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Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study

Steevens, J. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)

Prospective epidemiologic data on vegetables and fruits consumption and risk of subtypes of esophageal and gastric cancer are sparse. We studied the association between vegetables and fruits consumption and risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA) and gastric...

article 2011

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Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli

Vermeulen, M. (author), Klöpping-Ketelaars, I.W.A.A. (author), van den Berg, R. (author), Vaes, W.H.J. (author), TNO Kwaliteit van Leven (author), KvL (author)

The aim of this study was to determine the bioavailability and kinetics of the supposed anticarcinogen sulforaphane, the hydrolysis product of glucoraphanin, from raw and cooked broccoli. Eight men consumed 200 g of crushed broccoli, raw or cooked, with a warm meal in a randomized, free-living, open cross-over trial. Higher amounts of...

article 2008

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Development of an enzyme-linked immunosorbent assay method to detect mustard protein in mustard seed oil

Koppelman, S.J. (author), Vlooswijk, R. (author), Bottger, G. (author), van Duijn, G. (author), van der Schaft, P. (author), Dekker, J. (author), van Bemgen, H. (author), TNO Kwaliteit van Leven (author)

An enzyme-linked immunosorbent assay for the detection of mustard protein was developed. The assay is based on a polyclonal antiserum directed against a mixture of mustard proteins raised in rabbits. The assay has a detection limit of 1.5 ppm (milligrams per kilogram) and is suitable for the detection of traces of mustard protein in mustard seed...

article 2007

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Consumption of vegetables and fruits and risk of ovarian carcinoma: Results from the Netherlands Cohort Study on Diet and Cancer

Mommers, M. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)

BACKGROUND. To the authors' knowledge, only a few prospective studies to date have investigated the correlation between vegetable and fruit consumption and the risk of ovarian carcinoma and their results have been inconclusive. METHODS. Vegetable and fruit intake was assessed in relation to ovarian carcinoma, among 62,573 postmenopausal women...

article 2005

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Determination of polar organophosphorus pesticides in vegetables and fruits using liquid chromatography with tandem mass spectrometry: Selection of extraction solvent

Mol, H.G.J. (author), van Dam, R.C.J. (author), Steijger, O.M. (author), TNO Voeding (author)

A method based on liquid chromatography (LC)-mass spectrometry (MS)/MS was developed for sensitive determination of a number of less gas chromatography (GC)-amenable organophosphorus pesticides (OPs; acephate, methamidophos, monocrotophos, omethoate, oxydemeton-methyl and vamidothion) in cabbage and grapes. For extraction, several solvents were...

article 2003

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Survival of human and plant pathogens during anaerobic mesophilic digestion of vegetable, fruit, and garden waste

Termorshuizen, A.J. (author), Volker, D. (author), Blok, W.J. (author), ten Brummeler, E. (author), Hartog, B.J. (author), Janse, J.D. (author), Knol, W. (author), Wenneker, M. (author), TNO Voeding (author)

Five pathogens were added to vegetable, fruit and garden waste and their survival was studied during mesophilic (maximum temperature 40°C) anaerobic digestion. Digestion during 6 weeks took place with a 50/50% (v/v) ratio of digested and fresh, undigested material, respectively. Survival of the plant pathogens Fusarium oxysporum f.sp. asparagi...

article 2003

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Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model

Krul, C.A.M. (author), Humblot, C. (author), Philippe, C. (author), Vermeulen, M. (author), van Nuenen, M. (author), Havenaar, R. (author), Rabot, S. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Cruciferous vegetables, such as Brassica, which contain substantial quantities of glucosinolates, have been suggested to possess anticarcinogenic activity. Cutting and chewing of cruciferous vegetables releases the thioglucosidase enzyme myrosinase, which degrades glucosinolates to isothiocyanates and other minor metabolites. Cooking of...

article 2002

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A critical assessment of some biomarker approaches linked with dietary intake

Centraal Instituut voor Voedingsonderzoek TNO (author), Crews, H. (author), Alink, G. (author), Andersen, R. (author), Braesco, V. (author), Holst, B. (author), Maiani, G. (author), Ovesen, L. (author), Scotter, M. (author), Solfrizzo, M. (author), van den Berg, R. (author), Verhagen, H. (author), Williamson, G. (author)

In this review many examples are given of the complexities involved in using some biomarkers in relation to assessing the effects of dietary exposure, when there is frequently a need to determine changes following long-term low level exposure to dietary components. These range from understanding why the biomarker might be valuable and how best...

article 2001

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Vegetable and fruit consumption and lung cancer risk in the Netherlands: Cohort study on diet and cancer

Voorrips, L.E. (author), Goldbohm, R.A. (author), Verhoeven, D.T.H. (author), van Poppel, G.A.F.C. (author), Sturmans, F. (author), Hermus, R.J.J. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)

Objective: The purpose was to study the association between vegetable and fruit consumption and lung cancer incidence using 1074 cases after 6.3 years of follow-up in the Netherlands Cohort Study. Methods: Dietary intake was assessed using a 150-item food-frequency questionnaire. Multivariate models were used including age, sex, family history...

article 2000

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Brassica vegetables and cancer prevention: Epidemiology and mechanisms

van Poppel, G. (author), Verhoeven, D.T.H. (author), Verhagen, H. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

This paper first gives an overview of the epidemiological data concerning the cancer-preventive effect of brassica vegetables, including cabbages, kale, broccoli, Brussels sprouts, and cauliflower. A protective effect of brassicas against cancer may be plausible due to their relatively high content of glucosinolates. Certain hydrolysis products...

