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Bertina, R.M. (author), van Tilburg, N.H. (author), Haverkate, F. (author), Bouma, B.N. (author), von dem Borne, P.A.K. (author), Meijers, J.C.M. (author), Campbell, W. (author), Eaton, D. (author), Hendriks, D.F. (author), Willemse, J.L. (author), TNO Kwaliteit van Leven (author)CAS: blood clotting factor 11, 9013-55-2; thrombin, 9002-04-4; tissue plasminogen activator, 105913-11-9; protein C, 60202-16-6; Carboxypeptidase U, 3.4.17.20; Protein C; Tissue Plasminogen Activator, 3.4.21.68article 2006
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TNO Preventie en Gezondheid (author), Oudijk, E.J.D. (author), Nieuwenhuis, H.K. (author), Bos, R. (author), Fijnheer, R. (author)The bleeding syndrome of acute promyelocytic leukemia (APL) is complex and consists of disseminated intravascular coagulation (DIC) and hyperfibrinolysis. Elastase, derived from malignant promyelocytes, is believed to mediate the fibrinogeno- and fibrinolysis by aspecific proteolysis. In this study we measured the role of elastase in fifteen...article 2000
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Kluft, C. (author), Nieuwenhuis, H.K. (author), Rijken, D.C. (author), Groeneveld, E. (author), Wijngaards, G. (author), van Berkel, W. (author), Dooijewaard, G. (author), Sixma, J.J. (author), Gaubius instituut TNO (author)??2-Antiplasmin (??2-AP) is a major fibrinolysis inhibitor, whose complete, congenital absence has been found to be associated with a distinct hemorrhagic diathesis. We studied a 15-yr-old male with a hemorrhagic diathesis after trauma from early childhood on. This bleeding tendency was associated with a minimal ??2-AP level recorded...article 1987