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van Dorp, E. (author), Los, M. (author), Dirven, P. (author), Sarton, E. (author), Valk, P. (author), Teppema, L. (author), Stienstra, R. (author), Dahan, A. (author), TNO Defensie en Veiligheid (author)Introduction: Exposure to a hypoxic environment has a deleterious effect on physiological and mental functions. We studied the effect of added inspired CO2 during artificially induced hypoxic normobaric hypoxia (oxygen saturation ∼80%) on complex task performance. Methods: In random order, 22 healthy volunteers were exposed to 3 gas mixtures for...article 2007
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Vuyk, J. (author), van den Bos, J. (author), Terhell, K. (author), de Bos, R. (author), Vletter, A. (author), Valk, P. (author), van Beuzekom, M. (author), van Kleef, J. (author), Dahan, A. (author), TNO Technische Menskunde (author)Acute mountain sickness is thought to be triggered by cerebral hypoxemia and be prevented by acetazolamide (Actz). The effect of Actz on cerebral oxygenation at altitude remains unknown. In 16 members of the 2005 Dutch Cho Oyu (8201 m, Tibet) expedition, the influence of Actz and exercise (750 mg PO daily) on heart rate, peripheral and regional...article 2006
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TNO Biomedical Instrumentation (author), van Lieshout, J.J. (author), Pott, F. (author), Madsen, P.L. (author), van Goudoever, J. (author), Secher, N.H. (author)Background and Purpose - When standing up causes dizziness, tensing of the leg muscles may alleviate the symptoms. We tested the hypothesis that leg tensing improves orthostatic tolerance via enhanced cerebral perfusion and oxygenation. Methods - In 10 healthy young adults, the effects of leg tensing on transcranial Doppler-determined middle...article 2001
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van Leeuwen, G.M.J. (author), Lagendijk, J.J.W. (author), van Leersum, B.J.A.M. (author), Zwamborn, A.P.M. (author), Hornsleth, S.N. (author), Kotte, A.N.T.J. (author), TNO Fysisch en Elektronisch Laboratorium (author)In this study we evaluated for a realistic head model the 3D temperature rise induced by a mobile phone. This was done numerically with the consecutive use of an FDTD model to predict the absorbed electromagnetic power distribution, and a thermal model describing bioheat transfer both by conduction and by blood flow. We calculated a maximum rise...article 1999
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Tulleken, C.A.F. (author), van Dieren, A. (author), ten Veen, J. (author), Lopes Da Silva, F.H. (author), TNO Workgroup Clin. Neurophysiol., Westeinde Hosp., The Hague, Netherlands Medisch Biologisch Laboratorium TNO (author)The local EEG, the local cerebral blood flow (lCBF), and the flow in the distal stump of the occluded middle cerebral artery were simultaneously recorded in 28 acute experiments in cats. Nembutal anesthesia was used eleven times, and Halothane anaesthesia 17 times. The recordings were made via platinum electrodes: 12 in the ischaemic hemisphere,...article 1982
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- Gaubius instituut TNO (author), Mosmans, P.C.M. (author), Jonkman, E.J. (author) article 1980
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Tulleken, C.A.F. (author), van Dieren, A. (author), Mollevanger, W.J. (author), van Eijck, P. (author), Inst. Med. Phys., TNO, Utrecht, Netherlands (author)In a group of 21 cats, the middle cerebral artery pressure (MCAP) was recorded by means of a catheter introduced into the artery at its origin, just distal to the occlusion. The effects of hypertension, hypercapnia, and hypocapnia were studied. In a group of five cats, both middle cerebral arteries (MCA) were catheterized and the pressure was...article 1978