Searched for: subject%3A%22Chemical%255C%2Bcompound%22
(1 - 17 of 17)
document
Grinberg, M. (author), Stöber, R.M. (author), Edlund, K. (author), Rempel, E. (author), Godoy, P. (author), Reif, R. (author), Widera, A. (author), Madjar, K. (author), Schmidt-Heck, W. (author), Marchan, R. (author), Sachinidis, A. (author), Spitkovsky, D. (author), Hescheler, J. (author), Carmo, H. (author), Arbo, M.D. (author), van de Water, B. (author), Wink, S. (author), Vinken, M. (author), Rogiers, V. (author), Escher, S. (author), Hardy, B. (author), Mitic, D. (author), Myatt, G. (author), Waldmann, T. (author), Mardinoglu, A. (author), Damm, G. (author), Seehofer, D. (author), Nüssler, A. (author), Weiss, T.S. (author), Oberemm, A. (author), Lampen, A. (author), Schaap, M.M. (author), Luijten, M. (author), van Steeg, H. (author), Thasler, W.E. (author), Kleinjans, J.C.S. (author), Stierum, R.H. (author), Leist, M. (author), Rahnenführer, J. (author), Hengstler, J.G. (author)
Correction to: Arch Toxicol (2014) 88:2261–2287 https://doi.org/10.1007/s00204-014-1400-x.
article 2022
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Heiniö, R.L. (author), Noort, M.W.J. (author), Katina, K. (author), Alam, S.A. (author), Sozer, N. (author), de Kock, H.L. (author), Hersleth, M. (author), Poutanen, K. (author)
Background: Wholegrain foods are known to be health-beneficial but their sensory characteristics may be a limiting factor for consumption. The scientific literature of factors influencing sensory quality of wholegrain foods is rather scarce. Scope and approach: Many cereals like rye, oats, barley and sorghum are actually used mainly as...
article 2016
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Muller, C. (author), Maldonado, A.G. (author), Varnek, A. (author), Creton, B. (author)
Each oil reservoir could be characterized by a set of parameters such as temperature, pressure, oil composition, and brine salinity, etc. In the context of the chemical enhanced oil recovery (EOR), the selection of high performance surfactants is a challenging and time-consuming task since this strongly depends on the reservoir's conditions. The...
article 2015
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Koster, S. (author), Leeman, W.R. (author), Verheij, E.R. (author), Dutman, A.E. (author), van Stee, L.L.P. (author), Munch Nielsen, L. (author), Ronsmans, S. (author), Noteborn, H. (author), Krul, L. (author)
A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult...
article 2015
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Grinberg, M. (author), Stöber, R.M. (author), Edlund, K. (author), Rempel, E. (author), Godoy, P. (author), Reif, R. (author), Widera, A. (author), Madjar, K. (author), Schmidt-Heck, W. (author), Marchan, R. (author), Sachinidis, A. (author), Spitkovsky, D. (author), Hescheler, J. (author), Carmo, H. (author), Arbo, M.D. (author), van de Water, B. (author), Wink, S. (author), Vinken, M. (author), Rogiers, V. (author), Escher, S. (author), Hardy, B. (author), Mitic, D. (author), Myatt, G. (author), Waldmann, T. (author), Mardinoglu, A. (author), Damm, G. (author), Seehofer, D. (author), Nüssler, A. (author), Weiss, T.S. (author), Oberemm, A. (author), Lampen, A. (author), Schaap, M.M. (author), Luijten, M. (author), van Steeg, H. (author), Thasler, W.E. (author), Kleinjans, J.C.S. (author), Stierum, R.H. (author), Leist, M. (author), Rahnenführer, J. (author), Hengstler, J.G. (author)
A long-term goal of numerous research projects is to identify biomarkers for in vitro systems predicting toxicity in vivo. Often, transcriptomics data are used to identify candidates for further evaluation. However, a systematic directory summarizing key features of chemically influenced genes in human hepatocytes is not yet available. To bridge...
article 2014
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Patlewicz, G. (author), Ball, N. (author), Becker, R.A. (author), Booth, E.D. (author), Cronin, M.T.D. (author), Kroese, D. (author), Steup, D. (author), van Ravenzwaay, B. (author), Hartung, T. (author)
Read-across is a data gap filling technique used within category and analogue approaches. It has been utilized as an alternative approach to address information requirements under various past and present regulatory programs such as the OECD High Production Volume Programme as well as the EU's Registration, Evaluation, Authorisation and...
article 2014
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Lubelli, B.A. (author), Nijland, T.G. (author), van Hees, R.P.J. (author), Hacquebord, A. (author), TNO Bouw en Ondergrond (author)
Salt crystallization is a common cause of damage to porous building materials. Recent research has shown that some chemical compounds may inhibit salt crystallization or alter the mode of crystallization, thus limiting salt damage development, provided that the inhibitor was introduced prior to salt crystallization. In this paper, a pilot study...
