Searched for: subject%3A%22Blood%255C%2BCoagulation%22
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TNO Preventie en Gezondheid (author), Biasucci, L.M. (author), Liuzzo, G. (author), Caligiuri, G. (author), Quaranta, G. (author), Andreotti, F. (author), Sperti, G. (author), van de Greef, W. (author), Rebuzzi, A.G. (author), Kluft, C. (author), Maseri, A. (author)
Background: Although a major role of coronary thrombosis in the pathogenesis of unstable angina has been demonstrated, the results of a series of studies have suggested that activation of the hemostatic system may not be confined to ischemic episodes. The purpose of this study was to investigate the temporal relation between ischemic episodes...
article 1996
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TNO Preventie en Gezondheid Gaubius Instituut TNO (author), Sakharov, D.V. (author), Nagelkerkel, J.F. (author), Rijken, D.C. (author)
Binding of components of the fibrinolytic system to fibrin is important for the regulation of fibrinolysis. In this study, decomposition of the fibrin network and binding of plasminogen and plasminogen activators (PAs) to fibrin during lysis of a plasma clot were investigated with confocal microscopy using fluorescein-labeled preparations of...
article 1996
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Haverkate, F. (author), Samama, M. (author), TNO Preventie en Gezondheid (author)
Approximately 250 cases of dysfibrinogenemia have been reported; 55% were asymptomatic (detected by chance), 25% had a tendency to bleeding, and 20% were reported to have a tendency to thrombosis. To establish a possible association between familial dysfibrinogenemia and thrombophilia, data on cases with both affections were collected in a study...
article 1995
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Nieuwenhuizen, W. (author), TNO Preventie en Gezondheid (author)
Fibrinogen is a large heterogeneous family of closely related molecules consisting of three pairs of non-identical polypeptide chains: two Aα-, two Bβ- and two γ-chains, held together by disulphide bridges. The heterogeneity of fibrinogen is due to heterogeneities in all three chains. Four main types of assay are used to determine fibrinogen...
article 1995
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Hennis, B.C. (author), van Boheemen, P.A. (author), Koeleman, B.P.C. (author), Boomsma, D.I. (author), Engesser, L. (author), van Wees, A.G.M. (author), Novakova, I. (author), Brommer, E.J.P. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
Recent studies describe families with both elevated plasma HRG levels and thrombosis. In order to study the possibility that allelic variants of the HRG locus are associated with differences in HRG level, we studied linkage between HRG levels and a dinucleotide repeat polymorphism in a Dutch family which was selected on the presence of both...
article 1995
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Gaubius Instituut TNO (author), Bakker, A.H.F. (author), Weening-Verhoeff, E.J.D. (author), Verheijen, J.H. (author)
To describe the role of the lysyl binding site in the interaction of tissue-type plasminogen activator (t-PA, FGK1K2P) with a forming fibrin clot, we performed binding experiments with domain deletion mutants GK1K2P, K2P, and the corresponding point mutants lacking the lysyl binding site in the absence and the presence of ε-amino caproic acid ...
article 1995
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Koopman, J. (author), Haverkate, F. (author), Grimbergen, J. (author), Lord, S.T. (author), Mosesson, M.W. (author), DiOrio, J.P. (author), Siebenlist, K.S. (author), Legrand, C. (author), Soria, J. (author), Soria, C. (author), Caen, J.P. (author), Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
The molecular defect in the abnormal fibrinogen Dusart (Paris V) that is associated with thrombophilia was determined by sequence analysis of genomic DNA that had been amplified using the polymerase chain reaction. The propositus was heterozygous for a single base change (C → T) in the Aα- chain gene, resulting in the amino acid substitution Aα...
article 1993
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Nieuwenhuizen, W. (author), Gaubius Laboratory Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Increased plasma levels of soluble fibrin are considered as molecular markers of an impending thrombotic event. Several methods to assess soluble fibrin have been in existence for many years. Most of those methods are nonspecific, semiquantitative or too laborious to be used in clinical practice. More recent methods are quantitative and...
article 1993
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Grøn, B. (author), Filion-Myklebust, C. (author), Benninck, A. (author), Nieuwenhuizen, W. (author), Matsueda, G.R. (author), Brosstad, F. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
alpha-polymer formation, as opposed to gamma-chain dimerization has been considered a relatively late event in factor XIII-induced fibrin stabilization. Recently it has been shown, however, that plasma from healthy individuals and from patients with fibrinaemia contains small amounts of soluble fibrin/fibrinogen oligomers interlinked through...
