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End, C. (author), Bikker, F.J. (author), Renner, M. (author), Bergmann, G. (author), Lyer, S. (author), Blaich, S. (author), Hudler, M. (author), Helmke, B. (author), Gassler, N. (author), Autschbach, F. (author), Ligtenberg, A.J.M. (author), Benner, A. (author), Holmskov, U. (author), Schirmacher, P. (author), Nieuw Amerongen, A.V. (author), Rosenstiel, P. (author), Sina, C. (author), Franke, A. (author), Hafner, M. (author), Kioschis, P. (author), Schreiber, S. (author), Poustka, A. (author), Mollenhauer, J. (author)Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial-binding spectrum. Recent functional and genetic studies linked DMBT1 to the suppression of LPS-induced TLR4-mediated NF-kappaB activation and to the pathogenesis of Crohn's disease. Here, we aimed at unraveling the molecular basis of its function...article 2009
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de Wijk, R.A. (author), van Gemert, L.J. (author), Terpstra, M.E.J. (author), Wilkinson, C.L. (author), TNO Voeding (author)A trained panel developed a set of sensory attributes describing flavor, odor, mouth feel and after feel sensations elicited by commercially available vanilla custard desserts. Two main sensory dimensions, one running from "melting" to "thick" and another one running from "rough" to "creamy-soft" could be recognized in the resulting sensory...article 2003
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van de Velde, F. (author), Rollema, H.S. (author), Grinberg, N.V. (author), Burova, T.V. (author), Grinberg, V.Ya. (author), Hans Tromp, R. (author), TNO Voeding (author)A series of ι-carrageenans containing different amounts of v-carrageenan (0-23 monomer %) have been prepared from neutrally extracted carrageenan of Eucheuma denticulatum. v-Carrageenan is the biochemical precursor of ι-carrageenan. The conformational order-disorder transition and rheological properties of these carrageenans were studied using...article 2002
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van de Velde, F. (author), Peppelman, H.A. (author), Rollema, H.S. (author), Tromp, R.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The coil-to-helix transition and temperature dependence of the viscosity of commercial κ/ι-hybrid carrageenans produced by the red algae Sarcothalia crispata, Mazaella laminarioides, and Chondrus crispus were studied using rheometry and optical rotation. The structure of these κ/ι-hybrid carrageenans was determined by 1H and 13C NMR spectroscopy...article 2001
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Radiobiologisch Instituut TNO (author), Maat, B. (author)Warfarin administered to tumor-bearing mice reduces the number of spontaneous lung metastases. Both macrophage inhibitors silica and carrageenan abolish the warfarin-induced decrease in tumour metastasis, which strongly supports the concept that the antitumour effect of coumarin derivatives is mediated by stimulation of macrophages. The results...article 1980