Searched for: subject%3A%22Calcium%22
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Garrett, I.R. (author), Dallas, S. (author), Radl, J. (author), Mundy, G.R. (author), TNO Preventie en Gezondheid (author)
Myeloma causes a devastating and unique form of osteolytic bone disease. Although osteoclast activation is responsible for bone destruction, the precise mechanisms by which myeloma cells increase osteoclast activity have not been defined. An animal model of human myeloma bone disease mould help in clarification of these mechanisms. Multiple...
article 1997
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van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
article 1997
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Lupu, C. (author), Goodwin, C.A. (author), Westmuckett, A.D. (author), Emeis, J.J. (author), Scully, M.F. (author), Kakkar, V.V. (author), Lupu, F. (author), Gaubius Instituut TNO (author)
Tissue factor pathway inhibitor (TFPI), the main downregulator of the procoagulant activity of tissue factor·factor VIIa complex, locates in human endothelial cells (EC) in culture as well-defined clusters uniformly distributed both on the cell surface and intracellularly. We here demonstrate by immunofluorescence that TFPI colocalizes in EC...
article 1997
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Schaafsma, G. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: Calcium, 7440-70-2; Magnesium, 7439-95-4
article 1997
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van den Eijnden-Schrauwen, Y. (author), Atsma, D.E. (author), Lupu, F. (author), de Vries, R.E.M. (author), Kooistra, T. (author), Emeis, J.J. (author), TNO Preventie en Gezondheid (author)
In this study, we investigated the role of Ca2+ and G proteins in thrombin-induced acute release (regulated secretion) of tissue-type plasminogen activator (TPA) and yon Willebrand factor (vWF), using a previously described system of primary human umbilical vein endothelial cells (HUVECs). The acute release of TPA and vWF, as induced by α...
article 1997
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van Poppel, G. (author), van den Berg, H. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
The prospect that high intake of certain vitamins may confer protection against cancer has drawn substantial attention during the last decades. This paper gives a concise update of the role of a number of promising vitamins in prevention of cancer. Vitamin A and its analogues have an important role in cellular processes related to carcinogenesis...
article 1997
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Instituut CIVO-Toxicologie en Voeding TNO (author), Pannemans, D.L.E. (author), Schaafsma, G. (author), Westerterp, K.R. (author)
The present study was conducted to investigate the effect of dietary protein on urinary Ca excretion, apparent Ca absorption and Ca balance in young and elderly subjects. Young adults (n 29) and elderly persons (n 26) consumed diets containing 12% (diet A) and 21% (diet B) of total energy as protein for 3 weeks according to a randomized...
article 1997
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Wolterbeek, A.P.M. (author), Ciotti, M.A.L.T. (author), Schoevers, E.J. (author), Roggeband, R. (author), Baan, R.A. (author), Feron, V.J. (author), Rutten, A.A.J.J.L. (author), TNO Voeding (author)
Tracheal organ cultures and isolated tracheal epithelial cells are frequently used to study effects of carcinogens and retinoids on both proliferation and differentiation of respiratory tract epithelial cells. For each of these in vitro models, optimal culture conditions have been established, varying in type of culture medium and composition of...
article 1996
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Nègre-Aminou, P. (author), Nemenoff, R.A. (author), Wood, M.R. (author), de la Houssaye, B.A. (author), Pfenninger, K.H. (author), Gaubius Instituut TNO (author)
Nerve growth cones isolated from fetal rat brain exhibit in their cytosol a robust level of phospholipase A2 activity hydrolyzing phosphatidylinositol (PI) and phosphatidylethanolamine (PE) but not phosphatidylcholine (PC). Western blot analysis with an antibody to the well- characterized cytosolic phospholipase A2 (mol wt 85, 000) reveals only...
article 1996
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Groten, J.P. (author), Schoen, E.D. (author), Feron, V.J. (author), TNO Voeding (author)
The use of factorial designs, in which n chemicals are studied at x(n) dose levels (x treatment groups), has been put forward as one of the valuable statistical approaches for hazard assessment of chemical mixtures. Very recently a '25 study' was presented to describe interactions between the carcinogenic activity of five polycyclic aromatic...
