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van Schalkwijk, D.B. (author), van Bochove, K. (author), van Ommen, B. (author), Freidig, A.P. (author), van Someren, E.P. (author), van der Greef, J. (author), de Graaf, A.A. (author), TNO Kwaliteit van Leven (author)This article provides methodological and technical considerations to researchers starting to develop computational model-based diagnostics using clinical chemistry data.These models are of increasing importance, since novel metabolomics and proteomics measuring technologies are able to produce large amounts of data that are difficult to...article 2010
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Chen, H. (author), Xu, X. (author), Zhu, Y. (author), TNO Kwaliteit van Leven (author)The objectives of this study were to investigate the effect of fermentation medium on the hydroxyl radical scavenging activity of exopolysaccharides from Inonotus obliquus by response surface methodology (RSM). A two-level fractional factorial design was used to evaluate the effect of different components of the medium. Corn flour, peptone, and...article 2010
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Intema, F. (author), Sniekers, Y.H. (author), Weinans, H. (author), Vianen, M.E. (author), Yocum, S.A. (author), Zuurmond, A.-M.M. (author), de Groot, J. (author), Lafeber, F.P. (author), Mastbergen, S.C. (author), TNO Kwaliteit van Leven (author)In osteoarthritis (OA), cartilage degradation is accompanied by subchondral bone changes. The pathogenesis and physiology of bone changes in OA are still unclear. The changes in subchondral bone architecture and cartilage damage were compared in differently induced experimental models of OA. Experimental OA was induced bilaterally by anterior...article 2010
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Krishnan, S. (author), Kerkhoff, H.G. (author), TNO Kwaliteit van Leven (author)A systematic approach to construct an effective multivariate test response model for capturing manufacturing defects in electronic products is described. The effectiveness of the model is demonstrated by its capability in reducing the number of test-points, while achieving the maximal coverage attainable by the specific test method on an...conference paper 2010
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van Wijk, R. (author), van der Greef, J. (author), van Wijk, E. (author), TNO Kwaliteit van Leven (author)The relationship between connective tissue and meridian function is discussed in terms of energy transmission. The network of hydrogen-bonded water molecules interspersed within the collagen fibrillar matrix is especially significant for both the sensitivity of connective tissue to weak signals of mechanical pressure, heat, or electricity and...article 2010
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Lindeman, J.H.N. (author), Ashcroft, B.A. (author), Beenakker, J.-W.M. (author), van Es, M. (author), Koekkoek, N.B.R. (author), Prins, F.A. (author), Tielemans, J.F. (author), Abdul-Hussien, H. (author), Bank, R.A. (author), Oosterkamp, T.H. (author), TNO Kwaliteit van Leven (author)An aneurysm of the aorta is a common pathology characterized by segmentalweakeningof the artery.Althoughit isgenerally accepted that the vessel-wall weakening is caused by an impaired collagen metabolism, a clear association has been demonstrated only for rare syndromes such as the vascular type Ehlers-Danlos syndrome. Here we show that vessel...article 2010
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Venema, K. (author), TNO Kwaliteit van Leven (author)Purpose of review: To describe the recent developments and insights gained in the role played by the colonic microbiota in energy and carbohydrate metabolism related to obesity in humans. Recent findings: Previous findings that the ratio of Firmicutes and Bacteriodetes is important in energy harvesting and obesity have not been confirmed in...article 2010
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Rajilić-Stojanović, M. (author), Maathuis, A. (author), Heilig, H.G.H.J. (author), Venema, K. (author), de Vos, W.M. (author), Smidt, H. (author), TNO Kwaliteit van Leven (author)A high-density phylogenetic microarray targeting small subunit rRNA (SSU rRNA) sequences of over 1000 microbial phylotypes of the human gastrointestinal tract, the HITChip, was used to assess the impact of faecal inoculum preparation and operation conditions on an in vitro model of the human large intestine (TIM-2). This revealed that...article 2010
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Moon, B.-U. (author), Koster, S. (author), Wientjes, K.J.C. (author), Kwapiszewski, R.M. (author), Schoonen, A.J.M. (author), Westerink, B.H.C. (author), Verpoorte, E. (author), TNO Kwaliteit van Leven (author)The development of continuous glucose monitoring systems is a major trend in diabetes-related research. Small, easy-to-wear systems which are robust enough to function over many days without maintenance are the goal. We present a new sensing system for continuous glucose monitoring based on a microreactor incorporating chaotic mixing channels....article 2010
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Krishnan, S. (author), Doornbos, K.D. (author), Brand, R. (author), Kerkhoff, H.G. (author), TNO Kwaliteit van Leven (author)Daily experience with product designers, test and diagnosis engineers it is realized that the depth of interaction among them, ought be high for sucessfull diagnosis of analogue circuits. With this knowledge in mind, a responsibility was undertaken to choose a popular diagnostic method and define a systematic procedure that binds together the...conference paper 2010
