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Carracedo, M. (author), Pawelzik, S.C. (author), Artiach, G. (author), Pouwer, M.G. (author), Plunde, O. (author), Saliba-Gustafson, P. (author), Ehrenborg, E. (author), Eriksson, P. (author), Pieterman, E. (author), Stenke, L. (author), Princen, H.M.G. (author), Franco-Cereceda, A. (author), Bäck, M. (author)Background and purpose: Tyrosine kinase inhibitors (TKI) used to treat chronic myeloid leukemia (CML) have been associated with cardiovascular side effects, including reports on calcific aortic valve stenosis. The aim of this study was to establish the effects of first and second generation TKIs in aortic valve stenosis, and to determine the...article 2022
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Lee, S.W.S. (author), Millet, K. (author), Grinstein, A. (author), Pauwels, K.H. (author), Johnston, P.R. (author), Volkov, A.E. (author), van der Wal, A.J. (author)The human mind harbors various mechanisms for coping with stress, but what role does physical behavior play? Inspired by ethological observations of autogrooming activity across species, we offer a general hypothesis: cleaning attenuates effects of stressful events. Preregistered behavioral and psychophysiological experiments (N = 3,066 in...article 2022
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Suchowerska, A.K. (author), Stokman, G. (author), Palmer, J.T. (author), Coghlan, P.A. (author), Pieterman, E.J. (author), Keijzer, N. (author), Lambert, G. (author), Chemello, K. (author), Jaafar, A.K. (author), Parmar, J. (author), Yan, L. (author), Tong, Y. (author), Mu, L. (author), Princen, H.M.G. (author), Bonnar, J. (author), Evison, B.J. (author)Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibits the clearance of low-density lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly binding with the LDL receptor (LDLR) and sending the receptor for lysosomal degradation. As the interaction promotes elevated plasma LDL-C levels, and therefore a predisposition to...article 2022
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van Lier, H.G. (author), Noordzij, M.L. (author), Pieterse, M.E. (author), Postel, M.G. (author), Vollenbroek-Hutten, M.M.R. (author), de Haan, H.A. (author), Schraagen, J.M.C. (author)Introduction: Alcohol craving is a highly challenging obstacle to achieve long-term abstinence. Making alcohol use disorder patients timely aware of high-risk craving situations may protect them against relapse by prompting them to mobilize their coping resources. Current advances in wearable and smart-phone technology provide novel...article 2022
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Zwingmann, K. (author), Hüber, L. (author), Verwey, W.B. (author), Barnhoorn, J.S. (author), Godde, B. (author), Voelsker-Rehage, C. (author)Introduction: Older adults show higher interindividual performance variability during the learning of new motor sequences than younger adults. It is largely unknown what factors contribute to this variability. This study aimed to, first, characterize age differences in motor sequence learning and, second, examine influencing factors for...article 2021
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- Zwingmann, K. (author), Hüber, L. (author), Verwey, W.B. (author), Barnhoorn, J.S. (author), Godde, B. (author), Voelsker-Rehage, C. (author) article 2021
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Simons, R. (author), Maire, R. (author), van Drongelen, A. (author), Valk, P. (author)BACKGROUND: This article presents the results of an EASA-commissioned study aimed at analyzing the medical causes of grounding of a broad European pilot population and recommending measures to reduce the risk of in-flight incapacitation in commercial air transport pilots. METHOD: European National Aviation Authorities (NAAs) were requested to...article 2021
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van Keulen, D. (author), van Koeverden, I.D. (author), Boltjes, A. (author), Princen, H.M.G. (author), van Gool, A.J. (author), de Borst, G.J. (author), Asselbergs, F.W. (author), Tempel, D. (author), Pasterkamp, G. (author), van der Laan, S.W. (author)Background and Aims: Oncostatin M (OSM) signaling is implicated in atherosclerosis, however the mechanism remains unclear. We investigated the impact of common genetic variants in OSM and its receptors, OSMR and LIFR, on overall plaque vulnerability, plaque phenotype, intraplaque OSMR and LIFR expression, coronary artery calcification burden and...article 2021
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Simons, R. (author), Maire, R. (author)Recommendations. It is recommended that all aircrew, especially those over the age of 40 years, should be periodically screened for cardiovascular risk using a resting ECG and risk estimating calculators that are representative and appropriate for the population to screen and provide non-fatal and fatal endpoints. Pilots with an elevated CVD...article 2020
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Pouwer, M.G. (author), Pieterman, E.J. (author), Worms, N. (author), Keijzer, N. (author), Jukema, J.W. (author), Gromada, J. (author), Gusarova, V. (author), Princen, H.M.G. (author)Atherosclerosis-related cardiovascular disease causes nearly 20 million deaths annually. Most patients are treated after plaques develop, so therapies must regress existing lesions. Current therapies reduce plaque volume, but targeting all apoB-containing lipoproteins with intensive combinations that include alirocumab or evinacumab-monoclonal...article 2020
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Pouwer, M.G. (author)The thesis discussed several strategies that may contribute to further CVD risk reduction in the future. We described two novel lipid-lowering strategies, we unraveled (part of) the etiology of the cardiovascular safety issues of TKIs that are used for the treatment of CML, and we investigated the dose effects of PFOA on lipoprotein metabolism....doctoral thesis 2020