article 1992
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Emeis, J.J. (author), Gaubius Instituut TNO (author)
Chemicals/CAS: Blood Coagulation Factors; Tissue Plasminogen Activator, EC 3.4.21.68
article 1992
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de Fouw, N.J. (author), Haverkate, F. (author), Bertina, R.M. (author), Gaubius Instituut TNO (author)
The effect of purifed human activated protein C (APC) on fibrinolysis was studied by using in vitro clot lysis techniques. Clots were formed from citrated blood or plasma (supplemented with 125I-labeled fibrinogen) by adding thrombin and Ca2+-ions; lysis of the clots was achieved by the addition of tissue-type plasminogen activator before clot...
article 1991
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Engesser, L. (author), Brommer, E.J.P. (author), Kluft, C. (author), Briet, E. (author), Gaubius Instituut TNO (author)
Two hundred and three patients with venous thrombophilia were investigated in order to find out whether an elevated plasma concentration of plasminogen activator inhibitor (PAI) could be a cause of their tendency to thrombosis. The patients were studied in an asymptomatic period about 3 months after their last thromboembolic episode. PAI...
article 1989
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Brommer, E.J.P. (author), Derkx, F.H.M. (author), Schalekamp, M.A.D.H. (author), Dooijewaard, G. (author), Klaauw, V.D.M.M. (author), Gaubius instituut TNO (author)
In eight male patients with normal liver and kidney function fibrinolytic components were measured in arterial blood and in renal and hepatic vein blood, obtained during catheterization for analysis of hypertension. Blood samples were collected simultaneously from veins und corresponding arteries before and 5 minutes after the completion of...
article 1988
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Kluft, C. (author), Vellenga, E. (author), Brommer, E.J.P. (author), Wijngaards, G. (author), Gaubius instituut TNO (author)
This study concerns a case of congenital homozygous deficiency in ??2-antiplasmin associated with a severe hemorrhagic diathesis. Heterozygous family members also show a mild bleeding tendency. The propositus is a 17-yr-old male born of white parents and showing a severe hemorrhagic diathesis characterized by spontaneous bleeding in the joints...
article 1982
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Nieuwenhuizen, W. (author), Voskuilen, M. (author), Hermans, J. (author), Gaubius instituut TNO (author)
The present study was undertaken as a step to delineate further the localization of the calcium-binding sites in fibrinogen and to assess the anticlotting properties of fibrinogen degradation products. To this purpose, fragments Y were prepared by plasmin digestion of human fibrinogen in the presence of added Ca2+, and purified. We found that,...
article 1982
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Kluft, C. (author), Traas, D.W. (author), Jie, A.F.H. (author), Hoegee de Nobel, E. (author), Gaubius instituut TNO (author)
Various plasmin preparations were tested for their suitability for use in the assay of ??2-antiplasmin in blood plasma by the immediate plasmin inhibition test. Activation of plasminogen, viz., 1-Glu-plasminogen and/or 77-Lys-plasminogen, by immobilized urokinase results in plasmin preparations suitable for this ??2-antiplasmin test. Plasmins...
article 1982
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Kluft, C. (author), Michiels, J.J. (author), Wijngaards, G. (author), Gaubius instituut TNO (author)
3 patients with Behcet's disease were studied for their fibrinolytic status during exacerbation of the disease accompanied with thrombotic complications. All 3 patients exhibited low euglobulin fibrinolytic activity. This, however, could be attributed to an artificially increased coprecipitation of inhibitors, i.e., C1-inactivator in the...
article 1980
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Kluft, C. (author), Jenks, R.L. (author), Astrup, T. (author), Gaubius instituut TNO (author)
The authors studied the production of fibrinolytic activity in Hageman trait plasma, and conclude that the development of activator activity in euglobulin fractions is delayed, particularly in the Hageman trait plasma, by the presence of C1 inactivator, an inhibitor whose effect can be abolished by the synthetic compound flufenamic acid. Using...
article 1977
Searched for: subject%3A%22Blood%255C%2BCoagulation%22
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