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- de Marchi, T. (author), Braakman, R.B.H. (author), Stingl, C. (author), van Duijn, M.M. (author), Smid, M. (author), Foekens, J.A. (author), Luider, T.M. (author), Martens, J.W.M. (author), Umar, A. (author) article 2016
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Koppes, L.J.J. (author), Geuskens, G.A. (author), Pronk, A. (author), Vermeulen, R.C.H. (author), de Vroome, E.M.M. (author)Experimental studies in animals indicate that disruption of the circadian rhythm is carcinogenic, and night work has been suggested to be a probable breast cancer cause in humans. Findings among humans, however are inconsistent, often gathered with retrospective study designs, and only based on specific populations, such as nurses. We used data...article 2014
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Hogervorst, J.G. (author), Schouten, L.J. (author), Konings, E.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Background: Acrylamide, a probable human carcinogen, was detected in various heat-treated carbohydrate-rich foods in 2002. The few epidemiologic studies done thus far have not shown a relationship with cancer. Our aim was to investigate the association between acrylamide intake and endometrial, ovarian, and breast cancer risk. Methods: The...article 2007
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Koushik, A. (author), Hunter, D.J. (author), Spiegelman, D. (author), Anderson, K.E. (author), Buring, J.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Hankinson, S.E. (author), Larsson, S.C. (author), Leitzmann, M. (author), Marshall, J.R. (author), McCullough, M.L. (author), Miller, A.B. (author), Rodriguez, C. (author), Rohan, T.E. (author), Ross, J.A. (author), Schatzkin, A. (author), Schouten, L.J. (author), Willett, W.C. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)Carotenoids, found in fruits and vegetables, have the potential to protect against cancer because of their properties, including their functions as precursors to vitamin A and as antioxidants. We examined the associations between intakes of α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin and lycopene and the risk of invasive...article 2006
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Visser, O. (author), van Peppen, A.M. (author), Öry, F.G. (author), van Leeuwen, F.E. (author), TNO Preventie en Gezondheid (author)To determine breast cancer screening results according to country of birth data were used from the breast cancer screening organization of the Comprehensive Cancer Centre Amsterdam, the Netherlands. Overall (age-adjusted) attendance of the breast cancer screening was 76% for women aged 50-69. Attendance was significantly lower for women born in...article 2005
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Männistö, S. (author), Dixon, L.B. (author), Balder, H.F. (author), Virtanen, M.J. (author), Krogh, V. (author), Khani, B.R. (author), Berrino, F. (author), van den Brandt, P.A. (author), Hartman, A.M. (author), Pietinen, P. (author), Tan, F. (author), Wolk, A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)Objective: Only a few consistent findings on individual foods or nutrients that influence breast cancer risk have emerged thus far. Since people do not consume individual foods but certain combinations of them, the analysis of dietary patterns may offer an additional aspect for assessing associations between diet and diseases such as breast...article 2005
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WU/TNO Center for Food Toxicology (author), van der Woude, H. (author), ter Veld, M.G.R. (author), Jacobs, N. (author), van der Saag, P.T. (author), Murk, A.J. (author), Rietjens, I.M.C.M. (author)Quercetin causes biphasic modulation of the proliferation of specific colon and mammary cancer cells. In this study, the possible involvement of the estrogen receptor (ER) in the stimulation of cell proliferation by quercetin was investigated. For this purpose, the effect of quercetin on cell prolifera-tion was tested in ER-positive MCF-7 and...article 2005
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van Zanden, J.J. (author), Geraets, L. (author), Wortelboer, H.M. (author), van Bladeren, P.J. (author), Rietjens, I.M.C.M. (author), Cnubben, N.H.P. (author), TNO Voeding (author)The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5). The results reveal that GSTP1-1 activity in MCF7 pMTG5 cells can be inhibited by some...article 2004
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TNO Preventie en Gezondheid (author), Visser, O. (author), van der Kooy, K. (author), van Peppen, A.M. (author), Öry, F.G. (author), van Leeuwen, F.E. (author)We investigated breast cancer incidence in migrants in the Netherlands in 1988-1998. The standardised incidence ratio for breast cancer in Northwest-Netherlands was statistically significantly reduced for women born in Surinam (0.56), Turkey (0.29) and Morocco (0.22). The proportion of women with advanced stages (III and IV) did not differ...article 2004
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Voorrips, L.E. (author), Brants, H.A.M. (author), Kardinaal, A.F.M. (author), Hiddink, G.J. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Background: Conjugated linoleic acid (CLA), which is present in milk products and meat from ruminants, appears to have anticarcinogenic activity against breast cancer in animal and in vitro experiments. To date, few epidemiologic data are available in humans. Objective: This study evaluated the relation between intakes of CLA and other fatty...article 2002
