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Dommels, Y.E.M. (author), Heemskerk, S. (author), van den Berg, H. (author), Alink, G.M. (author), van Bladeren, P.J. (author), van Ommen, B. (author)Modulating effects of high fat fish oil (HFFO) and high fat corn oil (HFCO) diets on azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) were studied in male F344 rats following 8 weeks of dietary treatment. The incidence of AOM-induced ACF was significantly lower in the proximal colon of rats fed the HFFO diets compared with rats fed...article 2003
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Broekmans, W.M.R. (author), Vink, A.A. (author), Boelsma, E. (author), Klöpping-Ketelaars, W.A.A. (author), Tijburg, L.B.M. (author), van 't Veer, P. (author), van Poppel, G. (author), Kardinaal, A.F.M. (author), TNO Voeding (author)Background: Acute effects of UV irradiation include UV-induced erythema. Sunlight plays an important role in the development of skin cancer. Several predictive factors of UV-induced erythema could also be predictive for skin cancer. Objective: Our objective was to quantitatively assess phenotypical and nutritional determinants of sensitivity to...article 2003
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Rhodes, L.E. (author), Shahbakhti, H. (author), Azurdia, R.M. (author), Moison, R.M.W. (author), Steenwinkel, M.J.S.T. (author), Homburg, M.I. (author), Dean, M.P. (author), McArdle, F. (author), Beijersbergen van Henegouwen, G.M.J. (author), Epe, B. (author), Vink, A.A. (author)Dietary omega-3 polyunsaturated fatty acids (ω-3 PUFAs) protect against photocarcinogenesis in animals, but prospective human studies are scarce. The mechanism(s) underlying the photoprotection are uncertain, although ω-3 PUFAs may influence oxidative stress. We examined the effect of supplementation on a range of indicators of ultraviolet...article 2003
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van Engeland, M. (author), Weijenberg, M.P. (author), Roemen, G.M.J.M. (author), Brink, M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Baylin, S.B. (author), de Goeij, A.F.P.M. (author), Herman, J.G. (author)Sporadic colorectal cancer (CRC) is characterized by genetic and epigenetic changes such as regional DNA hypermethylation and global DNA hypomethylation. Epidemiological and animal studies suggest that aherrant DNA methylation is associated with low dietary folate intake, which is aggravated by high alcohol intake. The relationship between...article 2003
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Hambly, R.J. (author), Saunders, M. (author), Rijken, P.J. (author), Rowland, I.R. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Although there is much epidemiological evidence for an interaction between diet and colorectal cancer risk, the mechanisms by which diet might protect against colorectal cancer are still unclear. Here we report the significant up-regulation of carcinogen-induced apoptosis in the colon of rats fed a diet containing low-risk factors for colon...article 2002
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Dommels, Y.E.M. (author), Alink, G.M. (author), van Bladeren, P.J. (author), van Ommen, B. (author), TNO Voeding (author)During the past few decades, many studies have been conducted to evaluate the effects of n-6 and n-3 polyunsaturated fatty acids (PUFAs) on colorectal carcinogenesis. This report provides a brief overview of the recent studies that have been performed in cultured colon cells, animal models as well as of the population-based and short-term...article 2002
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Anderson, D. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO BIBRA (author)Butadiene (BD) and its 2-methyl analogue, isoprene, have been extensively studied in animals and BD in population studies. Both chemicals are metabolised by liver cytochrome P450 dependent monogenases to monoepoxide and diepoxide intermediates. The diepoxide intermediates of both compounds were mutagenic in Salmonella typhimurium. However,...article 2001
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Feron, V.J. (author), Arts, J.H.E. (author), Kuper, C.F. (author), Slootweg, P.J. (author), Woutersen, R.A. (author)Health risks of inhaled nasal toxicants were reviewed with emphasis on chemically induced nasal lesions in humans, sensory irritation, olfactory and trigeminal nerve toxicity, nasal immunopathology and carcinogenesis, nasal responses to chemical mixtures, in vitro models, and nasal dosimetry- and metabolism-based extrapolation of nasal data in...article 2001
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Hooser, S.T. (author), van Dijk-Knijnenburg, C.M. (author), Waalkens-Berendsen, I.D.H. (author), Smits-van Prooije, A.E. (author), Snoeij, N.J. (author), Baan, R.A. (author), Fichtinger-Schepman, M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Exposure of males to some genotoxic chemicals causes DNA damage in spermatozoa resulting in embryotoxicity and developmental defects in their offspring. This study demonstrates that cisplatin-DNA adducts could be measured in spermatozoa following treatment with the antineoplastic drug, cisplatin. The formation of spermatozoa cisplatin-DNA...article 2000
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Graaf, I.A.M. (author), Tajima, O. (author), Groten, J.P. (author), Wolterbeek, A.P.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Gap junctional intercellular communication (GJIC) and cell proliferation were studied in control and 1,1'-bis(p-chlorophenyl)-2,2,2,-trichloroethane (DDT) treated precision-cut liver slices of rat by evaluating connexin 32 (Cx32) expression and 5-bromo-2'-deoxyuridine (BrdU) incorporation. In addition, the effect of different culture media (RPMI...article 2000
