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Gayban, A.J.B. (author), Souza, L.A.C. (author), Cooper, S.G. (author), Regalado, E. (author), Kleemann, R. (author), Earley, Y.F. (author)Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver damage directly related to diabetes, obesity, and metabolic syndrome. The (pro)renin receptor (PRR) has recently been demonstrated to play a role in glucose and lipid metabolism. Here, we test the hypothesis that the PRR regulates the development of diet-induced hepatic...article 2023
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Schrieks, I.C. (author), Heil, A.L. (author), Hendriks, H.F. (author), Mukamal, K.J. (author), Beulens, J.W. (author)OBJECTIVE: Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes. This reduced risk might be explained by improved insulin sensitivity or improved glycemic status, but results of intervention studies on this relation are inconsistent. The purpose of this study was to conduct a systematic review and meta-analysis of...article 2015
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Bodin, J. (author), Kocbach Bølling, A. (author), Wendt, A. (author), Eliasson, L. (author), Becher, R. (author), Kuper, F. (author), Løvik, M. (author), Nygaard, U.C. (author)Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic beta-cells due to a genetic predisposition and can be triggered by environmental factors. We have previously shown that bisphenol A (BPA) accelerates the spontaneous development of diabetes in non-obese diabetic (NOD) mice. Here, we hypothesized that...article 2015
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Scholtes-Timmerman, M.J. (author), Bijlsma, S. (author), Fokkert, M.J. (author), Slingerland, R. (author), van Veen, S.J.F. (author)Self-monitoring of glucose is important for managing diabetes. Noninvasive glucose monitors are not yet available, but patients would benefit highly from such a device. We present results that may lead to a novel, point-of-care noninvasive system to measure blood glucose based on Raman spectroscopy. A hospitalized cohort of 111 subjects was...article 2014
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Simons, M. (author), Koopman, H. (author), Osinga, M. (author)Insulin requirement affects the careers of diabetic professionals who do safety-sensitive jobs. In most cases, insulin-treated individuals are automatically banned from safety-sensitive jobs because the risk of hypoglycaemia is regarded as incompatible with safety. Recent developments—such as diabetes self-management education, self-monitoring...article 2014
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Parlevliet, E.T. (author), Schröder-van der Elst, J.P. (author), Corssmit, E.P.M. (author), Picha, K. (author), O'Neil, K. (author), Stojanovic-Susulic, V. (author), Ort, T. (author), Havekes, L.M. (author), Romijn, J.A. (author), Pijl, H. (author), TNO Kwaliteit van Leven (author)CNTO736 is a glucagon-like peptide (GLP) 1 receptor agonist that incorporates a GLP-1 peptide analog linked to the Mimeti-body platform. We evaluate the potential of acute and chronic CNTO736 treatment on insulin sensitivity and very low-density lipoprotein (VLDL) metabolism. For acute studies, diet-induced insulin-resistant C57BL76 mice...article 2009
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TNO Kwaliteit van Leven (author), Wopereis, S. (author), de Rubingh, C.M. (author), van Erk, M.J. (author), Verheij, E.R. (author), van Vliet, T. (author), Cnubben, N.H. (author), Smilde, A.K. (author), van der Greef, J. (author), van Ommen, B. (author), Hendriks, H.F. (author)BACKGROUND: The prevalence of overweight is increasing globally and has become a serious health problem. Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. Novel tools to understand these processes are needed. Metabolic profiling is one such tool that can provide novel insights into...article 2009
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van den Hoek, A.M. (author), van Heijningen, C. (author), van der Schröder - Elst, J.P. (author), Ouwens, D.M. (author), Havekes, L.M. (author), Romijn, J.A. (author), Kalsbeek, A. (author), Pijl, H. (author), TNO Kwaliteit van Leven (author)OBJECTIVE-We recently showed that intracerebroventricular infusion of neuropeptide Y (NPY) hampers inhibition of endogenous glucose production (EGP) by insulin in mice. The down stream mechanisms responsible for these effects of NPY remain to be elucidated. Therefore, the aim of this study was to establish whether intracerebroventricular NPY...article 2008
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Heinen, M.M. (author), Verhage, B.A.J. (author), Lumey, L.H. (author), Brants, H.A.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Background: Recent studies of pancreatic cancer suggest a role for hyperinsulinemia in carcinogenesis. Because insulin is secreted in response to elevated blood glucose concentrations, dietary factors that increase these concentrations may be important in pancreatic carcinogenesis. Objective: The objective was to examine prospectively the...article 2008
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van den Hoek, A.M. (author), Teusink, B. (author), Voshol, P.J. (author), Havekes, L.M. (author), Romijn, J.A. (author), Pijl, H. (author), TNO Kwaliteit van Leven (author)Obese humans are often insulin- and leptin resistant. Since leptin can affect glucose metabolism, it is conceivable that a lack of leptin signal transduction contributes to insulin resistance. It remains unclear whether leptin affects glucose metabolism via peripheral and/or central mechanistic routes. In the present study, we aimed: (i) to...article 2008
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TNO Kwaliteit van Leven (author), Pasman, W.J. (author), Heimerikx, J. (author), Rubingh, C.M. (author), van den Berg, R. (author), O'Shea, M. (author), Gambelli, L. (author), Hendriks, H.F.J. (author), Einerhand, A.W.C. (author), Scott, C. (author), Keizer, H.G. (author), Mennen, L.I. (author)Appetite suppressants may be one strategy in the fight against obesity. This study evaluated whether Korean pine nut free fatty acids (FFA) and triglycerides (TG) work as an appetite suppressant. Korean pine nut FFA were evaluated in STC-1 cell culture for their ability to increase cholecystokinin (CCK-8) secretion vs. several other dietary...article 2008
