Searched for: subject:"Biomarkers"
(1 - 20 of 79)

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vn den Bloem, R. Brink, W. (author), Ananth, A. (author), Kanagasabapathi, T. (author), Amelink, A. (author), Bouwman, J. (author), Gelinck, G. (author), van Veen, S. (author), Boorsma, A. (author), Wopereis, S. (author)
Health maintenance and disease prevention strategies become increasingly prioritized with increasing health and economic burden of chronic, lifestyle-related diseases. A key element in these strategies is the empowerment of individuals to control their health. Self-measurement plays an essential role in achieving such empowerment. Digital...
article 2021
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Kallen, V. (author), Tahir, M. (author), Bedard A., (author), Bongers, B. (author), van Riel, N. (author), van Meeteren, N. (author)
Allostatic load reflects the cumulative strain on organic functions that may gradually evolve into overt disease. Our aim was to evaluate the allostatic parameters in the context of aging, and identify the parameters that may be suitable for an allostatic load index for elderly people (>60 years). From previously published studies, 11 allostatic...
article 2021
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Smits, M. (author), Meijerink, M. (author), Le, T.M. (author), Knulst, A. (author), de Jong, A. (author), Caspers, M.P.M. (author), Lima, E.S. (author), Babe, L. (author), Ladics, G. (author), McClain, S. (author), Houben, G.F. (author), Verhoeckx, K. (author)
Background: Food proteins differ in their allergenic potential. Currently, there is no predictive and validated bio-assay to evaluate the allergenicity of novel food proteins. The objective of this study was to investigate the potential of a human peripheral blood mononuclear cell (PBMC) gene expression assay to identify biomarkers to predict...
article 2021
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Hemme, M. (author), Fidder, A. (author), van der Riet-van Oeveren, D. (author), van der Schans, M.J. (author), Noort, D. (author)
The primary aim of this study was to identify biomarkers of exposure to some so-called Schedule 1 sulfur mustard (HD) analogues, in order to facilitate and expedite their retrospective analysis in case of alleged use of such compounds. Since these HD analogues can be regarded as model compounds for possible impurities of HD formed during...
article 2021
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Kim, Y. (author), Kim, Y. (author), Hwang, J. (author), van den Broek, T.J. (author), Oh, B. (author), Kim, J.Y. (author), Wopereis, S. (author), Bouwman, J. (author), Kwon, O. (author)
Oxidative stress aggravates the progression of lifestyle-related chronic diseases. However, knowledge and practices that enable quantifying oxidative stress are still lacking. Here, we performed a proof-of-concept study to predict the oxidative stress status in a healthy population using retrospective cohort data from Boramae medical center in...
article 2021
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Bongers, C.C.W.G. (author), ten Haaf, D.S.M. (author), Catoire, M. (author), Kersten, B. (author), Wouters, J.A. (author), Eijsvogels, T.M.H. (author), Hopman, M.T.E. (author)
The purpose of this study was to examine the effects of 12 weeks collagen peptide (CP) supplementation on knee pain and function in individuals with self-reported knee pain. Healthy physically active individuals (n = 167, aged 63 [interquartile range = 56-68] years) with self-reported knee pain received 10 g/day of CP or placebo for 12 weeks....
article 2020
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Scholten, B. (author), Vlaanderen, J. (author), Stierum, R. (author), Portengen, L. (author), Rothman, N. (author), Lan, Q. (author), Pronk, A. (author), Vermeulen, R. (author)
BACKGROUND: The genotoxicity of benzene has been investigated in dozens of biomonitoring studies, mainly by studying (classical) chromosomal aberrations (CAs) or micronuclei (MN) as markers of DNA damage. Both have been shown to be predictive of future cancer risk in cohort studies and could, therefore, potentially be used for risk assessment of...
article 2020
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Scholten, B. (author), Laura Kenny, L. (author), Duca, R.C. (author), Pronk, A. (author), Santonen, T. (author), Galea, K.S. (author), Loh, M. (author), Huumonen, K. (author), Sleeuwenhoek, A. (author), Creta, M. (author), Godderis, L. (author), Jones, K. (author)
Diisocyanates are a group of chemicals that are widely used in occupational settings. They are known to induce various health effects, including skin- and respiratory tract sensitization resulting in allergic dermatitis and asthma. Exposure to diisocyanates has been studied in the past decades by using different types of biomonitoring markers...
