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Marijnissen, A.C.A. (author), van Roermund, P.M. (author), TeKoppele, J.M. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TNO Preventie en Gezondheid (author)Objective: The frequently used anterior cruciate ligament transection (ACLT) model of osteoarthritis (OA) in the dog, makes use of a permanent trigger (joint instability) for inducing degenerative changes. The present study evaluates a canine model of degenerative cartilage damage, mimicking OA, which is induced without making use of permanent...article 2002
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Marijnissen, A.C.A. (author), van Roermund, P.M. (author), Verzijl, N. (author), Tekoppele, J.M. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TNO Preventie en Gezondheid (author)Objective: Recently we described a canine model of osteoarthritis (OA), the groove model with features of OA at 10 weeks after induction, identical to those seen in the canine anterior cruciate ligament transection (ACLT) model. This new model depends on cartilage damage accompanied by transient intensified loading of the affected joint. The...article 2002