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Jolani, S. (author), Debray, T.P.A. (author), Koffijberg, H. (author), van Buuren, S. (author), Moons, K.G.M. (author)Individual participant data meta-analyses (IPD-MA) are increasingly used for developing and validating multivariable (diagnostic or prognostic) risk prediction models. Unfortunately, some predictors or even outcomes may not have been measured in each study and are thus systematically missing in some individual studies of the IPD-MA. As a...article 2015
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Gallis, R. (author), Zwetsloot, G.I.J.M. (author)High Reliability Organizations (HRO’s) are organizations that constantly face serious and complex (safety) risks yet succeed in realising an excellent safety performance. In such situations acceptable levels of safety cannot be achieved by traditional safety management only. HRO’s manage safety risks in a specific way, supported by an associated...other 2014
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Luis, J.G. (author), Hernández, J.G. (author), Rodriguez, G.P. (author), Carcel, G.H. (author), Hofman, W. (author)Nowadays, logistics could make you purchase a book in Amazon and delivering it in 24-hours using a service from a logistics operator or a transport company. In a more complex scenario, an order could be traveling around the globe, passing from hand to hand between unknown actors for months. In most cases the client would not be notified in a...conference paper 2014
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Aguirre, M. (author), Ramiro-Garcia, J. (author), Koenen, M.E. (author), Venema, K. (author)This study investigated the stability and the activity of the microbiota from a single and a pool of donors in the TNO in vitro model of the colon (TIM-2 system). Our findings demonstrate the suitability of the preparation of a pool of fecal sample to be used for fermentation experiments. Chemicals/CAS: isobutyric acid, 5711-69-3, 79-31-2;...article 2014
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Davydenko, I. (author), Ehrler, V. (author), de Ree, D. (author), Lewis, A. (author), Tavasszy, L. (author)Improving the efficiency and sustainability of supply chains is a shared aim of the transport industry, its customers, governments as well as industry organisations. To optimize supply chains and for the identification of best practice, standards for their analysis are needed in order to achieve comparable evaluations. This need for an...article 2014
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Pruksasri, P. (author), van den Berg, J. (author), Hofman, W.J. (author), Tan, Y.H. (author)Secure and accurate transactions are vital to any large-scale business system in order to guarantee the reliability of the system to stakeholders in both the public and private sectors. In supply chain systems, however, a variety of information security shortcomings is currently occurring in several processes, for example, related to data...conference paper 2014
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Leijdekkers, A.G.M. (author), Aguirre, M. (author), Venema, K. (author), Bosch, G. (author), Gruppen, H. (author), Schols, H.A. (author)The in vitro fermentation characteristics of different classes of sugar beet pectic oligosaccharides (SBPOS) were studied using human and pig fecal inocula. The SBPOS consisted mainly of partially acetylated rhamnogalacturonan oligosaccharides and partially methyl-esterified/acetylated homogalacturonan oligosaccharides. Some SBPOS contained an...article 2014
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Grinberg, M. (author), Stöber, R.M. (author), Edlund, K. (author), Rempel, E. (author), Godoy, P. (author), Reif, R. (author), Widera, A. (author), Madjar, K. (author), Schmidt-Heck, W. (author), Marchan, R. (author), Sachinidis, A. (author), Spitkovsky, D. (author), Hescheler, J. (author), Carmo, H. (author), Arbo, M.D. (author), van de Water, B. (author), Wink, S. (author), Vinken, M. (author), Rogiers, V. (author), Escher, S. (author), Hardy, B. (author), Mitic, D. (author), Myatt, G. (author), Waldmann, T. (author), Mardinoglu, A. (author), Damm, G. (author), Seehofer, D. (author), Nüssler, A. (author), Weiss, T.S. (author), Oberemm, A. (author), Lampen, A. (author), Schaap, M.M. (author), Luijten, M. (author), van Steeg, H. (author), Thasler, W.E. (author), Kleinjans, J.C.S. (author), Stierum, R.H. (author), Leist, M. (author), Rahnenführer, J. (author), Hengstler, J.G. (author)A long-term goal of numerous research projects is to identify biomarkers for in vitro systems predicting toxicity in vivo. Often, transcriptomics data are used to identify candidates for further evaluation. However, a systematic directory summarizing key features of chemically influenced genes in human hepatocytes is not yet available. To bridge...article 2014
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Pruksasri, P. (author), van den Berg, J. (author), Hofman, W.J. (author)Global information systems are becoming more complex and dynamic everyday: huge amounts of data and messages through those systems show dynamically changing traffic patterns. Because of this, diagnosing when sub-systems are not working properly is difficult. System failures or errors in information exchange protocols sometimes happen and...conference paper 2014
