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Koivisto, A.J. (author), Kling, K.I. (author), Fonseca, A.S. (author), Brostrøm Bluhme, A. (author), Moreman, M. (author), Yu, M. (author), Costa, A.L. (author), Giovanni, B. (author), Ortelli, S. (author), Fransman, W. (author), Vogel, U. (author), Jensen, K.A. (author)Nanoscale TiO2 (nTiO2) is manufactured in high volumes and is of potential concern in occupational health. Here, we measured workers exposure levels while ceramic honeycombs were dip coated with liquid photoactive nanoparticle suspension and dried with an air blade. The measured nTiO2 concentration levels were used to assess process specific...article 2018
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Kooter, I.M. (author), Grollers-Mulderij, M. (author), Duistermaat, E. (author), Kuper, C.F. (author)Mucilair 3D bronchial airway models, cultured at an air-liquid interface, were exposed to aerosols of copper oxide (CuO) nanoparticles in Vitrocell air exposure modules. Four cell donors, four exposure modules and four exposure concentrations were varied within four different exposure sessions using a statistical experimental design called a...article 2017
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Respiratory sensitization: Advances in assessing the risk of respiratory inflammation and irritationVandebriel, R. (author), Callant Cransveld, C. (author), Crommelin, D. (author), Diamant, Z. (author), Glazenburg, B. (author), Joos, G. (author), Kuper, F. (author), Natsch, A. (author), Nijkamp, F. (author), Noteborn, H. (author), Pieters, R. (author), Roberts, D. (author), Roggen, E. (author), Rorije, E. (author), Seed, M. (author), Sewald, K. (author), van den Heuvel, R. (author), van Engelen, J. (author), Verstraelen, S. (author), van Loveren, H. (author)Respiratory sensitization provides a case study for a new approach to chemical safety evaluation, as the prevalence of respiratory sensitization has increased considerably over the last decades, but animal and/or human experimental/predictive models are not currently available. Therefore, the goal of a working group was to design a road map to...article 2011
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Pronk, A. (author), Preller, L. (author), Doekes, G. (author), Wouters, I.M. (author), Rooijackers, J. (author), Lammers, J.-W. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Associations have been observed between exposure to isocyanates, consisting mainly of oligomers, and respiratory symptoms and isocyanate specific sensitisation in spray painters. The aim of the present study was to assess associations between isocyanate exposure and more objective respiratory effect measures such as bronchial hyperresponsiveness...article 2009
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Kuper, C.F. (author), TNO Kwaliteit van Leven (author)Mucosa-associated lymphoid tissue (MALT) is a generalized term incorporating a disseminated collection of lymphoid tissues in multiple sites throughout the body. MALT sites that have been/are primarily studied include bronchus-associated lymphoid tissue (BALT), gut-associated lymphoid tissue (GALT), and nasopharynx-associated lymphoid tissue ...article 2006