article 2020
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Castan, L. (author), Bøgh, K.L. (author), Maryniak, N.Z. (author), Epstein, M.M. (author), Sahar Kazemi, S. (author), O'Mahony, L. (author), Bodinier, M. (author), Smit, J.J. (author), van Bilsen, J.H.M. (author), Blanchard, C. (author), Głogowski, R. (author), Kozáková, H. (author), Schwarzer, M. (author), Noti, M. (author), de Wit, N. (author), Bouchaud, G. (author), Bastiaan-Net, S. (author)
Significant efforts are necessary to introduce new dietary protein sources to feed a growing world population while maintaining food supply chain sustainability. Such a sustainable protein transition includes the use of highly modified proteins from side streams or the introduction of new protein sources that may lead to increased clinically...
article 2020
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Hoevenaars, F.P.M. (author), van der Kamp, J.W. (author), van den Brink, W.D. (author), Wopereis, S. (author)
Health claims on foods are a way of informing consumers about the health benefits of a food product. Traditionally, these claims are based on scientific evaluation of markers originating from a pharmacological view on health. About a decade ago, the definition of health has been rephrased to ‘the ability to adapt’ that opened up the possibility...
article 2020
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van Bilsen, J.H.M. (author), Dulos, R. (author), van Stee, M.F. (author), Meima, M.Y. (author), Rouhani Rankouhi, T. (author), Neergaard Jacobsen, L. (author), Staudt Kvistgaard, A. (author), Garthoff, J.A. (author), Knippels, L.M.J. (author), Knipping, K. (author), Houben, G.F. (author), Verschuren, L. (author), Meijerink, M. (author), Krishnan, S. (author)
A healthy immune status is strongly conditioned during early life stages. Insights into the molecular drivers of early life immune development and function are prerequisite to identify strategies to enhance immune health. Even though several starting points for targeted immune modulation have been identified and are being developed into...
article 2020
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Stevens, L.J. (author), Donkers, J.M. (author), Dubbel, J. (author), Vaes, W.H.J. (author), van de Steeg, E. (author), Knibbe, C.A.J. (author), Alwayn, I.P.J. (author), van de Steeg, E. (author)
To predict the absorption, distribution, metabolism and excretion (ADME) profile of candidate drugs a variety of preclinical models can be applied. The ADME and toxicological behavior of newly developed drugs are often investigated prior to assessment in humans, which is associated with long time-lines and high costs. Therefore, good predictions...
article 2020
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van den Dries, M.A. (author), Guxens, M. (author), Pronk, A. (author), Spaan, S. (author), El Marroun, H. (author), Jusko, T.A. (author), Longnecker, M.P. (author), Ferguson, K.K. (author), Tiemeier, H. (author)
Background: Prenatal exposure to organophosphate (OP) pesticides has been associated with altered neuronal cell development and behavioral changes in animal offspring. However, the few studies investigating the association between prenatal OP pesticide exposure and neurodevelopmental outcomes such as Attention-Deficit Hyperactivity Disorder ...
article 2019
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Oerlemans, A. (author), Verscheijden, L.F.M. (author), Mol, J.G.J. (author), Vermeulen, R.C.H. (author), Westerhout, J. (author), Roeleveld, N. (author), Russel, F.G.M. (author), Scheepers, P.T.J. (author)
Tebuconazole (TEB) is a widely used triazole fungicide, but the toxicokinetics of its human metabolites are not fully described. For proper interpretation of biological monitoring data, knowledge on the metabolism and elimination of the compound is required. A human volunteer study was performed with the aim to describe the time courses of...
article 2019
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Tans, R. (author), Verschuren, L. (author), Wessels, H.J.C.T. (author), Bakker, S.J.L. (author), Tack, C.J. (author), Gloerich, J. (author), van Gool, A.J. (author)
Introduction: The onset of type 2 diabetes mellitus (T2DM) is strongly associated with obesity and subsequent perturbations in immuno-metabolic responses. To understand the complexity of these systemic changes and better monitor the health status of people at risk, validated clinical biomarkers are needed. Omics technologies are increasingly...
