Thymus dependent immune competence; effects of ageing, tumour bearing and thymic humoral function

Identification of cells in primate bone marrow resembling the hemopoietic stem cell in the mouse

The colony forming unit culture (CFU C) in the thin layer agar colony technique is considered to be representative for hemopoietic stem cells (HSC), according to studies in mouse and monkey bone marrow. Using this in vitro assay as a guide, stem cell concentrates were prepared from monkey and human bone marrow by repeated density gradient...

Factors determining cell killing by chemotherapeutic agents In Vivo-II: Melphalan, chlorambucil and nitrogen mustard

The sensitivity of resting spleen colony-forming cells in normal mouse bone marrow and of rapidly-proliferating spleen colony-forming cells in repopulating mouse spleen to a number of bis-chloro-aethyl-amines was determined. The rapidly-growing cells were more sensitive to each of the agents than the resting cells. The equal degree of...