Searched for: subject:"Biology%5C+Health"
(1 - 20 of 32)

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Bouwman, J. (author), Vogels, J.T.W.E. (author), Wopereis, S. (author), Rubingh, C.M. (author), Bijlsma, S. (author), van Ommen, B. (author)
Background: Being able to visualize multivariate biological treatment effects can be insightful. However the axes in visualizations are often solely defined by variation and thus have no biological meaning. This makes the effects of treatment difficult to interpret. Methods: A statistical visualization method is presented, which analyses and...
article 2012
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Sivana, S.S. (author), van El, B. (author), Merkher, Y. (author), Schmelzer, C.E.H. (author), Zuurmond, A.M. (author), Heinz, A. (author), Wachtel, E. (author), Varga, P.P. (author), Lazary, A. (author), Brayda-Bruno, M. (author), Maroudas, A. (author)
Background Aging and degeneration of human intervertebral disc (IVD) are associated with biochemical changes, including racemization and glycation. These changes can only be counteracted by protein turnover. Little is known about the longevity of IVD elastin in health or disease. Yet, such knowledge is important for a quantitative understanding...
article 2012
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Meijerink, M. (author), Wells, J. (author), Taverne, N. (author), de Zeeuw Brouwer, M.L. (author), Hilhorst, B. (author), Venema, K. (author), van Bilsen, J. (author)
Peanut allergy accounts for the majority of severe food-related allergic reactions and there is a need for new prevention and treatment strategies. Probiotics may be considered for treatment on the basis of their immunomodulating properties. Cytokine profiles of probiotic strains were determined by in vitro co-culture with human PBMCs. Three...
article 2012
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Balvers, M.G.J. (author), Verhoeckx, K.C.M. (author), Meijerink, J. (author), Bijlsma, S. (author), Rubingh, C.M. (author), Wortelboer, H.M. (author), Witkamp, R.F. (author)
Eicosanoids and endocannabinoids/N-acylethanolamines (NAEs) are fatty acid derived compounds with a regulatory role in inflammation. Considering their complex metabolism, it is likely that inflammation affects multiple compounds at the same time, but how lipid profiles change in plasma and other tissues after an inflammatory stimulus has not...
article 2012
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Coulier, L. (author), Muilwijk, B. (author), Bijlsma, S. (author), Noga, M. (author), Tienstra, M. (author), Attali, A. (author), van Aken, H. (author), Suidgeest, E. (author), Tuinstra, T. (author), Hankemeier, T. (author), Bobeldijk, I. (author)
Analysis of metabolites in biofluids by gas chromatography–mass spectrometry (GC–MS) after oximation and silylation is a key method in metabolomics. The GC–MS method was modified by a modified vial design and sample work-up procedure in order to make the method applicable to small volumes of cerebrospinal fluid (CSF), i.e. 10 μL, with similar...
article 2012
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Bates, A.E. (author), Harme, T.L. (author), Roeselers, G. (author), Cavanaugh, C.M. (author)
Marine invertebrates hosting chemosynthetic bacterial symbionts are known from multiple phyla and represent remarkable diversity in form and function. The deep-sea hydrothermal vent limpet Lepetodrilus fucensis from the Juan de Fuca Ridge complex hosts a gill symbiosis of particular interest because it displays a morphology unique among molluscs...
article 2011
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Joosten, M.M. (author), Balvers, M.G.J. (author), Verhoeckx, K.C.M. (author), Hendriks, H.F.J. (author), Witkamp, R.F. (author), TNO Kwaliteit van Leven (author)
N-acylethanolamines (NAEs), such as anandamide (AEA), are a group of endogenous lipids derived from a fatty acid linked to ethanolamine and have a wide range of biological activities, including regulation of metabolism and food intake. We hypothesized that i) NAE plasma levels are associated with levels of total free fatty acids (FFAs) and their...
