A novel safety assessment strategy applied to non-selective extracts

A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult...

A novel safety assessment strategy for non-intentionally added substances (NIAS) in carton food contact materials

One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess...

Improving the scratch resistance of sol-gel metal oxide coatings cured at 250 C through use of thermogenerated amines

Scratch resistant sol-gel metal oxide coatings typically require a thermal post-treatment step (curing process) at temperatures between 400 and 700 C. In this report, we demonstrate that the in situ generation of amines within sol-gel films facilitates the preparation of scratch resistant metal oxide coatings at a curing temperature of 250 C. A...

Toxicokinetics of the nerve agent (±)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration

In continuation of our investigations on the toxicokinetics of the volatile nerve agents C(±)P(±)-soman and (±)-sarin, we now report on the toxicokinetics of the rather nonvolatile agent (±)-VX. A validated method was developed to determine blood levels of (±)-VX by means of achiral gas chromatography at blood levels ≥10 pg/ml. The ratio of the...

Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase

Effects of commonly used carbamate pesticides on rat neuronal nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes have been investigated using the two-electrode voltage clamp technique. The potencies of these effects have been compared to the potencies of the carbamates to inhibit rat brain acetylcholinesterase. The potency...

Effects of low doses of cholinesterase inhibitors on behavioral performance of robot-tested marmosets

To investigate at which dose levels undesirable effects started, behavioural performance and several physiological parameters were measured in marmosets (Callithrix Jacchus) after soman (1.75 and 3.5 μg/kg), sarin (3 and 6 μg/kg), physostigmine (10 and 20 μg/kg), and pyridostigmine (200 and 400 μg/kg). Effects on performance were investigated...

Assessment of dermal and inhalation exposure to zineb/maneb in the cultivation of flower bulbs

In bulb farming the use of pesticides for crop protection and bulb disinfection is extensive. To estimate long-term occupational exposure to pesticides, generic levels of exposure specific to the method of working were needed. In order to derive these values, dermal and inhalation exposure was the fungicide mixture zineb/maneb was assessed for...

Determination of ethyl carbamate in alcoholic beverages by two-dimensional gas chromatography

Differential binding of methyl benzimidazol 2 yl carbamate to fungal tubulin as a mechanism of resistance to this antimiotic agent in mutant strains of Aspergillus nidulans

Chemicals/CAS: benomyl, 17804-35-2; carbon 14, 14762-75-5; colchicine, 64-86-8; fuberidazole, 3878-19-1; griseofulvin, 126-07-8; mebendazole, 31431-39-7; melatonin, 73-31-4; nocodazole, 31430-18-9; parbendazole, 14255-87-9; podophyllotoxin, 518-28-5; tiabendazole, 148-79-8; vinblastine, 865-21-4; Benzimidazoles; Carbamates; Colchicine, 64-86-8;...