Pages
- 1
- 2
- document
-
Bourgonje, A.R. (author), Offringa, A.K. (author), van Eijk, L.E. (author), Abdulle, A.E. (author), Hillebrands, J.L. (author), van der Voort, P.H.J. (author), van Goor, H. (author), van Hezik, E.J. (author)Significance: Hydrogen sulfide (H2S) is one of the three main gasotransmitters that are endogenously produced in humans and are protective against oxidative stress. Recent findings from studies focusing on coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), shifted our attention to a...article 2021
- document
-
Klein Velderman, M. (author), Pannebakker, F.D. (author), van Vliet, W. (author), Reijneveld, S.A. (author)Objective: Parental divorce has strong impacts on children. Evidence-based programs to support young children after parental divorce are rare. The U.S.-developed Children of Divorce Intervention Program (CODIP) is one of these. CODIP’s effectiveness outside the U.S. setting is to be further replicated. This study aimed at cultural adaptation of...article 2018
- document
-
Kamphuis, M. (author), van de Nieuwegiessen, A.I. (author), Span, P.M. (author)Background Dutch Youth health care is an easily accessible service where parents can ask for support for the healthy development of their children. The majority of the screenings and medical examinations show no abnormalities. Sometimes there is doubt about the severity of symptoms: the line between healthy variation and diseases or...article 2014
- document
-
Aguirre, M. (author), Jonkers, D.M.A.E. (author), Troost, F.J. (author), Roeselers, G. (author), Venema, K. (author)The aim of this study was to investigate the effect of galacto-oligosaccharides, lactulose, apple fiber and sugar beet pectin on the composition and activity of human colonic microbiota of lean and obese healthy subjects using an in vitro model of the proximal colon: TIM-2. Substrate fermentation was assessed by measuring the production of short...article 2014
- document
-
Iyer, V. (author), Waldram-Nienhuis, A. (author), Boland, N. (author), Kamphuis, M. (author)The Dutch Youth Act (2015) has to resolve serious problems among young people, prevent inappropriate medicalisation, and realise efficiency. Participation and empowerment are terms often used. At the moment Dutch youth healthcare doctors monitor children on a regular basis and assess situations based on the national Public Health Status and...article 2014
- document
-
Ainola, M. (author), Valleala, H. (author), Nykänen, P. (author), Risteli, J. (author), Hanemaaijer, R. (author), Konttinen, Y.T. (author), TNO Kwaliteit van Leven (author)Objective. The excellent poster painter Henri de Toulouse-Lautrec is the most famous patient with cathepsin K-deficient pycnodysostosis. Cathepsin K is believed to play a major role in osteoclast-driven bone resorption. In this study we explored the role of cathepsin K in bone resorption in a patient with a cathepsin K mutation causing...article 2008
- document
-
Goede, J. (author), Pierik, F.H. (author), Hack, W.W.M. (author), Algra, P.R. (author), TNO Bouw en Ondergrond (author)In three boys aged 15, 9, and 10 years respectively scrotal ultrasound revealed testicular microlithiasis (TM). Two boys were free of symptoms and one suffered from testicular pain. TM is characterized by multiple echogenic foci within the seminiferous tubules with no acoustic shadowing. The pathophysiology is largely unknown. In adult men, TM...article 2008
- document
-
TNO Kwaliteit van Leven (author), Goede, J. (author), Hack, W.W.M. (author), Sijstermans, K. (author), Pierik, F.H. (author)Pseudoxantoma elasticum (PXE) is a rare chromosomal disorder that results in mineralization of elastic fibers, especially in the skin, eye, and cardiovascular system. Recently, PXE has been associated with testicular microlithiasis (TM),1 which itself might be associated with testicular malignancy.2 Here we report on a 9-year-old boy with PXE...article 2008
- document
-
Walker, L.C. (author), Overstreet, M.A. (author), Siddiqui, A. (author), de Paepe, A. (author), Ceylaner, G. (author), Malfait, F. (author), Symoens, S. (author), Atsawasuwan, P. (author), Yamauchi, M. (author), Ceylaner, S. (author), Bank, R.A. (author), Yeowell, H.N. (author), TNO Preventie en Gezondheid (author)The clinical diagnosis of a patient with the phenotype of Ehlers-Danlos syndrome type VI was confirmed biochemically by the severely diminished level of lysyl hydroxylase (LH) activity in the patient's skin fibroblasts. A novel homozygous mutation, a single base change of T1360 → G in exon 13 of the LH1 gene, predicted to result in W446G, was...article 2005
- document
-
Meijboom, L.J. (author), Westerhof, B.E. (author), Nollen, G.J. (author), Spaan, J.A.E. (author), de Mol, B.A.J.M. (author), Jacobs, M.J.H.M. (author), Mulder, B.J.M. (author), TNO Biomedical Instrumentation (author)Objective: β-blocking therapy is the standard therapy in non-operated Marfan patients, however its efficacy after entire aortic replacement is unknown. The aim of this study was to describe the influence of (nearly) entire aortic replacement and β-blocking therapy on blood pressure and wave reflections in Marfan patients. Methods: Four Marfan...article 2004
