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Centraal Instituut voor Voedingsonderzoek TNO (author), Huisman, J. (author), Heinz, T. (author), van der Poel, A.F.B. (author), van Leeuwen, P. (author), Souffrant, W.B. (author), Verstegen, M.W.A. (author)The faecal and ileal true protein digestibilities of the raw pea (Pisum sativum) varieties finale and frijaune and the ileal true protein digestibility of steam-processed common beans (Phaseolus vulgaris) were measured in piglets using the 15N-dilution technique. The faecal true protein digestibility of both pea varieties was about 97. The ileal...article 1992
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Instituut CIVO-Toxicologie en Voeding TNO (author), Appel, M.J. (author), Meijers, M. (author), van Garderen-Hoetmer, A. (author), Lamers, C.B.H.W. (author), Rovati, L.C. (author), Sprij-Mooij, D. (author), Jansen, J.B.M.J. (author), Woutersen, R.A. (author)The role of cholecystokinin in dietary fat-promoted pancreatic carcinogenesis was investigated in azaserine-treated rats, using lorglumide, a highly specific cholecystokinin-receptor antagonist. The animals were killed 8 months after the start of treatment. Cholecystokinin, but not dietary unsaturated fat, increased pancreatic weight. Rats...article 1992
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Instituut CIVO-Toxicologie en Voeding TNO (author), Arts, C.J.M. (author), Govers, C.A.R.L. (author), van den Berg, H. (author), Blankenstein, M.A. (author), Thijssen, J.H.H. (author)Urinary and fecal estrogen excretion were studied in male rats fed a non-fiber wheat starch diet (dietary fiber < 1%; NF group; n = 4), a low-fiber wheat flour diet (dietary fiber 2%; LF group; n = 4) or a high-fiber wheat bran diet (dietary fiber 11.6%; HF group; n = 3). Short-term effects of the experimental diet on estrogen excretion were...article 1992
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Instituut CIVO-Toxicologie en Voeding TNO (author), Rutten, A.A.J.J.L. (author), de Groot, A.P. (author)Animal diets used in toxicity studies are prepared either from natural ingredients (cereal-based diet) or from more refined products (purified diet). The type of diet may influence both the outcome of the study and the values obtained with the various parameters in test and control animals. To detect the parameters sensitive to changes in diet...article 1992
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Gaubius Instituut TNO (author), de Knijff, P. (author), van den Maagdenberg, A.M.J.M. (author), Stalenhoef, A.F.H. (author), Leuven, J.A.G. (author), Demacker, P.N.M. (author), Kuyt, L.P. (author), Frants, R.R. (author), Havekes, L.M. (author)By the careful screening of familial dysbetalipoproteinemic (FD) patients, five probands showing heterozygosity for the APOE*3-Leiden allele were found. Genealogical studies revealed that these probands share common ancestry in the 17th century. In a group of 128 family members, spanning three generations, 37 additional heterozygous APOE*3...article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Poppel, G.van. (author), Schneijder, P. (author), Löwik, M.R.H. (author), Schrijver, J. (author), Kok, F.J. (author)As part of the Dutch Nutrition Surveillance System, cardiovascular risk factors and food consumption (24 h recall) as well as haematological, Fe and vitamin status (A, B6, C) were assessed in 126 Dutch boys aged 10-11 years (response 71%). Body mass index (BMI) and the sum of four skinfolds were strongly associated (r 0.85, P < 0.01) and 8% of...article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Groten, J.P. (author), Sinkeldam, E.J. (author), Luten, J.B. (author), van Bladeren, P.J. (author)The distribution of cadmium was examined in rats fed diets containing either cadmium-metallothionein (CdMt) or cadmium chloride (CdCl2) for 4 weeks. The test diets contained 3, 10, or 30 mg Cd/kg diet (3, 10, or 30 ppm) as CdMt or 30 mg Cd/kg diet (30 ppm) as CdCl2. A second study was performed to establish the Cd content in liver and kidneys...article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Reuzel, P.G.J. (author), Bruijntjes, J.P. (author), Feron, V.J. (author), Woutersen, R.A. (author)The inhalation toxicity of three amorphous silicas (Aerosol 200, Aerosil R 974 and Sipernat 22S) was compared with that of quartz dust. Rast were exposed to 1, 6 or 30 mg Aerosil 200/m3, 30 mg Aerosil R 974/m3, 30 mg Sipernat 22S/m3 or 60 mg quartz/m3 for 6 hr/day, 5 day/wk for 13 wk. Some rats were killed at the end of the exposure period and...article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Porter, M.C. (author), Kuijpers, M.H.M. (author), Mercer, G.D. (author), Hartnagel Jr., R.E. (author), Koeter, H.B.W.M. (author)The iv pathogenicity and toxigenicity of Protaminobacter rubrum was studied in New Zealand White rabbits and CF1 BR mice. Following a probe study, nine groups of six rabbits each were injected iv with: 1 ml of viable-cell suspension (VCS) at concentrations of 2.23 x 108, 106, 104 and 102 organisms/ml; the cell-free supernatants (CFS; in which...article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Meijers, M. (author), van Garderen-Hoetmer, A. (author), Lamers, C.B.H.W. (author), Rovati, L.C. (author), Jansen, J.B.M.J. (author), Woutersen, R.A. (author)Bombesin (BBS) has been shown to promote pancreatic growth as well as the development of pancreatic (pre)neoplasia in rats. The present study was carried out to determine the effects of bombesin on pancreatic growth and on the development of pancreatic (pre)neoplastic lesions in hamsters treated with N-nitrosobis(2-oxopropyl)amine (BOP)....article 1991