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Missmer, S.A. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Yaun, S.-S. (author), Adami, H.-O. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Fraserf, G.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Graham, S. (author), Kushi, L.H. (author), Miller, A.B. (author), Potter, J.D. (author), Rohan, T.E. (author), Speizer, F.E. (author), Toniolo, P. (author), Willett, W.C. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Hunter, D.J. (author)Background. More than 20 studies have investigated the relation between meat and dairy consumption and breast cancer risk with conflicting results. Our objective was evaluate the risk of breast cancer associated with meat and dairy food consumption and to assess whether non-dietary risk factors modify the relation. Methods. We combined the...article 2002
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Smith-Warner, S.A. (author), Spiegelman, D. (author), Yaun, S.-S. (author), Adami, H.O. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Potter, J.D. (author), Rohan, T.E. (author), Speizer, F.E. (author), Toniolo, P. (author), Willett, W.C. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Hunter, D.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Context: Some epidemiologic studies suggest that elevated fruit and vegetable consumption is associated with a reduced risk of breast cancer. However, most have been case-control studies in which recall and selection bias may influence the results. Additionally, publication bias may have influenced the literature on associations for specific...article 2001
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Smith-Warner, S.A. (author), Spiegelman, D. (author), Adami, H.O. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Graham, S. (author), Kushi, L.H. (author), Miller, A.B. (author), Rohan, T.E. (author), Speizer, F.E. (author), Toniolo, P. (author), Willett, W.C. (author), Wolk, A. (author), Zelenuch-Jacquotte, A. (author), Hunter, D.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Recently, there has been interest in whether intakes of specific types of fat are associated with breast cancer risk independently of other types of fat, but results have been inconsistent. We identified 8 prospective studies that met predefined criteria and analyzed their primary data using a standardized approach. Holding total energy intake...article 2001
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TNO Preventie en Gezondheid (author), Jonsson, E. (author), David Banta, H. (author), Scherstén, T. (author)Objectives: To describe health technology assessment (HTA) and policies concerning three screening procedures in Sweden. Methods: The main source of information was reports from the Swedish Council for Technology Assessment in Health Care (SBU) and other governmental reports, supplemented by the professional literature. Results: Prevention is...article 2001
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Blankvoort, B.M.G. (author), de Groene, E.M. (author), van Meeteren-Kreikamp, A.P. (author), Witkamp, R.F. (author), Rodenburg, R.J.T. (author), Aarts, J.M.M.J.G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The aim of the work described in this report is to develop and characterize a cell-based androgen reporter assay. For this purpose, the androgen receptor (AR) expressing human breast cancer cell line T47D was stably transfected with a luciferase gene under transcriptional control of the PB-ARE-2 androgen response element. The application of this...article 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Branca, F. (author), Hanley, A.B. (author), Pool-Zobel, B. (author), Verhagen, H. (author)Biomarkers have considerable potential in aiding the understanding of the relationship between diet and disease or health. However, to assess the role, relevance and importance of biomarkers on a case by case basis it is essential to understand and prioritise the principal diet and health issues. In the majority of cases, dietary compounds are...article 2001
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TNO Kwaliteit van Leven (author), Banta, H.D. (author), Oortwijn, W. (author)Objective: To review the assessment and implementation of three screening methods: mammography for breast cancer, screening for prostate cancer, and routine use of ultrasound in pregnancy. Methods: To review policy documents and published papers dealing with prevention and screening in the Netherlands, focusing on the three screening methods...article 2001
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Hanemaaijer, R. (author), Verheijen, J.H. (author), Maguire, T.M. (author), Visser, H. (author), Toet, K. (author), McDermott, E. (author), O'Higgins, N. (author), Duffy, M.J. (author), Gaubius Instituut TNO (author)Matrix metalloproteinases (MMP) types 2 and 9 (also known as gelatinase A and B) are thought to be causally involved in cancer invasion and metastasis. In normal as well as in malignant tissue, both these MMPs occur in multiple forms such as inactive precursors, active enzymes and enzyme- inhibitor complexes. Using newly developed quantitative...article 2000
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- Teronen, O. (author), Laitinen, M. (author), Salo, T. (author), Hanemaaijer, R. (author), Heikkilä, P. (author), Konttinen, Y.T. (author), Sorsa, T. (author), TNO Preventie en Gezondheid (author) article 2000
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van den Brandt, P.A. (author), Spiegelman, D. (author), Yaun, S-S. (author), Adami, H-O. (author), Beeson, L. (author), Folsom, A.R. (author), Fraser, G. (author), Goldbohm, R.A. (author), Graham, S. (author), Kushi, L. (author), Marshall, J.R. (author), Miller, A.B. (author), Rohan, T. (author), Smith-Warner, S.A. (author), Speizer, F.E. (author), Willett, W.C. (author), Wolk, A. (author), Hunter, D.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. In multivariate analyses controlling for reproductive, dietary, and other risk factors, the pooled...article 2000
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