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TNO Kwaliteit van Leven (author), Rotteveel, J. (author), Belksma, E.J. (author), Renders, C.M. (author), Hirasing, R.A. (author), Delemarre-Van de Waal, H.A. (author)Objective: The worldwide trend towards obesity in childhood is also observed in the Netherlands and one of the consequences may be type 2 diabetes. In this study, we assessed the number of children with type 2 diabetes, diagnosed by paediatricians, in the Netherlands. Methods: In 2003 and 2004 the Dutch Paediatric Surveillance Unit, a nationwide...article 2007
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Finken, M.J.J. (author), Keijzer-Veen, M.G. (author), Dekker, F.W. (author), Frölich, M. (author), Hille, E.T.M. (author), Romijn, J.A. (author), Wit, J.M. (author), TNO Kwaliteit van Leven (author)Aims/hypothesis: An increased risk of type 2 diabetes mellitus is associated with low birthweight after full-term gestation, including amplification of this risk by weight gain during infancy and adult body composition. Premature birth is also associated with insulin resistance, but studies conducted so far have not provided follow-up into...article 2006
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Sierksma, A. (author), Patel, H. (author), Ouchi, N. (author), Kihara, S. (author), Funahashi, T. (author), Heine, R.J. (author), Grobbee, D.E. (author), Kluft, C. (author), Hendriks, H.F.J. (author), TNO Preventie en Gezondheid (author)OBJECTIVE - Epidemiological studies suggest that moderate alcohol consumers have enhanced insulin sensitivity and a reduced risk of type 2 diabetes. Adiponectin, an adipocyte-derived plasma protein, has been found to be negatively associated with adiposity and positively associated with insulin sensitivity. Moderate alcohol consumption may...article 2004
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), Valtueña, S. (author), Cashman, K. (author), Robins, S.P. (author), Cassidy, A. (author), Kardinaal, A. (author), Branca, F. (author)Research on the bone effects of natural phyto-oestrogens after menopause is at a relatively early stage. Published studies are few, difficult to compare and often inconclusive, due in part to design weaknesses. Currently, many questions remain to be answered including to what extent a safe daily intake may prevent postmenopausal bone loss. These...article 2003
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Brussaard, H.E. (author), Gevers Leuven, J.A. (author), Frölich, M. (author), Kluft, C. (author), Krans, H.M.J. (author), Gaubius Instituut TNO (author)Oestrogen replacement therapy is associated with a decreased risk of cardiovascular disease in postmenopausal women. Patients with non-insulin- dependent diabetes mellitus (NIDDM) have an increased cardiovascular risk. However, oestrogen replacement therapy is only reluctantly prescribed for patients with NIDDM. In a double blind randomized...article 1997