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van Wijk, E.P.A. (author), Wijk, R.V. (author), Bajpai, R.P. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)Photon signals emitted spontaneously from dorsal and palm sides of both hands were recorded using 6000 time windows of size T=50. ms in 50 healthy human subjects. These photon signals demonstrated universal behaviour by variance and mean. The data sets for larger time windows up to T=50. s were obtained by merging the data recorded with T=50. ms...article 2010
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den Boer, M.A.M. (author), Westerterp, M. (author), de Vries-van der Weij, J. (author), Wang, Y. (author), Hu, L. (author), Espirito Santo, S.M.S. (author), Kooistra, T. (author), Reiss, P. (author), Romijn, J.A. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)Objective: The use of the HIV-protease inhibitor ritonavir (RTV) is associated with induction of hypertriglyceridemia, which is a cardiovascular risk factor. Therefore, we investigated the effect of RTV on atherosclerosis development in APOE*3-Leiden transgenic mice, a model for human-like lipoprotein metabolism and atherosclerosis. Methods and...article 2010
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- van Deemter, M. (author), Ponsioen, T.L. (author), Bank, R.A. (author), Snabel, J.M.M. (author), van der Worp, R.J. (author), Hooymans, J.M.M. (author), Los, L.I. (author), TNO Kwaliteit van Leven (author) article 2010
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Zakrzewska, A. (author), Boorsma, A. (author), Beek, A.T. (author), Hageman, J.A. (author), Westerhuis, J.A. (author), Hellingwerf, K.J. (author), Brul, S. (author), Klis, F.M. (author), Smits, G.J. (author), TNO Kwaliteit van Leven (author)The transcriptional responses of yeast cells to a wide variety of stress conditions have been studied extensively. In addition, deletion mutant collections have been widely used to measure the combined effect of gene loss and stress on growth (fitness). Here we present a comparative analysis of 1,095 publicly available transcription and genome...article 2010
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Oudhoff, M.J. (author), Blaauboer, M.E. (author), Nazmi, K. (author), Scheres, N. (author), Bolscher, J.G.M. (author), Veerman, E.C.I. (author), TNO Kwaliteit van Leven (author)Antimicrobial peptides are multifunctional in innate immunity and wound repair of multicellular organisms. We were the first to discover that histatins, a family of salivary antimicrobial peptides, enhance epithelial cell migration, suggesting a role in oral wound healing. It is unknown whether histatins display innate-immunity activities,...article 2010
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Balvers, M.G.J. (author), Verhoeckx, K.C.M. (author), Plastina, P. (author), Wortelboer, H.M. (author), Meijerink, J. (author), Witkamp, R.F. (author), TNO Kwaliteit van Leven (author)n-3 PUFAs have beneficial health effects which are believed to be partly related to their anti-inflammatory properties, however the exact mechanisms behind this are unknown. One possible explanation could be via their conversion to N-acyl ethanolamines (NAEs), which are known to possess anti-inflammatory properties. Using fatty acid precursors...article 2010
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Mulder, S.D. (author), van der Flier, W.M. (author), Verheijen, J.H. (author), Mulder, C. (author), Scheltens, P. (author), Blankenstein, M.A. (author), Hack, C.E. (author), Veerhuis, R. (author), TNO Kwaliteit van Leven (author)Several studies have shown that reduced amyloid-β 1-42 (Aβ {42}) and increased tau levels in cerebrospinal fluid (CSF) reflect increased Alzheimer's disease (AD) pathology in the brain. β-site APP cleaving enzyme (BACE1) is thought to be the major β-secretase involved in Aβ production in the brain, and therefore we investigated the relation...article 2010
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Heinen, M.M. (author), Verhage, B.A.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Background: To date, cigarette smoking is the most consistent risk factor for pancreatic cancer. We prospectively examined the role of active cigarette smoking, smoking cessation, and passive smoking as determinants for pancreatic cancer. Methods: The Netherlands Cohort Study consisted of 120,852 men and women who completed a baseline...article 2010
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Vlaanderen, J. (author), Fransman, W. (author), Miller, B. (author), Burstyn, I. (author), Heederik, D. (author), Hurley, F. (author), Vermeulen, R. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)Introduction: In occupational epidemiology, differences in the temporal coverage of the exposure history by available exposure measurement data may affect the uncertainty of exposure estimates. In the reporting of results of studies, greater attention should be paid to the extent to which exposure assessments require extrapolation outside the...article 2010
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van den Berg, S.A.A. (author), Nabben, M. (author), Bijland, S. (author), Voshol, P.J. (author), van Klinken, J.B. (author), Havekes, L.M. (author), Romijn, J.A. (author), Hoeks, J. (author), Hesselink, M.K. (author), Schrauwen, P. (author), van Dijk, K.W. (author), TNO Kwaliteit van Leven (author)Considerable variation in energy expenditure is observed in C57Bl/6 mice on a high-fat diet. Because muscle tissue is a major determinant of whole-body energy expenditure, we set out to determine the variation in energy expenditure and its possible association with skeletal muscle mitochondrial function upon high-fat diet intervention. Metabolic...article 2010