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Bots, M.L. (author), van der Bom, J.G. (author), Haverkate, F. (author), Meijer, P. (author), Hofman, A. (author), Grobbee, D.E. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)Background and objective. A low activated protein C (APC) response increases the risk of venous thrombosis, and possibly arterial disease. Apart from the factor V Leiden mutation, other factors may determine the level of APC response. In most studies on the association with arterial disease, cardiovascular risk factors were not appropriately...article 1996
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van Poppel, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective and conclusions: This article gives an overview of observational and experimental epidemiological studies relating β-carotene to risk of cancer and cardiovascular disease. Observational epidemiological studies have consistently shown that a diet rich in β-carotenerich fruits and vegetables or high blood levels of β-carotene are...article 1996
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van de Vijver, L.P.L. (author), Steyger, R. (author), van Poppel, G. (author), Boer, J.M.A. (author), Kruijssen, D.A.C.M. (author), Seidell, J.C. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)Autoantibodies against oxidized low-density lipoprotein (LDL) have been reported to be associated with atherosclerosis. However, data are not consistent. We compared the titres of autoantibodies to malondialdehyde-modified LDL in three groups, a case group with angiographically documented severe coronary stenosis (> 80% stenosis in at least 1...article 1996
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Virtanen, S.M. (author), van 't Veer, P. (author), Kok, F. (author), Kardinaal, A.F.M. (author), Aro, A. (author)The adipose tissue carotenoid (alpha-carotene, beta-carotene, and lycopene) and retinol levels and their predictors were determined in 686 male and 339 female middle-aged and elderly subjects from eight European countries and Israel during the years 1991 to 1992. Adipose tissue carotenoid levels in men were 50-76% of those in women, whereas the...article 1996
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- Kluft, C. (author), Gaubius (author) article 1996
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te Velthuis- Wierik, E.J.M. (author), van den Berg, H. (author), Weststrate, J.A. (author), van het Hof, K.H. (author), de Graaf, C. (author), TNO Voeding (author)Objective: Dietary fat intake is higher than recommended in most western countries and is associated with the prevalence of cardiovascular diseases, obesity and cancer. The growing public concern about the adverse effects of a high fat intake has led to an increased availability of 'reduced-fat' products. Consumption of reduced-fat products...article 1996
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Heijmans, B.T. (author), Kluft, C. (author), Bots, M.L. (author), Lagaay, A.M. (author), Brand, A. (author), Grobbee, D.E. (author), Knook, D.L. (author), Slagboom, P.E. (author), Gaubius Instituut TNO (author)The genetic component of human longevity is estimated at 30%. Which genes are involved in determining human longevity, however, is largely unknown. Genes that may affect human survival are susceptibility loci for major age related pathologies. Many studies are being performed to identify such loci for cardiovascular disease, dementia and...article 1996
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de Maat, M.P.M. (author), de Knijff, P. (author), Green, F.R. (author), Thomas, A.E. (author), Jespersen, J. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)Elevated plasma fibrinogen levels represent an increased risk for cardiovascular diseased, but the mechanism explaining this association is still not clear. Genetic differences may play a role, because it has been shown that individuals who carry the rare alleles of polymorphisms in the genes for the Bβ-chain (Bcl I and G/A 455) and the Aα-chain...article 1995
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Grootenhuis, P.A. (author), Westenbrink, S. (author), Sie, C.M.T.L. (author), de Neeling, J.N.D. (author), Kok, F.J. (author), Bouter, L.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A self-administered semiquantitative food frequency questionnaire including 75 food items and providing information on the habitual intake of 31 nutritional parameters, based on the intake of protein, fat, carbohydrate, fiber and 11 vitamins and minerals, was developed for use in epidemiologic research on chronic disease among the elderly, such...article 1995
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Havenith, G. (author), Inoue, Y. (author), Luttikholt, V. (author), Kenny, W.L. (author)Cross-section comparisons of the effect of age on physiological responses to heat stress have yielded conflicting results, in part because of the inability to separate chronological age from factors which change in concert with the biological aging process. The present study was designed to examine the relative influence of age on cardiovascular...article 1995