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Centraal Instituut voor Voedingsonderzoek TNO (author), Jonker, D. (author), Woutersen, R.A. (author), van Bladeren, P.J. (author), Til, H.P. (author), Feron, V.J. (author)In a 4-wk oral toxicity study, 4-wk-old male and female Wistar rats were exposed to a combination of arbitrarily chosen chemicals comprising sodium metabisulphite, Mirex, Loperamide, metaldehyde, di-n-octyltin dichloride, stannous chloride, lysinoalanine and potassium nitrite. The dose levels used were based on the 'no-observed-adverse-effect...article 1990
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Centraal Instituut voor Voedingsonderzoek TNO Instituut voor Landbouwkundig Onderzoek van Biochemische Produkten TNO (author), Huisman, J. (author), van der Poel, A.F.B. (author), van Leeuwen, P. (author), Verstegen, M.W.A. (author)The effects of lectins in the diet have been mainly studied in rats. An important question is whether results obtained in rats can be extrapolated to larger animals like the pig. Phaseolus vulgaris beans are rich in toxic lectins. Therefore a study was carried out to compare the effects of diets containing 200 g Phaseolus vulgaris beans (raw or...article 1990
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Centraal Instituut voor Voedingsonderzoek TNO (author), Lina, B.A.R. (author), Dreef-Van Der Meulen, H.C. (author), Leegwater, D.C. (author)Neohesperidin dehydrochalcone was administered to groups of 20 male and 20 female Wistar rats at dietary levels of 0, 0.2, 1.0 and 5.0% for 91 days. No treatment-related ophthalmoscopical, haematological or histopathological effects were observed. In the high-dose group, a marked caecal enlargement occurred in both sexes, accompanied by soft...article 1990
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Instituut CIVO-Toxicologie en Voeding TNO (author), Appel, M.J. (author), van Garderen-Hoetmer, A. (author), Woutersen, R.A. (author)Dietary fat has been shown to enhance pancreatic carcinogenesis. Uncertainty still exists whether the amount of linoleic acid or the amount of fat is the main determining factor. In the present study the effects of a high lard, a low lard, a linoleic acid supplemented low lard and a laboratory chow diet were investiated on the development of ...article 1990
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van Poppel, G. (author), Schrijver, J. (author), Meulmeester, J.F. (author), Kempen-Voogd, N. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Chemicals/CAS: Cholesterol, 57-88-5; Iron, 7439-89-6; Vitaminsarticle 1989
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Instituut voor experimentele gerontologie TNO (author), Boonstra-Nieveld, I.H.J. (author), van Bezooijen, C.F.A. (author)Hexobarbital is a drug widely used to study the capacity of the liver to metabolize drugs. The pharmacokinetics of hexobarbital in 3- and 30-month-old male BN/BiRij rats were studied. The half-life of hexobarbital in 30-month-old rats (34.9 ± 4.1 min) was significantly higher than that of 3-month-old ones (21.3 ± 3.8 min). The volume of...article 1989
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Hooftman, R.N. (author), Kuper, C.F. (author), Appelman, L.M. (author), Hoofdgroep Maatschappelijke Technologie TNO (author)The sensitivity of different parameters for the determination of lung injury caused by nitrogen dioxide (NO2) was investigated. Male rats were exposed to concentrations of 0, 4, 10 or 25 ppm NO2 for 6 h/day, for 7, 14 or 21 days. Histopathology of the nasal cavity, larynx, trachea and lungs was compared with the changes in macrophage function...article 1988
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- Til, H.P. (author), Feron, V.J. (author), Immel, H.R. (author), Vogel, W.F. (author), Instituut CIVO-Toxicologie en voeding TNO (author) article 1986
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Instituut CIVO-Toxicologie en voeding TNO (author), Woutersen, R.A. (author), Appelman, L.M. (author), van Garderen-Hoetmer, A. (author), Feron, V.J. (author)Male and female Wistar rats were exposed to acetaldehyde vapour at nominal concentrations 0, 750, 1500 or 3000/1000 ppm during 6 h/day, 5 days/week for up to 28 months. Major compound-related effects included increased mortality, growth retardation, nasal tumours, and non-neoplastic nasal changes in each of the test groups. The treatment-related...article 1986
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Reynders, J.B.J. (author), Immel, H.R. (author), Scherrenberg, P.M. (author), Feron, V.J. (author), Beems, R.B. (author), Instituut CIVO-Toxicologie en voeding TNO (author)Two groups of male and female Syrian golden hamsters, of which the trachea was severely injured by electrocoagulation, received 6 weekly intratracheal instillations of benzo[a]pyrene (BaP) + ferric oxide in saline or saline alone. Two comparable groups of hamsters were similarly treated but had an undamaged trachea. The experiment was terminated...article 1985