Searched for: subject:"Biology"
(1 - 20 of 3,089)

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Deksren, G.C.H. (author), Holthoon, F.L. (author), Willemen, H.M. (author), Krul, C.A.M. (author), Franssen, M.C.R. (author), van Beek, T.A. (author)
Madder, used as a red dye, contains anthraquinones, and some of these can react with DNA possibly causing mutagenic effects. This is especially true for 1,3-dihydroxyanthraquinones with a hydroxymethyl (e.g., lucidin 6, ibericin 10) or methyl group (e.g., rubiadin 9) at C-2. In this research, a new process was developed through which the...
article 2021
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de Hoogh, I.M. (author), Winters, B.L. (author), Nieman, K.M. (author), Bijlsma, S. (author), Krone, T. (author), van den Broek, T.J. (author), Anderson, B.D. (author), Caspers, M.P.M. (author), Anthony, J.C. (author), Wopereis, S. (author)
Personalized nutrition may be more effective in changing lifestyle behaviors compared to population-based guidelines. This single-arm exploratory study evaluated the impact of a 10-week personalized systems nutrition (PSN) program on lifestyle behavior and health outcomes. Healthy men and women (n = 82) completed the trial. Individuals were...
article 2021
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Summer, G. (author), Kuhn, A.R. (author), Munts, C. (author), Miranda-Silva, D. (author), Leite-Moreira, A.F. (author), Lourenço, A.P. (author), Heymans, S. (author), Falcão-Pires, I. (author), van Bilsen, M. (author)
Aims: The metabolic syndrome and associated comorbidities, like diabetes, hypertension and obesity, have been implicated in the development of heart failure with preserved ejection fraction (HFpEF). The molecular mechanisms underlying the development of HFpEF remain to be elucidated. We developed a cardiome-directed network analysis and applied...
article 2020
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Adams, S.H. (author), Anthony, J.C. (author), Carvajal, R. (author), Chae, L. (author), Khoo, C.S.H. (author), Latulippe, M.E. (author), Matusheski, N.V. (author), McClung, H.L. (author), Rozga, M. (author), Schmid, C.H. (author), Wopereis, S. (author), Yan, W. (author)
Personalized nutrition (PN) approaches have been shown to help drive behavior change and positively influence health outcomes. This has led to an increase in the development of commercially available PN programs, which utilize various forms of individual-level information to provide services and products for consumers. The lack of a well...
article 2020
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Kuper, C.F. (author), Bosland, M.C. (author)
article 2019
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Vreeken, D. (author), Wiesmann, M. (author), Deden, L.N. (author), Arnoldussen, I.A.C. (author), Aarts, E. (author), Kessels, R.P.C. (author), Kleemann, R. (author), Hazebroek, E.J. (author), Aarts, E.O. (author), Kiliaan, A.J. (author)
Introduction Weight loss after bariatric surgery (BS) is often associated with improved cognition and structural brain recovery. However, improved cognition after BS is not always exhibited by patients, in fact, in some cases there is even a decline in cognition. Long-term consequences of BS weight loss, in terms of obesity and related diseases,...
article 2019
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Hogenelst, K. (author), Soeter, M. (author), Kallen, V. (author)
Accumulating evidence supports the harmful effects of stress on health, including the development and progress of psychopathology (e.g. anxiety disorders), metabolic disorders (e.g. diabetes type II), inflammatory disturbances, and cardiovascular disease. These harmful effects are often expressed as disturbances in cortisol levels, patterns, or...
article 2019
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Pali-Scholl, I. (author), Blank, S. (author), Verhoeckx, K. (author), Mueller, R.S. (author), Janda, J. (author), Marti, E. (author), Seida, A.A. (author), Rhyner, C. (author), DeBoer, D.J. (author), Jensen-Jarolim, E. (author)
Adverse reactions to insects occur in both human and veterinary patients. Systematic comparison may lead to improved recommendations for prevention and treatment in all species. In this position paper, we summarize the current knowledge on insect allergy induced via stings, bites, inhalation or ingestion, and compare reactions in companion...