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Dopsa, D.D. (author), Kronemeijer, A.J. (author), Gelinck, G. (author)Integrating electronics with organ-on-chip-related technologies can assist in the development of better medicines, such as those for neurodegenerative and cardiovascular diseases. Holst Centre looks to contribute its flexible electronics and manufacturing expertise to the ecosystem. The early publication: The 3 dimensions of Organ-on-a-chip,...other 2020
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Kallen, V. (author), Marck, J.W. (author), Stam, J. (author), Issa, A. (author), Johnson, B. (author), van Meeteren, N. (author)The steadily growing elderly population calls for efficient, reliable and preferably ambulant health supervision. Since cardiovascular risk factors interact with psychosocial strain (e.g., depression), we investigated the potential contribution of psychosocial factors in discriminating generally healthy elderly from those with a cardiovascular...article 2020
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van Ginneken, V. (author), Verheij, E.R. (author), de Vries, E. (author), Schouten, F. (author), van der Greef, J. (author)There are currently two main directions with regard to nutritional supplements with PUFAs. The first research school recommends enriching the diet with the essential fatty acid (EFA) obtained from vegetable sources, the C18 lipid omega-3 molecule α-linolenic acid and then via the elongase/desaturase activity naturally in omega-3 Eicosapentaenoic...article 2020
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Schuster, S. (author), Rubil, S. (author), Endres, M. (author), Princen, H.M.G. (author), Boeckel, J.N. (author), Winter, K. (author), Werner, C. (author), Laufs, U. (author)LDL-cholesterol (LDL-C) is a causal pathogenic factor in atherosclerosis. Monoclonal anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) neutralizing antibodies are novel potent LDL-lowering drugs which reduce cardiovascular events. To characterize their effect on atherogenesis, APOE*3Leiden.CETP mice were fed a high cholesterol/high fat...article 2019
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van Keulen, D. (author)Despite the increase in knowledge about cardiovascular diseases and the increase in available drugs since the beginning of the 20th century, one out of three people still dies from cardiovascular diseases. In more than 50% of all cases, atherosclerosis is the underlying pathology and therefore, it is of great importance to develop better...doctoral thesis 2019
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Kingma, B.R.M. (author), Folkerts, M. (author), Klous, L. (author), Catoire, C.M. (author), van Schaik, S.M.G. (author)Introduction Exercise in a warm environment is typically correlated with a higher heart rate (HR) than the same exercise in a cool environment. In literature this effect is explained by the increased cardiac output (CO) due to increased skin blood flow, complemented with reductions in stroke volume (SV) due to venous pooling and dehydration....conference paper 2018
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Kuijpers, E. (author), Pronk, A. (author), Kleemann, R. (author), Vlaanderen, J. (author), Lan, Q. (author), Rothman, N. (author), Silverman, D. (author), Hoet, P. (author), Vermeulen, R. (author)Objectives: The increase in production of multiwalled carbon nanotubes (MWCNTs) has led to growing concerns about health risks. In this study, we assessed the association between occupational exposure to MWCNTs and cardiovascular biomarkers. Methods: A cross-sectional study was performed among 22 workers of a company commercially producing...article 2018
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Tsikas, D. (author), Pham, V.V. (author), Suchy, M.T. (author), van de Ree, M.A. (author), Huisman, M.V. (author), Frölich, J.C. (author), Princen, H.M.G. (author)The present study describes the effects of atorvastatin on whole body synthesis of nitric oxide (NO), prostacyclin (PGI2), and thromboxane A2 (TxA2), on oxidative stress and nitrite/nitrate-related renal carbonic anhydrase (CA) activity in patients with type 2 diabetes mellitus (T2DM). A double-blind, randomized, placebo-controlled parallel...article 2015
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Kivimäki, M. (author), Jokela, M. (author), Nyberg, S.T. (author), Singh-Manoux, A. (author), Fransson, E.I. (author), Alfredsson, L. (author), Bjorner, J.B. (author), Borritz, M. (author), Burr, H. (author), Casini, A. (author), Clays, E. (author), de Bacquer, D. (author), Dragano, N. (author), Erbel, R. (author), Geuskens, G.A. (author), Hamer, M. (author), Hooftman, W.E. (author), Houtman, I.L. (author), Jöckel, K.H. (author), Kittel, F. (author), Knutsson, A. (author), Koskenvuo, M. (author), Lunau, T. (author), Madsen, I.E. (author), Nielsen, M.L. (author), Nordin, M. (author), Oksanen, T. (author), Pejtersen, J.H. (author), Pentti, J. (author), Rugulies, R. (author), Salo, P. (author), Shipley, M.J. (author), Siegrist, J. (author), Steptoe, A. (author), Suominen, S.B. (author), Theorell, T. (author), Vahtera, J. (author), Westerholm, P.J.M. (author), O'Reilly, D. (author), Kumari, M. (author), Batty, G.D. (author), Ferrie, J.E. (author), Virtanen, M. (author)Background: Long working hours might increase the risk of cardiovascular disease, but prospective evidence is scarce, imprecise, and mostly limited to coronary heart disease. We aimed to assess long working hours as a risk factor for incident coronary heart disease and stroke. Methods: We identified published studies through a systematic review...article 2015