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Vogt, L.M. (author), Meyer, D. (author), Pullens, G. (author), Faas, M.M. (author), Venema, K. (author), Ramasamy, U. (author), Schols, H.A. (author), de Vos, P. (author)Dietary fiber intake is associated with lower incidence and mortality from disease, but the underlying mechanisms of these protective effects are unclear.We hypothesized that β2→1-fructan dietary fibers confer protection on intestinal epithelial cell barrier function via Toll-like receptor 2 (TLR2), and we studied whether β2→1-fructan chain...article 2014
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Lukovac, S. (author), Belzer, C. (author), Pellis, L. (author), Keijser, B.J. (author), de Vos, W.M. (author), Montijn, R.C. (author), Roeselers, G. (author)The gut microbiota is essential for numerous aspects of human health. However, the underlying mechanisms of many host-microbiota interactions remain unclear. The aim of this study was to characterize effects of the microbiota on host epithelium using a novel ex vivo model based on mouse ileal organoids. We have explored the transcriptional...article 2014
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Moreau, L. (author), Hunter, A.J. (author), Velichko, A. (author), Wilcox, P.D. (author)In nondestructive testing, being able to remotely locate and size defects with good accuracy is an important requirement in many industrial sectors, such as the petrochemical, nuclear, and aerospace industries. The potential of ultrasonic guided waves is well known for this type of problem, but interpreting the measured data and extracting...article 2014
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Eckartz, S. (author), Emde, F. (author), Spitzer, A.M. (author), Stornebrink, M.H.M. (author)Dit artikel beschrijft een framework dat organisaties in een keten kan helpen om hun volwassenheid op het gebied van ketensamenwerking te bepalen en verbeteren. Immers, samenwerking in een informatieketen is vaak nog ingewikkelder dan samenwerking in een productieproces dat is gericht op het voortbrengen van fysieke goederen. Het raamwerk is...conference paper 2014
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Verneau, M. (author), van der Kamp, J. (author), Savelsbergh, G.J.P. (author), de Looze, M.P. (author)The present investigation assessed the putative benefits of reducing instructions for older adults' learning of an assembly task. Young and older adults had to build a product by assembling six components. Two groups practiced following instruction methods that differed in the degree of explicit information they conveyed about the correct...article 2014
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Minoglou, K. (author), San Segundo Bello, D. (author), Sabuncuoglu Tezcan, D. (author), Haspeslagh, L. (author), van Olmen, J. (author), Merry, B. (author), Cavaco, C. (author), Mazzamuto, F. (author), Toqué-Trésonne, I. (author), Moirin, R. (author), Brouwer, E.A.M. (author), Toccafondi, M. (author), Preti, G. (author), Rosmeulen, M. (author), de Moor, P. (author)Both ESA and the EC have identified the need for a supply chain of CMOS imagers for space applications which uses solely European sources. An essential requirement on this supply chain is the platformization of the process modules, in particular when it comes to very specific processing steps, such as those required for the manufacturing of...conference paper 2014
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Ramasamy, U.S. (author), Venema, K. (author), Gruppen, H. (author), Schols, H.A. (author)The aim of this study was to monitor cell wall polysaccharide (CWPs) utilization during fermentation by the human colonic microbiota in the TNO in vitro model of the colon (TIM-2). Chicory root pulp (CRP) and treated (ensiled) CRP (ECRP) containing four times more soluble pectin than CRP, were fermented in the model. After the adaptation phase...article 2014
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Eckartz, S. (author), Spitzer, A.M. (author)Collaborating in a value chain that delivers services is even more complex and information intensive than the collaboration in a physical goods value chain. Successfully managing the collaboration and underlying information chain is critical for the delivery of the end service. This paper gives insights into the challenges present in the domain...conference paper 2014
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Eckartz, S. (author), Katsma, C. (author)Nowadays, an increasing number of organizations in the supply chain are involved in business collaborations. The success of such collaborations is, among others, highly dependent on joint investment in IT system implementations. In this paper we will discuss how business cases can be used to determine the costs and benefits of such investments...conference paper 2014
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Ustailieva, E. (author)Current business and organisational practices have led to an increased importance of supply chains to business strategy as well as within national and global economies [1]. Nowadays, businesses increasingly rely on the outsourcing of parts of their activities and processes. Companies function and compete more and more on a supply chain level, in...other 2014