article 2000

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Vegetable and fruit consumption and risks of colon and rectal cancer in a prospective cohort study

Voorrips, L.E. (author), Goldbohm, R.A. (author), van Poppel, G. (author), Sturmans, F. (author), Hermus, R.J.J. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

The relation between vegetable and fruit consumption and colorectal cancer risk was comprehensively assessed in the Netherlands Cohort Study on Diet and Cancer using a validated 150-item food frequency questionnaire. After 6.3 years of follow-up (1986-1992), over 1,000 incident cases of colorectal cancer were registered. Using case-cohort...

article 2000

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In vitro and in vivo inhibition of human flavin-containing monooxygenase form 3 (FMO3) in the presence of dietary indoles

Cashman, J.R. (author), Xiong, Y. (author), Lin, J. (author), Verhagen, H. (author), van Poppel, G. (author), van Bladeren, P.J. (author), Larsen-Su, S. (author), Williams, D.E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

The effect of consumption of glucosinolate-containing Brussels sprouts on flavin-containing monooxygenase functional activity in humans was investigated in 10 healthy, male, non-smoking volunteers. After a 3-week run-in period, 5 volunteers continued on a glucosinolate-free diet for 3 weeks (control group), and 5 others consumed 300 g of cooked...

article 1999

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Two-generation reproductive toxicity study of plant stanol esters in rats

Whittaker, M.H. (author), Frankos, V.H. (author), Wolterbeek, A.P.M. (author), Waalkens-Berendsen, D.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Plant stanol esters are intended for use as an ingredient in food to reduce the absorption of cholesterol from the gastrointestinal tract. Consumption of plant stanol esters has a demonstrated diet-derived public health benefit, as shown by numerous clinical studies. Plant stanol esters are ring-saturated analogs of common dietary sterols that...

article 1999

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Determination of the sulfur mustard hydrolysis product thiodiglycol by microcolumn liquid chromatography coupled on-line with sulfur flame photometric detection using large-volume injections and peak

Hooijschuur, E.W.J. (author), Kientz, C.E. (author), Brinkman, U.A.T. (author), TNO Prins Maurits Laboratorium (author)

A selective, direct and relatively rapid method has been developed for the determination of thiodiglycol (TDG) in aqueous samples. TDG is the main hydrolysis product of the chemical warfare agent sulfur mustard. The method of analysis is based on the on-line coupling of reversed-phase microcolumn liquid chromatography and sulfur-selective flame...

article 1999

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Nitrogen utilization in pigs fed diets with soybean and rapeseed products leading to different ileal endogenous nitrogen losses

Grala, W. (author), Verstegen, M.W.A. (author), Jansman, A.J.M. (author), Huisman, J. (author), Wasilewko, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Nitrogen (N) balance was determined in 36 pigs (BW 24 to 30 kg) fed diets inducing different ileal endogenous N losses (ENL). We tested the hypothesis that enhanced ENL may be indicative of a higher recycling of endogenous proteins that will induce a greater urinary N loss and a lower efficiency of the dietary N utilization for retention. The...

article 1998

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The contribution of various foods to intake of vitamin A and carotenoids in the Netherlands

Goldbohm, R.A. (author), Brants, H.A.M. (author), Hulshof, K.F.A.M. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

This study presents data on dietary intake of specific carotenoids in the Netherlands, based on a recently developed food composition database for carotenoids. Regularly eaten vegetables, the main dietary source of carotenoids, were sampled comprehensively and analysed with modern analytic methods. The database was complemented with data from...

article 1998

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A review of mechanisms underlying anticarcinogenicity by brassica vegetables

Verhoeven, D.T.H. (author), Verhagen, H. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), van Poppel, G. (author)

The mechanisms by which brassica vegetables might decrease the risk of cancer are reviewed in this paper. Brassicas, including all types of cabbages, broccoli, cauliflower and Brussels sprouts, may be protective against cancer due to their relatively high glucosinolate content. Glucosinolates are usually broken down through hydrolysis catalyzed...

article 1997

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Epidemiological studies on Brassica vegetables and cancer risk

Verhoeven, D.T.H. (author), Goldbohm, R.A. (author), van Poppel, G. (author), Verhagen, H. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

This paper gives an overview of the epidemiological data concerning the cancer-preventive effect of brassica vegetables, including cabbage, kale, broccoli, Brussels sprouts, and cauliflower. The protective effect of brassicas against cancer may be due to their relatively high content of glucosinolates. Certain hydrolysis products of...

article 1996

document

Effects of consumption of Brussels sprouts on plasma and urinary glutathione S-transferase class-α and -π in humans

Nijhoff, W.A. (author), Mulder, T.P.J. (author), Verhagen, H. (author), van Poppel, G. (author), Peters, W.H.M. (author)

The effects of consumption of glucosinolate-containing Brussels sprouts on plasma and urinary glutathione S-transferase (GST) class-α and -π were investigated. Five male and five female non-smoking volunteers were randomly assigned to two groups in a crossover design. Five persons started on a glucosinolate-free diet (control period), while the...

article 1995

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Reduction of oxidative DNA-damage in humans by Brussels sprouts

Verhagen, H. (author), Poulsen, H.E. (author), Loft, S. (author), van Poppel, G. (author), Willems, M.I. (author), van Bladeren, P.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

The effect of consumption of Brussels sprouts on levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in human urine was investigated in 10 healthy, male, non-smoking volunteers. Following a 3 week run-in period, five volunteers continued on a diet free of cruciferous vegetables for a subsequent 3 week intervention period (control group),...

article 1995