article 2010
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Vink, S.R. (author), Mikkers, J. (author), Bouwman, T. (author), Marquart, H. (author), Kroese, E.D. (author), TNO Kwaliteit van Leven (author)
REACH requests the exploration of alternative strategies for hazard identification before resorting to (in vivo) testing. Here, we combined read-across as non-testing strategy with a tiered exposure assessment for the risk characterisation of 1-methoxypropan-2-ol (PGME) as a representative for phase-in substances to be registered under REACH....
article 2010
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van Hemmen, J.J. (author), Marquart, H. (author), TNO Kwaliteit van Leven (author)
article 2009
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Buist, H.E. (author), Schaafsma, G. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
Quantification of skin absorption is an essential step in reducing the uncertainty of dermal risk assessment. Data from literature indicate that the relative dermal absorption of substances is dependent on dermal loading. Therefore, an internal exposure calculated with absorption data determined at a dermal loading not comparable to the actual...
article 2009
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Vinken, M. (author), Doktorova, T. (author), Ellinger-Ziegelbauer, H. (author), Ahr, H.-J. (author), Lock, E. (author), Carmichael, P. (author), Roggen, E. (author), van Delft, J. (author), Kleinjans, J. (author), Castell, J. (author), Bort, R. (author), Donato, T. (author), Ryan, M. (author), Corvi, R. (author), Keun, H. (author), Ebbels, T. (author), Athersuch, T. (author), Sansone, S.-A. (author), Rocca-Serra, P. (author), Stierum, R. (author), Jennings, P. (author), Pfaller, W. (author), Gmuender, H. (author), Vanhaecke, T. (author), Rogiers, V. (author), TNO Kwaliteit van Leven (author)
Recent changes in the European legislation of chemical-related substances have forced the scientific community to speed up the search for alternative methods that could partly or fully replace animal experimentation. The Sixth Framework Program project carcinoGENOMICS was specifically raised to develop omics-based in vitro screens for testing...
article 2008
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Arts, J.H.E. (author), Kuper, C.F. (author), TNO Kwaliteit van Leven (author)
At present, there are no widely applied or fully validated test methods to identify respiratory LMW allergens, i.e. compounds that are considered capable of inducing allergic asthma. Most tests have been investigated using strong respiratory allergens. Moreover, they are meant to detect the potential of a chemical to induce respiratory...
article 2007
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Freidig, A.P. (author), Dekkers, S. (author), Verwei, M. (author), Zvinavashe, E. (author), Bessems, J.G.M. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
Future EU legislations enforce a fast hazard and risk assessment of thousands of existing chemicals. If conducted by means of present data requirements, this assessment will use a huge number of test animals and will be neither cost nor time effective. The purpose of the current research was to develop methods to increase the acceptability of in...
article 2007
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Stierum, R. (author), Heijne, W. (author), Kienhuis, A. (author), van Ommen, B. (author), Groten, J. (author), TNO Kwaliteit van Leven (author)
Transcriptomics, proteomics and metabolomics are genomics technologies with great potential in toxicological sciences. Toxicogenomics involves the integration of conventional toxicological examinations with gene, protein or metabolite expression profiles. An overview together with selected examples of the possibilities of genomics in toxicology...
article 2005
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Poelmans, S. (author), de Wasch, K. (author), de Brabander, H.F. (author), van de Wiele, M. (author), Courtheyn, D. (author), van Ginkel, L.A. (author), Sterk, S.S. (author), Delahaut, Ph. (author), Dubois, M. (author), Schilt, R. (author), Nielen, M. (author), Vercammen, J. (author), Impens, S. (author), Stephany, R. (author), Hamoir, T. (author), Pottie, G. (author), van Poucke, C. (author), van Peteghem, C. (author)
In sports doping, as well in man as in horseracing, stanozolol (Stan) was abused and became the subject of metabolism research. Also in veterinary practice, stanozolol became an important misused anabolic steroid. Like most other anabolic steroids, stanozolol has poor gas chromatographic behavior. It is difficult to detect in urine, because of...
article 2002
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Cassee, F.R. (author), Groten, J.P. (author), van Bladeren, P.J. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A major objective of combination toxicology is to establish whether a mixture of chemicals will result in an effect similar to that expected on the basis of additivity. This requires understanding of the basic concepts of the combined toxicological action of the compounds of the mixture: simple similar action (dose addition), simple dissimilar...
article 1998
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Barak, R. (author), Ordentlich, A. (author), Barak, D. (author), Fischer, M. (author), Benschop, H.P. (author), de Jong, L.P.A. (author), Segall, Y. (author), Velan, B. (author), Shafferman, A. (author)
While non-reactivability of cholinesterase from their phosphyl conjugates (aging) is attributed to an unimolecular process involving loss of alkyl group from the phosphyl moiety, no conclusive evidence is available that this is the only reaction path and involvement of other post-inhibitory processes cannot be ruled out, To address this issue,...
article 1997
Searched for: subject%3A%22Chemical%255C%2Bcompound%22
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