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Spijkerman, A.M.W. (author), Gall, M.A. (author), Tarnow, L. (author), Twisk, J.W.R. (author), Lauritzen, E. (author), Lund-Andersen, H. (author), Emeis, J. (author), Parving, H.H. (author), Stehouwer, C.D.A. (author), TNO Kwaliteit van Leven (author)Aims: To study whether microalbuminuria, endothelial dysfunction and low-grade inflammation are associated with the presence and progression of diabetic retinopathy. Methods: Patients with Type 2 diabetes (n = 328) attending a diabetes clinic were followed for 10 years and examined annually during the last 7 years. Retinopathy was assessed after...article 2007
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van Doorn, M. (author), Vogels, J. (author), Tas, A. (author), van Hoogdalem, E.J. (author), Burggraaf, J. (author), Cohen, A. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)Aims: To explore the usefulness of metabolomics as a method to obtain a broad array of biomarkers for the pharmacological effects of rosiglitazone (RSG) in plasma and urine samples from patients with type 2 diabetes mellitus (T2DM) and healthy volunteers (HVs). Additionally, we explored the differences in metabolite concentrations between T2DM...article 2007
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Gaubius Instituut TNO (author), van den Hoek, A.M. (author), Heijboer, A.C. (author), Voshol, P.J. (author), Havekes, L.M. (author), Romijn, J.A. (author), Corssmit, E.P.M. (author), Pijl, H. (author)PYY3-36 is a gut-derived hormone acting on hypothalamic nuclei to inhibit food intake. We recently showed that PYY3-36 acutely reinforces insulin action on glucose disposal in mice. We aimed to evaluate effects of PYY3-36 on energy metabolism and the impact of chronic PYY3-36 treatment on insulin sensitivity. Mice received a single injection of...article 2007
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Blom, W.A.M. (author), Lluch, A. (author), Vinoy, S. (author), Stafleu, A. (author), van den Berg, R. (author), Holst, J.J. (author), Kok, F.J. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)Distension and chemosensitization of the stomach are insufficient to induce a ghrelin response, suggesting that postgastric feedback is required. This postgastric feedback may be regulated through insulin. We investigated the relation between gastric emptying rate and the postprandial ghrelin response as well as the role of insulin and other...article 2006
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Blom, W.A.M. (author), Lluch, A. (author), Stafleu, A. (author), Vinoy, S. (author), Holst, J.J. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)Background: The most satiating macronutrient appears to be dietary protein. Few studies have investigated the effects of dietary protein on ghrelin secretion in humans. Objective: This study was designed to investigate whether a high-protein (HP) breakfast is more satiating than a high-carbohydrate breakfast (HC) through suppression of...article 2006
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Gray, S.L. (author), Dalla Nora, E. (author), Grosse, J. (author), Manieri, M. (author), Stoeger, T. (author), Medina-Gomez, G. (author), Burling, K. (author), Wattler, S. (author), Russ, A. (author), Yeo, G.S.H. (author), Chatterjee, V.K. (author), O'Rahilly, S. (author), Voshol, P.J. (author), Cinti, S. (author), Vidal-Puig, A. (author), TNO Preventie en Gezondheid (author)Peroxisome proliferator-activated receptor (PPAR)γ is a key transcription factor facilitating fat deposition in adipose tissue through its proadipogenic and lipogenic actions. Human patients with dominant-negative mutations in PPARγ display lipodystrophy and extreme insulin resistance. For this reason it was completely unexpected that mice...article 2006
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Korsheninnikova, E. (author), van der Zon, G.C.M. (author), Voshol, P.J. (author), Janssen, G.M. (author), Havekes, L.M. (author), Grefhorst, A. (author), Kuipers, F. (author), Reijngoud, D.-J. (author), Romijn, J.A. (author), Ouwens, D.M. (author), Maassen, J.A. (author), TNO Kwaliteit van Leven (author)Aims/hypothesis: Activation of nutrient sensing through mammalian target of rapamycin (mTOR) has been linked to the pathogenesis of insulin resistance. We examined activation of mTOR-signalling in relation to insulin resistance and hepatic steatosis in mice. Materials and methods: Chronic hepatic steatosis and hepatic insulin resistance were...article 2006
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den Boer, M.A.M. (author), Voshol, P.J. (author), Schröder-van Der Elst, J.P. (author), Korsheninnikova, E. (author), Ouwens, D.M. (author), Kuipers, F. (author), Havekes, L.M. (author), Romijn, J.A. (author), TNO Kwaliteit van Leven (author)Several studies have demonstrated an association in humans between plasma levels or production capacity of the antiinflammatory cytokine IL-10 and insulin sensitivity. The aim of our study was to investigate the protective role of endogenous IL-10 availability in the development of diet-induced insulin resistance. We compared parameters of...article 2006
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den Boer, M.A.M. (author), Voshol, P.J. (author), Kuipers, F. (author), Romijn, J.A. (author), Havekes, L.M. (author), TNO Kwaliteit van Leven (author)Insulin is an important inhibitor of both hepatic glucose output and hepatic VLDL-triglyceride (VLDL-TG) production. We investigated whether both processes are equally sensitive to insulin-mediated inhibition. To test this, we used euglycemic clamp studies with four increasing plasma concentrations of insulin in wild-type C57Bl/6 mice. By...article 2006