article 2010
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Jacobs, J.F. (author), Punt, C.J. (author), Lesterhuis, W.J. (author), Sutmuller, R.P. (author), Brouwer, H.M. (author), Scharenborg, N.M. (author), Klasen, I.S. (author), Hilbrands, L.B. (author), Figdor, C.G. (author), de Vries, I.J. (author), Adema, G.J. (author), TNO Kwaliteit van Leven (author)
Purpose: The success of cancer immunotherapy depends on the balance between effector T cells and suppressive immune regulatory mechanisms within the tumor microenvironment. In this study we investigated whether transient monoclonal antibody–mediated depletion of CD25high regulatory T cells (Treg) is capable of enhancing the immunostimulatory...
article 2010
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Roeselers, G. (author), Guss, A.M. (author), Newton, I.L.G. (author), Klepac-Ceraj, V. (author), Lory, S. (author), Cavanaugh, C.M. (author), TNO Kwaliteit van Leven (author)
In patients afflicted with cystic fibrosis (CF), morbidity and mortality are primarily associated with the adverse consequences of chronic microbial bronchial infections, which are thought to be caused by a few opportunistic pathogens. However, recent evidence suggests the presence of other microorganisms, which may significantly affect the...
article 2010
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Gubbels, J.S. (author), Kremers, S.P.J. (author), Stafleu, A. (author), Dagnelie, P.C. (author), de Vries, S.I. (author), de Vries, N.K. (author), Thijs, C. (author), TNO Kwaliteit van Leven (author)
Objective: To examine clustering of energy balance-related behaviors (EBRBs) in young children. This is crucial because lifestyle habits are formed at an early age and track in later life. This study is the first to examine EBRB clustering in children as young as 2 years. Study design: Cross-sectional data originated from the Child, Parent and...
article 2009
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Verschuren, L. (author), Kooistra, T. (author), Bernhagen, J. (author), Voshol, P. (author), Ouwens, D.M. (author), van Erk, M. (author), de Vries-van der Weij, J. (author), Leng, L. (author), van Bockel, J.H. (author), Willems van Dijkl, K. (author), Fingerle-Rowson, G. (author), Bucala, R. (author), Kleemann, R. (author), TNO Kwaliteit van Leven (author)
Chronic inflammation in white adipose tissue (WAT) is positively associated with obesity, insulin resistance (IR) and the development of type 2 diabetes. The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is an essential, upstream component of the inflammatory cascade. This study examines whether MIF is required for the...
article 2009
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Hu, C. (author), van der Heijden, R. (author), Wang, M. (author), van der Greef, J. (author), Hankemeier, T. (author), Xu, G. (author), TNO Kwaliteit van Leven (author)
Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes...
article 2009
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Appeldoorn, M.M. (author), Venema, D.P. (author), Peters, T.H.F. (author), Koenen, M.E. (author), Arts, I.C.W. (author), Vincken, J.-P. (author), Gruppen, H. (author), Keuer, J. (author), Hollman, P.C.H. (author), TNO Kwaliteit van Leven (author)
The vasorelaxing properties of chocolate and wine might relate to the presence of phenolic compounds. One of the potential mechanisms involved is stimulation of endothelial nitric oxide (NO) production, as NO is a major regulator of vasodilatation. This study aimed to develop an in vitro assay using the hybrid human endothelial cell line EA...
article 2009
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Boesten, L.S.M. (author), Zadelaar, A.S.M. (author), van Nieuwkoop, A. (author), Hu, L. (author), Teunisse, A.F.A.S. (author), Jochemsen, A.G. (author), Evers, B. (author), van de Water, B. (author), Gijbels, M.J.J. (author), van Vlijmen, B.J.M. (author), Havekes, L.M. (author), de Winther, M.P.J. (author), TNO Kwaliteit van Leven (author)
The cellular composition of atherosclerotic lesions is determined by many factors including cell infiltration, proliferation and cell death. Tumor suppressor gene p53 has been shown to regulate both cell proliferation and cell death in many cell types. In the present study, we investigated the role of macrophage p53 in the pathogenesis of early...
