Searched for: subject%3A%22Cancer%22
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de Bruin, P.A.F. (author), Griffioen, G. (author), Verspaget, H.W. (author), Verhijend, J.H. (author), Dooijewaard, G. (author), van den Ingh, H.F. (author), Lamers, B.H.W. (author), Gezondheidsorganisatie TNO Gaubius instituut TNO (author)
Plasminoceli activator (PA) activity, in particular urokinase (u-PA), has been shown to be markedly increased in adenocarcinomas of the colon. Adenomatous polyps were found to be intermediate in their PA activity to normal mucosa and adenocarcinomas. In the present study we evaluated the PA profile in relation to malignancy parameters of the...
article 1988
document
Instituut voor Experimentele Gerontologie TNO (author), Croese, J.W. (author), Vas Nunes, C.M. (author), Radl, J. (author), Enden-Vieveen, M.H.M. (author), van den Brondijk, R.J. (author), Boersma, W.J.A. (author)
The transplantable C57BL/KaLwRij mouse 5T2 multiple myeloma (MM) is a new animal model for studies on MM in man. Histological examination of the 5T2 MM cells revealed their morphological heterogeneity. In this study we investigated whether this heterogeneity reflects subpopulations of 5T2 MM cells with different biological properties. 5T2 MM...
article 1987
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Instituut CIVO-Toxicologie en voeding TNO (author), Woutersen, R.A. (author), Appelman, L.M. (author), van Garderen-Hoetmer, A. (author), Feron, V.J. (author)
Male and female Wistar rats were exposed to acetaldehyde vapour at nominal concentrations 0, 750, 1500 or 3000/1000 ppm during 6 h/day, 5 days/week for up to 28 months. Major compound-related effects included increased mortality, growth retardation, nasal tumours, and non-neoplastic nasal changes in each of the test groups. The treatment-related...
article 1986
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Instituut CIVO-Toxicologie en voeding TNO (author), Kroes, R. (author), Beems, R.B. (author), Bosland, M.C. (author), Bunnik, G.S.J. (author), Sinkeldam, E.J. (author)
Dietary factors are now considered to be among the most important environmental risk determinations for cancer. In addition to epidemiological studies, experimental animal studies are an important tool to investigate dietary modulation in carcinogenesis. Results of recent experimental studies on the effect of some nutrients indicate that vitamin...
conference paper 1986
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Reynders, J.B.J. (author), Immel, H.R. (author), Scherrenberg, P.M. (author), Feron, V.J. (author), Beems, R.B. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Two groups of male and female Syrian golden hamsters, of which the trachea was severely injured by electrocoagulation, received 6 weekly intratracheal instillations of benzo[a]pyrene (BaP) + ferric oxide in saline or saline alone. Two comparable groups of hamsters were similarly treated but had an undamaged trachea. The experiment was terminated...
article 1985
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Schreurs, W.H.P. (author), Odink, J. (author), Egger, R.J. (author), Wedel, M. (author), Bruning, P.F. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Chemicals/CAS: Ascorbic Acid, 50-81-7; Calcifediol, 19356-17-3; Vitamin A, 11103-57-4; Vitamin B 12, 68-19-9; Vitamin E, 1406-18-4; Vitamins
article 1985
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Woutersen, R.A. (author), Appelman, L.M. (author), Feron, V.J. (author), van der Heijden, C.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Male and female Wistar rats were exposed to acetaldehyde vapour at concentrations of 0, 750, 1500 and 3000/1000 ppm during 6 h/day, 5 days/week for up to 27 months. The present paper deals with the results obtained during the first 15 months of the study, including interim kills after 13, 26 and 52 weeks. Major compound-related lesions occurred...
article 1984
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Centraal Instituut voor Voedingsonderzoek TNO (author), Beems, R.B. (author), van Beek, L. (author)
Chemicals/CAS: benzo[a]pyrene, 50-32-8; Benzo(a)pyrene, 50-32-8; Benzopyrenes; Carcinogens; Dietary Fats; Fatty Acids, Unsaturated.
article 1984
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Bosland, M.C. (author), Prinsen, M.K. (author), Kroes, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Prostatic adenocarcinomas were induced in 5 out of 20 Wistar rats upon a single administration of 50 mg/kg N-nitroso-N-methylurea (NMU). The rats were pretreated with a daily dose of 50 mg/kg cyproterone acetate for 3 weeks followed by 3 daily injections of 100 mg/kg testosterone. All tumours developed in the dorsolateral prostate and were...
article 1983
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Reuzel, P.G.J. (author), Feron, V.J. (author), Spit, B.J. (author), Beems, R.B. (author), Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Cofactors involved in respiratory tract carcinogenesis were studied in Syrian golden hamster or in rats using benzo(a)pyrene as the carcinogenic agent. These factors included severe tissue tissue damage induced by electro-coagulation, glass fibers administered by intratracheal instillation, acetaldehyde as irritant vapor, food restriction, and...
article 1983
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Instituut CIVO-Toxicologie en voeding TNO (author), van Dokkum, W. (author), de Boer, B.C.J. (author), van Faassen, A. (author), Pikaar, N.A. (author), Hermus, R.J.J. (author)
We suggest that a lower faecal pH may be correlated with a lower mortality of large-bowel cancer and that faecal pH should always be considered in epidemiological studies on the role of diet in colon carcinogenesis.
article 1983
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Spit, B.J. (author), Feron, V.J. (author), Hendriksen, C.F.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The hepatic angiosarcoma studied was from a male Wistar rat having been exposed to vinyl chloride monomer (VCM) by the oral route for 120 weeks. Widened sinusoids lined by large electron-lucent, spindle-shaped tumor cells and membrane-bound nuclear-free structures were seen in the transitional zone between the tumor mass and the adjacent liver...
article 1981
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Feron, V.J. (author), van den Heuvel, P.D. (author), Koeter, H.B.W.M. (author), Beems, R.B. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1980
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Radiobiologisch Instituut TNO (author), Kal, H.B. (author), Barendsen, G.W. (author)
Chemicals/CAS: vinblastine, 865-21-4; Vinblastine, 865-21-4
article 1980
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Radiobiologisch Instituut TNO (author), Hermens, A.F. (author)
article 1980
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Radiobiologisch Instituut TNO (author), van Putten, L.M. (author), Smink, T. (author)
Chemicals/CAS: misonidazole, 13551-87-6; Nitroimidazoles; Radiation-Sensitizing Agents
article 1978
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Radiobiologisch Instituut TNO (author), Maat, B. (author)
Recent data on extrapulmonary colony formation after heparin administration are inconclusive. A systemic study of this topic was undertaken with 4 experimental tumour systems and 2 distinct periods of reduced clotting capacity in rats and mice. I.v. injection of various numbers of tumour cells into i.p. heparinized animals leads to: Significant...
article 1978
document
van Putten, L.M. (author), Kram, L.K.J. (author), van Dierendonck, H.H.C. (author), Radiobiologisch Instituut TNO (author)
In studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. In contrast the application of cytostatic drugs and...
article 1975
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Radiobiologisch Instituut TNO (author), Sindram, P.J. (author), Snow, G.B. (author), van Putten, L.M. (author)
Chemicals/CAS: folinate calcium, 1492-18-8, 51057-63-7; folinic acid, 58-05-9, 68538-85-2; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; Leucovorin, 58-05-9; Methotrexate, 59-05-2
article 1974
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de Haas, J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
bookPart 1954
Searched for: subject%3A%22Cancer%22
(261 - 280 of 280)

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