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Memelink, R. (author), Bongers, A. (author), Pasman, W. (author), van Rijmenam, M. (author), Wopereis, S. (author), Verlaan, G. (author), de Vogel Van den Bosch, J (author), Weijs, P.J.M. (author)Objectives. Weight loss is a key element in the treatment of obesity and type 2 diabetes (T2D), but also a risk factor for lean mass (LM) loss in older adults. We evaluated whether a whey protein drink enriched with leucine and vitamin D preserved LM during 3-month lifestyle intervention and whether effects sustained during 6 months follow-up...article 2020
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Tans, R. (author), van Diepen, J.A. (author), Bijlsma, S. (author), Verschuren, L. (author), Suppers, A. (author), Stienstra, R. (author), Wevers, R.A. (author), Tack, C.J. (author), Gloerich, J. (author), van Gool, A.J. (author)Background: Overweight and obesity can lead to adipose tissue inflammation, which causes insulin resistance and on the long-term type 2 diabetes mellitus (T2D). The inflammatory changes of obese-adipose tissue are characterized by macrophage infiltration and activation, but validated circulating biomarkers for adipose tissue inflammation for...article 2019
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Vesela, S. (author), Kingma, B.R.M. (author), Frijns, A.J.H. (author), van Marken Lichtenbelt, W.D. (author)The quality of local skin temperature prediction by thermophysiological models depends on the local skin blood flow (SBF) control functions. These equations were derived for low activity levels (0.8-1 met ) and mostly in sitting or supine position. This study validates and discusses the prediction of foot SBF during activities of 1-3 met in male...article 2019
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Schweiker, M. (author), Huebner, G.M. (author), Kingma, B.R.M. (author), Kramer, R. (author), Pallubinsky, H. (author)Understanding the drivers leading to individual differences in human thermal perception has become increasingly important, amongst other things due to challenges such as climate change and an ageing society. This review summarizes existing knowledge related to physiological, psychological, and context-related drivers of diversity in thermal...article 2018
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Shankar, K. (author), Pivik, R.T. (author), Johnson, S.L. (author), van Ommen, B. (author), Demmer, E. (author), Murray, R. (author)Understanding health requires more than knowledge of the genome. Environmental factors regulate gene function through epigenetics. Collectively, environmental exposures have been called the "exposome." Caregivers are instrumental in shaping exposures in a child's initial years. Maternal dietary patterns, physical activity, degree of weight gain,...article 2018
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Gerards, S.M.P.L. (author), Dagnelie, P.C. (author), Gubbels, J.S. (author), van Buuren, S. (author), Hamers, F.J.M. (author), Jansen, M.W.J. (author), van der Goot, O.H.M. (author), de Vries, N.K. (author), Sanders, M.R. (author), Kremers, S.P.J. (author)Introduction Lifestyle Triple P is a general parenting intervention which focuses on preventing further excessive weight gain in overweight and obese children. The objective of the current study was to assess the effectiveness of the Lifestyle Triple P intervention in the Netherlands. Method We used a parallel randomized controlled design to...article 2015
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de Hollander, E.L. (author), Zwart, L. (author), de Vries, S.I. (author), Wendel-Vos, W. (author)Objective: To examine whether the "Short QUestionnaire to ASsess Health-enhancing physical activity" (SQUASH) and the "Injuries and Physical Activity in the Netherlands" questionnaire ("Ongevallen en Bewegen in Nederland," OBiN) were valid in assessing adherence to physical activity (PA) guidelines. Study Design and Setting: Participants (N =...article 2012
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Willemsen, G. (author), de Geus, E.J.C. (author), Bartels, M. (author), van Beijsterveldt, C.E.M.T. (author), Brooks, A.I. (author), Estourgie-van Burk, G.F. (author), Fugman, D.A. (author), Hoekstra, C. (author), Hottenga, J.-J. (author), Kluft, K. (author), Meijer, P. (author), Montgomery, G.W. (author), Rizzu, P. (author), Sondervan, D. (author), Smit, A.B. (author), Spijker, S. (author), Suchiman, H.E.D. (author), Tischfield, J.A. (author), Lehner, T. (author), Slagboom, P.E. (author), Boomsma, D.I. (author), TNO Kwaliteit van Leven (author)In 2004 the Netherlands Twin Register (NTR) started a large scale biological sample collection in twin families to create a resource for genetic studies on health, lifestyle and personality. Between January 2004 and July 2008, adult participants from NTR research projects were invited into the study. During a home visit between 7:00 and 10:00 am...article 2010
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van den Hoek, A.M. (author), Teusink, B. (author), Voshol, P.J. (author), Havekes, L.M. (author), Romijn, J.A. (author), Pijl, H. (author), TNO Kwaliteit van Leven (author)Obese humans are often insulin- and leptin resistant. Since leptin can affect glucose metabolism, it is conceivable that a lack of leptin signal transduction contributes to insulin resistance. It remains unclear whether leptin affects glucose metabolism via peripheral and/or central mechanistic routes. In the present study, we aimed: (i) to...article 2008
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Stein, A.D. (author), Kahn, H.S. (author), Rundle, A. (author), Zybert, P.A. (author), van der Pal-de Bruin, K.M. (author), Lumey, L.H. (author), TNO Kwaliteit van Leven (author)Background: Few studies in humans have related maternal undernutrition to the size of the adult offspring. Objective: The objective was to assess whether reductions in food intake by pregnant women during the Dutch famine of 1944-1945 were related to offspring length, weight, and indexes of adiposity in middle age. Design: We recruited 1)...article 2007