article 1996
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Wolterbeek, A.P.M. (author), Ciotti, M.A.L.T. (author), Schoevers, E.J. (author), Feron, V.J. (author), Rutten, A.A.J.J.L. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: benzo[a]pyrene, 50-32-8; calcium ion, 14127-61-8; retinol, 68-26-8, 82445-97-4
article 1996
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van der Meulen, R.M. (author), Visser, K. (author), Wang, M. (author)
We present data to elucidate the involvement of calcium ions in abscisic acid (ABA)-induced gene expression. Modulation of external calcium concentrations was able to affect ABA-induced specific RAB gene expression. At a constant ABA level with increasing extracellular calcium level, an increasing RAB mRNA expression was measured. In barley...
article 1996
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Kuijpers, M.H.M. (author), van de Kooij, A.J. (author), Slootweg, P.J. (author), TNO Voeding (author)
Microscopic examination of the incisors of rats and mice may reveal toxicologically significant changes. First, the incisor morphology reflects the nutritional status of the animal: fluctuations of mineral metabolism and vitamin availability are disclosed by the rodent incisors, because the incisors continue to grow during life. Similarly,...
article 1996
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Gaubius Instituut TNO (author), Schalkwijk, C.G. (author), van der Heijden, M.A.G. (author), Bunt, G. (author), Maas, R. (author), Tertoolen, L.G.J. (author), van Bergen Henegouwen, P.M.P. (author), Verkleij, A.J. (author), van den Bosch, H. (author), Boonstra, J. (author)
The 85 kDa cytosolic phospholipase A2 (cPLA2) preferentially catalyses the hydrolysis of arachidonic acid from the sn-2 position of phospholipids. cPLA2 can be activated by extracellular stimuli such as thrombin, platelet-derived growth factor and epidermal growth factor (EGF). A full activation of cPLA2 requires an increase of intracellular Ca2...
article 1996
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van der Pluijm, R. (author), TNO Bouw (author)
In the framework of European test methods for masonry a simple test method for bond has to be established. The described research, carried out at Eindhoven University of Technology, tried to contribute to the development of such a test method. In this perspective, the research was focused on bond wrench testing. To investigate the outcome of the...
conference paper 1996
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), van Dokkum, W. (author), dela Guéronnière, V. (author), Schaafsma, G. (author), Bouley, C. (author), Luten, J. (author), Latgé, C. (author)
True fractional Ca absorption from six foods was measured in twelve normal healthy women, aged 20-29 years. The tested foods were commercially available fresh cheese, fresh cheese prepared by new technology and rich in Ca, similar cheese with added Fe, enteral food, mineral water alone and combined with a spaghetti meal. The aim of the study was...
article 1996
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Draijer, R. (author), Atsma, D.E. (author), van der Laarse, A. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Previous studies have demonstrated that cGMP and cAMP reduce the endothelial permeability for fluids and macromolecules when the endothelial permeability is increased by thrombin. In this study, we have investigated the mechanism by which cGMP improves the endothelial barrier function and examined whether nitric oxide (NO) can serve as an...
article 1995
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Draijer, R. (author), Vaandrager, A.B. (author), Nolte, C. (author), de Jonge, H.R. (author), Walter, U. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Previous studies demonstrated that the thrombin-induced permeability of endothelial cell monolayers is reduced by the elevation of cGMP. In the present study, the presence of cGMP-dependent protein kinase (cGMP-PK) immunoreactivity and activity in various types of human endothelial cells (ECs) and the role of cGMP-PK in the reduction of thrombin...
article 1995
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Pieters, R.H.H. (author), Punt, P. (author), Bol, M. (author), van Dijken, J.M. (author), Seinen, W. (author), Penninks, A.H. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
In the present study, we show that the thymus atrophy inducing compound DBTC stimulates the intracellular release, but not the influx, of Ca2+ elicited by cross-linking of the TcRαβ-CD3-complex on rat thymocytes and inhibits capping of TcRαβ. Similarities with the effects of cytochalasin B together with the finding that DBTC also inhibited...
article 1995
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Sloot, W.N. (author), van der Sluijs-Gelling, A.J. (author), Gramsbergen, J.B.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Regional 45Ca2+ accumulation and analysis of monoamines and metabolites in dissected tissues were used to localize, quantify, and characterize brain damage after intracerebral injections of Mn2+ into striatum and hippocampus. The specificity of Mn2+-induced lesions is described in relation to brain damage produced by local Fe2+ or 6-...
article 1994
Searched for: subject%3A%22Calcium%22
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