article 2019
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Hoevenaars, F.P.M. (author), Esser, D. (author), Schutte, S. (author), Priebe, M.G. (author), Vonk, R.J. (author), van den Brink, W.J. (author), van der Kamp, J.W. (author), Stroeve, J.H.M. (author), Afman, L.A. (author), Wopereis, S. (author)
Background. Whole grain wheat (WGW) consumption is associated with health benefits in observational studies. However, WGW randomized controlled trial (RCT) studies show mixed effects. Objectives. The health impact of WGW consumption was investigated by quantification of the body's resilience, which was defined as the “ability to adapt to a...
article 2019
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Tans, R. (author), van Diepen, J.A. (author), Bijlsma, S. (author), Verschuren, L. (author), Suppers, A. (author), Stienstra, R. (author), Wevers, R.A. (author), Tack, C.J. (author), Gloerich, J. (author), van Gool, A.J. (author)
Background: Overweight and obesity can lead to adipose tissue inflammation, which causes insulin resistance and on the long-term type 2 diabetes mellitus (T2D). The inflammatory changes of obese-adipose tissue are characterized by macrophage infiltration and activation, but validated circulating biomarkers for adipose tissue inflammation for...
article 2019
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Fallaize, R. (author), Livingstone, K.M. (author), Celis-Morales, C. (author), Macready, A.L. (author), San-Cristobal, R. (author), Navas-Carretero, S. (author), Marsaux, C.F.M. (author), O’Donovan, C.B. (author), Kolossa, S. (author), Moschonis, G. (author), Walsh, M.C. (author), Gibney, E.R. (author), Brennan, L. (author), Bouwman, J. (author), Manios, Y. (author), Jarosz, M. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gundersen, T.E. (author), Drevon, C.A. (author), Gibney, M.J. (author), Mathers, J.C. (author), Lovegrove, J.A. (author)
Diet-quality scores (DQS), which are developed across the globe, are used to define adherence to specific eating patterns and have been associated with risk of coronary heart disease and type-II diabetes. We explored the association between five diet-quality scores (Healthy Eating Index, HEI; Alternate Healthy Eating Index, AHEI; MedDietScore,...
article 2018
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Vitali, F. (author), Lombardo, R. (author), Rivero, D. (author), Mattivi, F. (author), Franceschi, P. (author), Bordoni, A. (author), Trimigno, A. (author), Capozzi, F. (author), Felici, G. (author), Taglino, F. (author), Miglietta, F. (author), de Cock, N. (author), Lachat, C. (author), de Baets, B. (author), de Tré, G. (author), Pinart, M. (author), Nimptsch, K. (author), Pischon, T. (author), Bouwman, J. (author), Cavalieri, D. (author)
Background: The multidisciplinary nature of nutrition research is one of its main strengths. At the same time, however, it presents a major obstacle to integrate data analysis, especially for the terminological and semantic interpretations that specific research fields or communities are used to. To date, a proper ontology to structure and...
article 2018
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Steckling, N. (author), Gotti, A. (author), Bose-O'Reilly, S. (author), Chapizanis, D. (author), Costopoulou, D. (author), de Vocht, F. (author), Garí, M. (author), Grimalt, J.O. (author), Heath, E. (author), Hiscock, R. (author), Jagodic, M. (author), Karakitsios, S.P. (author), Kedikoglou, K. (author), Kosjek, T. (author), Leondiadis, L. (author), Maggos, T. (author), Mazej, D. (author), Polańska, K. (author), Povey, A. (author), Rovira, J. (author), Schoierer, J. (author), Schuhmacher, M. (author), Špirić, Z. (author), Stajnko, A. (author), Stierum, R. (author), Tratnik, J.S. (author), Vassiliadou, I. (author), Annesi-Maesano, I. (author), Horvat, M. (author), Sarigiannis, D.A. (author)
Background: The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys – aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all...
article 2018
Searched for: subject:"Biomarkers"
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