden, A.E.D.M. (author), Kranenburg, R.F. (author), van Asten, A.C. (author)There is an ongoing forensic and security need for rapid, on-scene, easy-to-use, non-invasive chemical identification of intact energetic materials at pre-explosion crime scenes. Recent technological advances in instrument miniaturization, wireless transfer and cloud storage of digital data, and multivariate data analysis have created new and...article 2023
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Pirmana, V. (author), Alisjahbana, A.S. (author), Yusuf, A.A. (author), Hoekstra, R. (author), Tukker, A. (author)The use of fossil fuel-based vehicles may gradually be replaced by electric vehicles in the future. The trend indicates that the number of users of electric vehicles, especially electric cars, continues to increase. Indonesia is well-positioned to take advantage of this opportunity as it has the world’s largest nickel reserves, an essential raw...article 2023
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Difrancesco, S. (author), van Baardewijk, J.U. (author), Cornelissen, A.S. (author), Varon, C. (author), Hendriks, R.C. (author), Brouwer, A.M. (author)Wearable sensors offer new opportunities for the early detection and identification of toxic chemicals in situations where medical evaluation is not immediately possible. We previously found that continuously recorded physiology in guinea pigs can be used for early detection of exposure to an opioid (fentanyl) or a nerve agent (VX), as well as...article 2023
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Säde, S. (author), Delaporte, G. (author), Fraga, C.G. (author), Hakulinen, H. (author), Höjer Holmgren, K. (author), Spiandore, M. (author), Åstot, C. (author), Akmeemana, A. (author), de Bruin-Hoegée, J.M. (author), Doward, J. (author), Jacques, K. (author), Kesah, S.A. (author), See, S. (author), Thomson, S. (author), Flinck, J. (author), Kalliovirta, L. (author), Vanninen, P. (author)A new quality control (QC) test sample for gas chromatography-mass spectrometry (GC-MS) was created and analysed to test the comparability and repeatability of chemical forensics results within the Organisation for the Prohibition of Chemical Weapons (OPCW)-designated laboratories. The QC test sample was designed in collaboration between four...article 2023
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de Bruin-Hoegée, J.M. (author), Schoorl, J. (author), Zoon, P. (author), van der Schans, M.J. (author), Noort, D. (author), van Asten, A.C. (author)Plastic materials are often found on crime scenes in improvised explosive devices. Determining the trace-elemental composition of polymer parts may yield discrimination between samples from different sources. Although quantitative laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) is well established for forensic glass...article 2023
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Ghassabian, A. (author), van den Dries, M.A. (author), Trasande, L. (author), Lamballais, S. (author), Spaan, S. (author), Martinez-Moral, M.P. (author), Kannan, K. (author), Jaddoe, V.W.V. (author), Engel, S.M. (author), Pronk, A. (author), White, T. (author), Tiemeier, H. (author), Guxens, M. (author)Exposure to phthalates, used as plasticizers and solvents in consumer products, is ubiquitous. Despite growing concerns regarding their neurotoxicity, brain differences associated with gestational exposure to phthalates are understudied. We included 775 mother-child pairs from Generation R, a population-based pediatric neuroimaging study with...article 2023
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de Bruin-Hoegee, J.M. (author), Fidder, A. (author), van Groningen, T. (author), van der Schans, M.J. (author), Noort, D. (author), van Asten, A.C. (author)The analysis of biomedical samples is important for the investigation of the alleged exposure to chemical warfare agents. The present study aims to use dried blood spots for portable detection and laboratory verification of organophosphate poisoning. After in-vitro incubation of blood with Novichok A-230, A-232 and A-234 and sarin, a volume of...article 2023
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Liebig-Gonglach, M. (author), Neunhäuserer, L. (author), Kuenen, J.J.P. (author), Hoffmann, B. (author), Soppa, V. (author), Diegmann, V. (author), Hornberg, C. (author)Objectives: The study estimated the environmental burden of disease (EBD) attributable to a long-term exposure of the population to nitrogen dioxide (NO2) and fine particulate matter (PM2.5) emissions from hard coal- and lignite-fired power plants in Germany for the year 2015. Methods: The contribution of coal-fired power plants to the total air...article 2023