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Nieuwenhuizen, W. (author), TNO Preventie en Gezondheid (author)Fibrinogen is a large heterogeneous family of closely related molecules consisting of three pairs of non-identical polypeptide chains: two Aα-, two Bβ- and two γ-chains, held together by disulphide bridges. The heterogeneity of fibrinogen is due to heterogeneities in all three chains. Four main types of assay are used to determine fibrinogen...article 1995
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van Poppel, G. (author), Hospers, J. (author), Nieuwenhuizen, W. (author), Laterveer, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A high intake of β-carotene has been associated with a decreased risk for cardiovascular disease. To evaluate whether β-carotene may exert a protective effect through an impact on haemostasis a randomized, placebo-controlled trial was conducted in male smokers (n = 149) using 20 mg/day β-carotene for 14 weeks. For comparisons, haemostatic...article 1995
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Gevers Leuven, J.A. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)Lipoprotein metabolism is involved in atherogenesis. Female sex-hormones have substantial effects on both lipoprotein metabolism and the vessel wall. Cholesterol, one of the major lipids in lipoproteins, is both the substrate for, and the target of, the steroidal sex hormones.article 1994
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Kluft, C. (author), TNO Preventie en Gezondheid (author)In the population at large and in individual normal volunteers, baseline molar concentratios of t-PA and PAI-1 in plasma show a strong correlation. Evidence is summarized that insulin resistance is a prominent cause of interindividual variation, next to possible contributions of vascular inflammation and steroid hormones. In healthy volunteers,...article 1994
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Dooijewaard, G. (author), van Boheemen, P.A. (author), Binnema, D.J. (author), Kluft, C. (author), Gaubius Laboratory, VVO-TNO, PO Box 430, 2300 AK Leiden, Instituut voor verouderings- en vaatziekten onderzoek TNO (author)Chemicals/CAS: Tissue Plasminogen Activator, EC 3.4.21.68; Urinary Plasminogen Activator, EC 3.4.21.73article 1992
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Schaapveld, K. (author), van de Water, H.P.A. (author), Bergsma, E.W. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)In the last few years prevention has again become the focus of attention because of various international developments such as the WHO strategy for Health for All by the year 2000. When resources are scarce, it is all the more important to set priorities. This applies to prevention as well as to curative care. In this paper, we describe a method...article 1992
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Gaubius Instituut TNO (author), van Hinsbergh, V.W.M. (author)Chemicals/CAS: Cytokines; Plasminogen Activator Inhibitor 1; plasminogen activator, urokinase receptors; Plasminogen, 9001-91-6; Receptors, Cell Surface; Urinary Plasminogen Activator, EC 3.4.21.73.article 1992
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van Lieshout, J.J. (author), Wieling, W. (author), Settels, J.J. (author), Karemaker, J.M. (author), TNO Biomedical Instrumentation (author)In a patient with tetanus we tested the hypothesis that the hyperadrenergic cardiovascular instability might be due to impairment of the baroreceptor reflex by the tetanus toxin. Baroreflex sensitivity assessed with the phenylephrine method was found to be normal. Changes in arterial pressure correlated inversely with relative changes in plasma...article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Poppel, G.van. (author), Schneijder, P. (author), Löwik, M.R.H. (author), Schrijver, J. (author), Kok, F.J. (author)As part of the Dutch Nutrition Surveillance System, cardiovascular risk factors and food consumption (24 h recall) as well as haematological, Fe and vitamin status (A, B6, C) were assessed in 126 Dutch boys aged 10-11 years (response 71%). Body mass index (BMI) and the sum of four skinfolds were strongly associated (r 0.85, P < 0.01) and 8% of...article 1991
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Lowik, M.R.H. (author), Schrijver, J. (author), Odink, J. (author), van den Berg, H. (author), Wedel, M. (author), Hermus, R.J.J. (author), TNO Kwaliteit van Leven (author)In a nationwide survey the nutritional status was assessed of 539 apparently healthy, independently living elderly aged 65-79 years. Anthropometric data showed no energy deficits. The prevalence of anemia was 4 and 1% among men and women, respectively. Many elderly showed a low level of 25-hydroxyvitamin D in plasma (< 31 nmol/L: men 35%; women...article 1990