article 2009
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Hamer, H.M. (author), Jonkers, D.M.A.E. (author), Loof, A. (author), van Houtvin, S.A.L.W. (author), Troost, F.J. (author), Venema, K. (author), Kodde, A. (author), Koek, G.H. (author), Schipper, R.G. (author), van Heerde, W.L. (author), Brummer, R.J. (author), TNO Kwaliteit van Leven (author)
Background: The mucus layer is an important dynamic component of the epithelial barrier. It contains mucin glycoproteins and other compounds secreted by the intestinal epithelium, such as secretory IgA. However, a standardized in vivo sampling technique of mucus in humans is not yet available. Aim: To assess the validity and feasibility of mucin...
article 2009
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Geert Heidema, A. (author), Thissen, U. (author), Boer, J.M.A. (author), Bouwman, F.G. (author), Feskens, E.J.M. (author), Mariman, E.C.M. (author), TNO Kwaliteit van Leven (author)
In this study, we applied the multivariate statistical tool Partial Least Squares (PLS) to analyze the relative importance of 83 plasma proteins in relation to coronary heart disease (CHD) mortality and the intermediate end points body mass index, HDL-cholesterol and total cholesterol. From a Dutch monitoring project for cardiovascular disease...
article 2009
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Hamer, H.M. (author), Jonkers, D.M.A.E. (author), Bast, A. (author), Vanhoutvin, S.A.L.W. (author), Fischer, M.A.J.G. (author), Kodde, A. (author), Troost, F.J. (author), Venema, K. (author), Brummer, R.J.M. (author), TNO Kwaliteit van Leven (author)
article 2009
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de Jong, Z. (author), Munneke, M. (author), Vilim, V. (author), Zwinderman, A.H. (author), Kroon, H.M. (author), Ronday, H.K. (author), Lems, W.F. (author), Dijkmans, B.A.C. (author), Breedveld, F.C. (author), Vliet Vlieland, T.P.M. (author), Hazes, J.M.W. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)
Objective. To investigate the utility of serum COMP level measurements as a predictor of future damage of the weight-bearing (large) joints in RA patients participating in intensive exercise. Methods. Data of the 281 completers of a 2-yr randomized controlled trial (Rheumatoid Arthritis Patients In Training; RAPIT) comparing the effects of usual...
article 2008
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Smeets, P.A.M. (author), de Graaf, C. (author), Stafleu, A. (author), van Osch, M.J.P. (author), van der Grond, J. (author), TNO Kwaliteit van Leven (author)
The hypothalamus is intimately involved in the regulation of food intake, integrating multiple neural and hormonal signals. Several hypothalamic nuclei contain glucose-sensitive neurons, which play a crucial role in energy homeostasis. Although a few functional magnetic resonance imaging (fMRI) studies have indicated that glucose consumption has...
article 2005
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Monraats, P.S. (author), Pires, N.M.M. (author), Schepers, A. (author), Agema, W.R.P. (author), Boesten, L.S.M. (author), de Vries, M.R. (author), Zwinderman, A.H. (author), de Maat, M.P.M. (author), Doevendans, P.A.F.M. (author), de Winter, R.J. (author), Tio, R.A. (author), Waltenberger, J. (author), 't Hart, L.M. (author), Frants, R.R. (author), Quax, P.H.A. (author), van Vlijmen, B.J.M. (author), Havekes, L.M. (author), van der Laarse, A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), TNO Kwaliteit van Leven (author)
Genetic factors appear to be important in the restenotic process after percutaneous coronary intervention (PCI), as well as in inflammation, a pivotal factor in restenosis. TNFα, a key regulator of inflammatory responses, may exert critical influence on the development of restenosis after PCI. The GENetic DEterminants of Restenosis (GENDER)...
article 2005
Searched for: subject:"Biology%5C+Health"
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