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TNO Kwaliteit van Leven (author), Finken, M.J.J. (author)Children born small-for-gestational-age (SGA) are at risk for short stature, and cardiovascular disease and type 2 diabetes in later life. There is some preliminary evidence for a similar phenotype in survivors of preterm birth. In contrast to children born SGA, preterm infants born appropriate-for-gestational-age who experienced neonatal growth...doctoral thesis 2007
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Schaafsma, G. (author), TNO Kwaliteit van Leven (author)The increasing prevalence in many countries of people with overweight and obesity is undoubtedly one of the biggest threats to public health. Dietary proteins, because of their positive effects on satiation/ satiety, may help to reduce energy intake and promote a healthy body composition with less body fat. Several mechanisms have been put...article 2006
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Finken, M.J.J. (author), Keijzer-Veen, M.G. (author), Dekker, F.W. (author), Frölich, M. (author), Hille, E.T.M. (author), Romijn, J.A. (author), Wit, J.M. (author), TNO Kwaliteit van Leven (author)Aims/hypothesis: An increased risk of type 2 diabetes mellitus is associated with low birthweight after full-term gestation, including amplification of this risk by weight gain during infancy and adult body composition. Premature birth is also associated with insulin resistance, but studies conducted so far have not provided follow-up into...article 2006
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Beulens, J.W.J. (author), van Beers, R.M. (author), Stolk, R.P. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)Objective: To investigate the effect of moderate alcohol consumption on fat distribution, adipose tissue secreted proteins (adiponectin and resistin), and insulin sensitivity in healthy middle-aged men with abdominal obesity. Research Methods and Procedures: Thirty-four healthy men between 35 and 70 years old, with increased waist circumference ...article 2006
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Euser, A.M. (author), Finken, M.J.J. (author), Keijzer-Veen, M.G. (author), Hille, E.T.M. (author), Wit, J.M. (author), Dekker, F.W. (author)Background: Increasing evidence indicates that adult body composition is associated with prenatal and infancy weight gain, but the relative importance of different time periods has not been elucidated. Objective: The objective was to study the association between prenatal, early postnatal, and late infancy weight gain and body mass index (BMI),...article 2005
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Ferreira, I. (author), Snijder, M.B. (author), Twisk, J.W.R. (author), van Mechelen, W. (author), Kemper, H.C.G. (author), Seidell, J.C. (author), Stehouwer, C.D.A. (author), TNO Arbeid (author)Central and peripheral fatness seem to confer opposite (i.e. adverse vs. protective) effects on cardiovascular risk, but how this occurs is not clear. In addition, the role of peripheral lean mass needs to be elucidated. We therefore investigated, in 336 (175 women) 36-yr-old and apparently healthy adults, the relationship between trunk fat,...article 2004
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Dhonukshe-Rutten, R.A.M. (author), Lips, M. (author), de Jong, N. (author), Marijke, J.M.C.A.P. (author), Hiddink, G.J. (author), van Dusseldorp, M. (author), de Groot, L.C.P.G.M. (author), van Staveren, W.A. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Subclinical vitamin B-12 deficiency is common in the elderly. Encouraged by early indications, we investigated the plasma vitamin B-12 status in association with bone mineral content (BMC) and bone mineral density (BMD) in frail elderly people. Data of 194 free-living Dutch frail elderly (143 women and 51 men) were available. BMC and BMD were...article 2003
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Proper, K.I. (author), Koning, M. (author), van der Beek, A.J. (author), Hildebrandt, V.H. (author), Bosscher, R.J. (author), van Mechelen, W. (author)Objective: To critically review the literature with respect to the effectiveness of worksite physical activity programs on physical activity, physical fitness, and health. Data Sources: A search for relevant English-written papers published between 1980 and 2000 was conducted using MEDLINE, EMBASE, Sportdiscus, CINAHL, and Psychlit. The key...article 2003
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van Marken Lichtenbelt, W. (author), Daanen, H.A.M. (author)Purpose of review Cold response can be insulative (drop in peripheral temperature) or metabolic (increase in energy expenditure). Nonshivering thermogenesis by sympathetic, norepinephrine-induced mitochondrial heat production in brown adipose tissue is a well known component of this metabolic response in infants and several animal species. In...article 2003
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Szabó, C. (author), Jansman, A.J.M. (author), Babinszky, L. (author), Kanis, E. (author), Verstegen, M.W.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The effects of four protein sources (soybean meal, sunflower meal, pea, and fish meal as the main protein source) and three apparent ileally digestible Lys:DE ratios (0.50, 0.43, 0.36 and 0.42, 0.36, 0.30 g Lys/MJ DE for 30 to 60 kg BW and 60 to 105 kg BW, respectively) in pig diets on growing-finishing performance, and carcass and meat quality...article 2001
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