Searched for: subject%3A%22CD4%255C%257Eplus%257E%255C%2BT%255C%2Blymphocyte%22
(1 - 7 of 7)
document
Mariman, R. (author), Kremer, S.H.A. (author), van Erk, M. (author), Lagerweij, T. (author), Koning, F. (author), Nagelkerken, L. (author)
Background: Host-microbiota interactions in the intestinal mucosa play a major role in intestinal immune homeostasis and control the threshold of local inflammation. The aim of this study was to evaluate the efficacy of probiotics in the recurrent trinitrobenzene sulfonic acid (TNBS)-induced colitis model and gain more insight into protective...
article 2012
document
Kel, J.M. (author), Slütter, B. (author), Drijfhout, J.W. (author), Koning, F. (author), Nagelkerken, L. (author), TNO Kwaliteit van Leven (author)
Tolerance to experimental autoimmune encephalomyelitis (EAE) in SJL mice can be induced by immunization with a mannosylated form of the proteolipid protein (M-PLP139-151), despite the presence of CFA. The state of tolerance is characterized by poor delayed-type hypersensitivity responses and the absence of clinical EAE symptoms. In vivo...
article 2008
document
Nolte-'t Hoen, E.N.M. (author), Boot, E.P.J. (author), Wagenaar-Hilbers, J.P.A. (author), van Bilsen, J.H.M. (author), Arkesteijn, G.J.A. (author), Storm, G. (author), Everse, L.A. (author), van Eden, W. (author), Wauben, M.H.M. (author), TNO Kwaliteit van Leven (author)
Major problems in the analysis of CD4+ effector cell and regulatory T cell (Treg) populations in an activated immune system are caused by the facts that both cell types can express CD25 and that the discriminatory marker forkhead box p3 can only be analyzed in nonviable (permeabilized) cells. Here, we show that CD134 (OX40) can be used as a...
article 2008
document
Kel, J.M. (author), de Geus, E.D. (author), van Stipdonk, M.J. (author), Drijfhout, J.W. (author), Koning, F. (author), Nagelkerken, L. (author), TNO Kwaliteit van Leven (author)
In this study, we investigated the development of T cell responses in mice after administration of a mannosylated ovalbumin peptide (M-OVA323-339). Immunization with M-OVA323-339 in complete adjuvant resulted in enhanced antigen presentation in draining lymph nodes. Monitoring the fate of CFSE-labeled ovalbumin peptide-specific TCR transgenic...
article 2008
document
Zafranskaya, M. (author), Oschmann, P. (author), Engel, R. (author), Weishaupt, A. (author), van Noort, J.M. (author), Jomaa, H. (author), Eberl, M. (author), TNO Kwaliteit van Leven (author)
Therapy with interferon-β (IFN-β) has well-established clinical effects in multiple sclerosis (MS), albeit the immunomodulatory mechanisms are not fully understood. We assessed the prevalence and functional capacity of CD4+ and CD8+ T cells in healthy donors, and in untreated and IFN-β-treated MS patients, in response to myelin oligodendrocyte...
article 2007
document
Arts, J.H.E. (author), Mommers, C. (author), de Heer, C. (author), TNO Kwaliteit van Leven (author)
A literature study was performed to evaluate dose-response relationships and no-effect levels for sensitization and elicitation in skin- and respiratory allergy. With respect to the skin, dose-response relationships and no-effect levels were found for both intradermal and topical induction, as well as for intradermal and topical elicitation of...
article 2006
document
Wang, C. (author), Chou, Y.K. (author), Rich, C.M. (author), Link, J.M. (author), Afentoulis, M.E. (author), van Noort, J.M. (author), Wawrousek, E.F. (author), Offner, H. (author), van den Bark, A.A. (author), TNO Kwaliteit van Leven (author)
Alpha B-crystallin (αB) is a small heat shock protein that is strongly up-regulated in multiple sclerosis (MS) brain tissue, and can induce strong T cell responses. Assessing a potential encephalitogenic function for αB protein in MS and experimental autoimmune encephalomyelitis (EAE) has been challenging due to its ubiquitous expression that...
article 2006
Searched for: subject%3A%22CD4%255C%257Eplus%257E%255C%2BT%255C%2Blymphocyte%22
(1 - 7 of 7)