- document
-
den Hartog, E.A. (author), Lotens, W.A. (author), TNO Technische Menskunde (author)In the Netherlands most murder victims are found 2-24 h after the crime. During this period, body temperature decrease is the most reliable method to estimate the postmortem time (PMT). Recently, two murder cases were analysed in which currently available methods did not provide a sufficiently reliable estimate of the PMT. In both cases a study...article 2004
- document
-
TNO Preventie en Gezondheid (author), Ha-Vinh, R. (author), Alanay, Y. (author), Bank, R.A. (author), Campos-Xavier, A.B. (author), Zankl, A. (author), Superti-Furga, A. (author), Bonafé, L. (author)Bruck syndrome (BS) is a recessively-inherited phenotypic disorder featuring the unusual combination of skeletal changes resembling osteogenesis imperfects (OI) with congenital contractures of the large joints. Clinical heterogeneity is apparent in cases reported thus far. While the genes coding for collagen 1 chains are unaffected in BS, there...article 2004
- document
-
Wensing, M. (author), Knulst, A.C. (author), Piersma, S. (author), O'Kane, F. (author), Knol, E.F. (author), Koppelman, S.J. (author)Background: Serologic cross-reactivity among legumes has been described; however, it is rarely clinically significant. In this study 3 patients with a history of anaphylaxis to pea are described who subsequently had symptoms after ingestion of peanut. Objective: We investigated whether the peanut-related symptoms were due to cross-reactivity...article 2003
- document
-
Buitendijk, S.E. (author)In the 'Overview of the role of antibiotics in curtailing labour and early delivery'(ORACLE I)-trial in women with premature rupture of membranes, the use of erythromycin was found to be associated with a decrease in the primary composite outcome (neonatal death, chronic lung disease or major cerebral abnormality on ultrasound; p = 0.08) and in...article 2001
- document
-
Anderson, D. (author), Yardley-Jones, A. (author), Hambly, R.J. (author), Vives-Bauza, C. (author), Smykatz-Kloss, V. (author), Chua-anusorn, W. (author), Webb, J. (author), TNO BIBRA International (author)Thalassaemia is a group of genetic diseases where haemoglobin synthesis is impaired. This chronic anaemia leads to increased dietary iron absorption, which develops into iron overload pathology. Treatment through regular transfusions increases oxygen capacity but also provides iron through the red cells' haemoglobin. An essential treatment, in...article 2000
- document
-
van Wouwe, J.P. (author), Dandachli, T.H. (author), Huber, J. (author), TNO Preventie en Gezondheid (author)Wiegendood is een ingrijpende gebeurtenis voor ouders en hulpverleners. Als een kind jonger dan 2 jaar plotseling levenloos wordt aangetroffen, vraagt iedereen zich af: ‘Hoe kon dit gebeuren?’ Kennis over oorzaken van wiegendood is enerzijds gebaseerd op epidemiologische analyse van de gevallen, anderzijds op bevindingen verkregen bij...article 1999
- document
-
Koppelman, S.J. (author), Wensing, M. (author), de Jong, G.A.H. (author), Knulst, A.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A new process for restructured meat and fish has been introduced to the market recently. Its main compound is casein, and it may therefore endanger patients with a milk allergy. Chemicals/CAS: Anti-Inflammatory Agents; Caseins; Lactoglobulins; Methylprednisolone, 83-43-2article 1999
- document
-
Hoffer, M.J.V. (author), Niththyananthan, S. (author), Naoumova, R.P. (author), Kibirige, M.S. (author), Frants, R.R. (author), Havekes, L.M. (author), Thompson, G.R. (author), Gaubius Instituut TNO (author)Apolipoprotein E (apoE) is one of the major protein constituents of chylomicron and very low density lipoprotein (VLDL) remnants and plays a central role as a ligand in the receptor-mediated uptake of these particles by the liver. Here we describe a new variant of apoE, apoE1-Hammersmith, which is associated with dominantly expressed type III...article 1996
- document
-
de Jong, E.C. (author), Spanhaak, S. (author), Martens, B.P.M. (author), Kapsenberg, M.L. (author), Penninks, A.H. (author), Wierenga, E.A. (author), TNO Voeding (author)Background: Increasing evidence indicates a prominent role of allergen-specific TH2 cells, with high IL-4 and IL-5 production and low interferon-γ production, in the regulation of IgE and eosinophil production in allergic disorders. However, most studies have concentrated on T cells reactive with inhalation allergens, whereas little is known...article 1996
- document
-
Baselmans, A.H.C. (author), Kuijpers, M.H.M. (author), van Dijk, J.E. (author), TNO Voeding (author)A case report is given of a very rare spontaneous mast cell tumor in the eyelid of the left eye of a female Wistar rat used in a long-term oral toxicity study. Metastasis of the tumor had occurred in the mandibular lymph nodes and in the liver. Clinically, the animal showed blepharospasm, dacryorrhoea, and exophthalmus. Hematologic findings...article 1996
Pages
- 1
- 2