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de Bruin-Hoegée, J.M. (author), Alkema, D.P.W. (author), Busker, R.W. (author), Joosen, M.J.A. (author), van Wuijckhuijse, A.L. (author)Objectives: Deliberate or accidental release of chemical treat agents in the aerosol form can cause an inhalation hazard. Since the relationship between aerosol properties and health hazards is poorly understood, research into the toxicological consequences of exposure to aerosols is needed. The aim of the present study was to improve the...article 2023
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Karakitsios, S. (author), Maggos, T. (author), Busker, R.W. (author), Armand, P. (author), Bartzis, J.G. (author)The overarching objective of the ERNCIP “Detection of Indoor Airborne Chemical & Biological Agents” Thematic Group (TG) is to strengthen resilience of critical infrastructure against airborne CB threats by improvement of detection capabilities. The subsidiary aim of the research described in this technical report is to develop knowledge on the...report 2022
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Shahmohammadi, M.S. (author), Parker, L.A. (author), Henke, S. (author), Urbanus, J.H. (author)Microplastics are a growing environmental and toxicological concern, having been found in the remotest locations of the earth and within multiple organs of the human body. However, the scale of the problem is not yet fully known as the smallest micro- and nanoplastics (MNPs) cannot accurately be measured due to limitations in measurement and...article 2022
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- Durán Jiménez, D. (author), de Bruin-Hoegee, J.M. (author), Alkema, D.P.W. (author), Noort, D. (author), Busker, R.W. (author), van Wuijckhuijse, A.L. (author) conference paper 2022
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Luo, J. (author), Moncada, J. (author), Ramirez, A. (author)Incorporating (operational) flexibility into process design has been a key approach to cope with uncertainties. The increasing penetration of renewables and the need for developing new low-carbon technologies will increase the demand for flexibility in chemical processes. This paper presents a state-of the-art review focusing on the origin,...article 2022
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Verhoeven, G. (author), van der Holst, B. (author), Sharma, S. (author), Kok, K. (author)Due to the increasing penetration of renewablebased distributed energy resources (DERs), the risks of congestion problems have been increasing in the Dutch distribution system. Traditionally, grid reinforcements were applied to prevent congestion, but due to shortages of technicians and due to long procedures, the use of flexibility from...conference paper 2022
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Fransman, W. (author), Arnone, M. (author), Borghi, F. (author), Cattaneo, A. (author), Cavallo, D.M. (author), Cherrie, J.W. (author), Franken, R. (author), Galea, K.S. (author), van der Haar, R. (author), Heussen, G.A.H. (author), Jensen, K.A. (author), Koponen, M. (author), Koppisch, D. (author), Kromhout, H. (author), Luo, KY.S. (author), McNally, K. (author), Säämänen, A. (author), Spinazzè, A. (author), van Tongeren, M. (author), Jeroen, (author), Vanoirbeek, J. (author), Verpaele, S. (author), Vetter, D. (author), Viegas, S. (author), Warren, N. (author)In this article, we have responded to the key statements in the article by Koivisto et al. (2022) that were incorrect and considered to be a biased critique on a subset of the exposure models used in Europe (i.e. ART and Stoffenmanager®) used for regulatory exposure assessment. We welcome scientific discussions on exposure modelling (as was done...article 2022
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Eslami-Mossallam, B. (author), Klein, M. (author), Smagt, C.V.D. (author), Sanden, K.V.D. (author), Jones Jr, S.K. (author), Hawkins, J.A. (author), Finkelstein, I.J. (author), Depken, M. (author)The S. pyogenes (Sp) Cas9 endonuclease is an important gene-editing tool. SpCas9 is directed to target sites based on complementarity to a complexed single-guide RNA (sgRNA). However, SpCas9-sgRNA also binds and cleaves genomic off-targets with only partial complementarity. To date, we lack the ability to predict cleavage and binding activity...article 2022
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Detz, R.J. (author), van der Zwaan, B. (author)Successful deployment of renewable fuel production requires substantial cost reduction along the entire value chain of the underlying manufacturing routes. To improve their performance, renewable fuel pro duction technologies should follow a cost-reducing learning curve. In this article, we adopt recent evi dence that learning-by-doing is...article 2022