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Emri, G. (author), Wenczl, E. (author), van Erp, P. (author), Jans, J. (author), Roza, L. (author), Horkay, I. (author), Schothorst, A.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Chromosomal defects are frequently present in malignant and premalignant skin disorders; however, it is not known whether ultraviolet radiation from sunlight plays a role in their induction. To obtain information on the ability of ultraviolet A and ultraviolet B to induce chromosomal aberrations, cultured melanocytes and fibroblasts were exposed...article 2000
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van Iersel, M.L.P.S. (author), Verhagen, H. (author), van Bladeren, P.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The fact that dietary compounds influence the susceptibility of human beings to cancer, is widely accepted. One of the possible mechanisms that is responsible for these (anti)carcinogenic effects is that dietary constituents may modulate biotransformation enzymes, thereby affecting the (anti)carcinogenic potential of other compounds. This...article 1999
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Woutersen, R.A. (author), Appel, M.J. (author), Garderen van -Hoetmer, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Previously performed short-term (4-month) studies demonstrated that vitamins C and E, β-carotene and selenium modulate growth of early putative preneoplastic acinar lesions induced in rat pancreas by azaserine. The present paper summarizes the results of long-term studies performed with azaserine-treated rats maintained on diets high in either β...article 1999
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Kirev, T. (author), Woutersen, R.A. (author), Kiril, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The effects of a diet enriched with 25% raw soya bean flour (RSF) on the pancreas and on the avian retrovirus Pts 56-induced pancreatic carcinogenesis in guinea fowl were studied. It has been shown that prolonged RSF feeding of new-hatched virus-infected and uninfected guinea fowl-poults induced enlargement of the pancreas, which was less...article 1999
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Lina, B.A.R. (author), van Garderen-Hoetmer, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Systemic alkalosis has been postulated to enhance tumorigenesis, whereas systemic acidosis has been implicated to exert a favourable influence on tumour control and regression. In the present study the urinary pH was influenced by feeding acid-forming or base-forming diets, and the effect of alkaline or acid urine on the early and late...article 1999
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), van Loo, J. (author), Cummings, J. (author), Delzenne, N. (author), Englyst, H. (author), Franck, A. (author), Hopkins, M. (author), Kok, N. (author), Macfarlane, G. (author), Newton, D. (author), Quigley, M. (author), Roberfroid, M. (author), van Vliet, T. (author), van den Heuvel, E. (author)This paper results from the final phase of the ENDO project (DGXII AIRII-CT94-1095), a European Commission-funded project on non-digestible oligosaccharides (NDO). All participants in the programme met to perform a consensus exercise on the possible functional food properties of NDO. Topics studied during the project (including a workshop on...article 1999
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Rijnkels, J.M. (author), Hollanders, V.M.H. (author), Woutersen, R.A. (author), Koeman, J.H. (author), Alink, G.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The potential inhibitory effects of a vegetables-fruit mixture on the initiation and promotion phases of azoxymethane-induced colorectal carcinogenesis were examined in rats fed low- or high-fat diets. Rats were fed low-fat diets (20 energy percent, Diets A and B) or high-fat diets (40 energy percent, Diets C and D), supplemented with a...article 1998
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Souliotis, V.L. (author), van Delft, J.H.M. (author), Steenwinkel, M.-J.S.T. (author), Baan, R.A. (author), Kyrtopoulos, S.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Groups of λlacZ transgenic mice were treated i.p. with N-nitrosodimethylamine (NDMA) as single doses of 5 mg/kg or 10 mg/kg or as 10 daily doses of 1 mg/kg and changes in DNA N7- or O6-methylguanine or the repair enzyme O6-alkylguanine-DNA alkyltransferase (AGT) were followed for up to 14 days in various tissues. Adduct induction in the liver...article 1998
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Simonsen, N. (author), van 't Veer, P. (author), Strain, J.J. (author), Martin-Moreno, J.M. (author), Huttunen, J.K. (author), Navajas, J.F.-C. (author), Martin, B.C. (author), Thamm, M. (author), Kardinaal, A.F.M. (author), Kok, F.J. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The fatty acid content of adipose tissue in postmenopausal breast cancer cases and controls from five European countries in the European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Cancer (EURAMIC) breast cancer study (1991-1992) was used to explore the hypothesis that fatty acids of the omega-3 family inhibit breast...article 1998
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van Poppel, G. (author), van den Berg, H. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)The prospect that high intake of certain vitamins may confer protection against cancer has drawn substantial attention during the last decades. This paper gives a concise update of the role of a number of promising vitamins in prevention of cancer. Vitamin A and its analogues have an important role in cellular processes related to carcinogenesis...article 1997