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van der Does, A.M. (author), Amatngalim, G.D. (author), Keijser, B.J.F. (author), Hiemstra, P.S. (author), Villenave, R. (author)The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of...article 2018
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Beijers, R.J.H.C.G. (author), Huysmans, S.M.D. (author), van de Bool, C. (author), Kingma, B.R.M. (author), Verdijk, A.B. (author), Loon, L.J.C. (author), Meex, S.J.R. (author), Gosker, H.R. (author), Schols, A.M.W.J. (author)Background & aims : Many COPD patients have a reduced exercise capacity and mechanical efficiency and are at increased cardiometabolic risk. This study aimed to assess acute and 7-days effects of dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with COPD. Methods : This double-blind, randomized...article 2018
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Zarcone, M.C. (author), van Schadewijk, A. (author), Duistermaat, E. (author), Hiemstra, P.S. (author), Kooter, I.M. (author)Background: Exacerbations constitute a major cause of morbidity and mortality in patients suffering from chronic obstructive pulmonary disease (COPD). Both bacterial infections, such as those with non-typeable Haemophilus influenzae (NTHi), and exposures to diesel engine emissions are known to contribute to exacerbations in COPD patients....article 2017
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Rottenkolber, M. (author), Voogd, E. (author), van Dijk, L. (author), Primatesta, P. (author), Becker, C. (author), de Groot, M.C.H. (author), Plana, E. (author), Alvarez, Y. (author), Durand, J. (author), Slattery, J. (author), Afonso, A. (author), Requena, G. (author), Huerta, C. (author), Alvarez, A. (author), de Abajo, F. (author), Tauscher, M. (author), Hasford, J. (author), Fischer, R. (author), Reynolds, R. (author), Schmiedl, S. (author)Background: For patients with asthma, COPD, or asthma-COPD overlap syndrome (ACOS), inter-country comparisons of seasonal changes in drug prescriptions are scarce or missing. Hence, we aimed to compare seasonal changes in prescription rates of long-acting beta-2-agonist (LABA) in four European countries. Methods: A common study protocol was...article 2015