article 2019
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Kubbinga, M. (author), Augustijns, P. (author), Garcia, M.A. (author), Heinen, C. (author), Wortelboer, H.M. (author), Verwei, M. (author), Langguth, P. (author)
Chitosan is object of pharmaceutical research as a candidate permeability enhancer. However, chitosan was recently shown to reduce the oral bioavailability of acyclovir in humans. The effect of chitosan on two processes determining the oral bioavailability of acyclovir, bioaccessibility and intestinal absorption, was now investigated. Acyclovir...
article 2019
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Butler, J. (author), Hens, B. (author), Vertzoni, M. (author), Brouwers, J. (author), Berben, P. (author), Dressman, J. (author), Andreas, C.J. (author), Schaefer, K.J. (author), Mann, J. (author), McAllister, M. (author), Jamei, M. (author), Kostewicz, E. (author), Kesisoglou, F. (author), Langguth, P. (author), Minekus, M. (author), Müllertz, A. (author), Schilderink, R. (author), Koziolek, M. (author), Jedamzik, P. (author), Weitschies, W. (author), Reppas, C. (author), Augustijns, P. (author)
The availability of in vitro tools that are constructed on the basis of a detailed knowledge of key aspects of gastrointestinal (GI) physiology and their impact on formulation performance and subsequent drug release behaviour is fundamental to the success and efficiency of oral drug product development. Over the last six years, the development...
article 2019
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Mirahmadi, F. (author), Koolstra, J.H. (author), Fazaeli, S. (author), Lobbezoo, F. (author), van Lenthe, G.H. (author), Snabel, J. (author), Stoop, R. (author), Everts, V. (author)
Nutrition of articular cartilage relies mainly on diffusion and convection of solutes through the interstitial fluid due to the lack of blood vessels. The diffusion is controlled by two factors: steric hindrance and electrostatic interactions between the solutes and the matrix components. Aging comes with changes in the cartilage structure and...
article 2019
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Agamennone, V. (author), van Straalen, J. (author), Brouwer, A. (author), de Boer, T.E. (author), Hensbergen, P.J. (author), Zaagman, N. (author), Braster, M. (author), van Straalen, N.M. (author), Roelofs, D. (author), Janssens, T.K.S. (author)
Antibiotic resistance necessitates the search for new bioactive compounds with novel mechanisms of action. Natural products derived from bacteria and fungi are widely used in the field of medicine and new environments can be explored as sources of antimicrobials. Bacteria associated with springtails have shown high inhibitory activity against...
article 2019
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Gart, E. (author), Souto Lima, E. (author), Schuren, F. (author), de Ruiter, C.G.F. (author), Attema, J. (author), Verschuren, L. (author), Keijer, J. (author), Salic, K. (author), Morrison, M.C. (author), Kleemann, R. (author)
Development of non-alcoholic fatty liver disease (NAFLD) is linked to obesity, adipose tissue inflammation, and gut dysfunction, all of which depend on diet. So far, studies have mainly focused on diet-related fecal microbiota changes, but other compartments may be more informative on host health. We present a first systematic analysis of...
article 2019
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Erpelinck, E. (author), Meijers, T. (author), Ariga, K. (author)
The TNO InTESTine™ system is developed to study the absorption and translocation of pharmaceutical, biological and nutritional compounds across the intestinal wall in a physiologically relevant model. In this medium-throughput system, fresh ex vivo intestinal tissue from human or animal origin is mounted into a two compartment model with an...
other 2019
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He, M. (author), Harms, A.C. (author), van Wijk, E. (author), Wang, M. (author), Berger, R. (author), Koval, S. (author), Hankemeier, T. (author), van der Greef, J. (author)
Background. Rheumatoid arthritis (RA) is a complex, chronic autoimmune disease characterized by various inflammatory symptoms, including joint swelling, joint pain, and both structural and functional joint damage. The most commonly used animal model for studying RA is mice with collagen‐induced arthritis (CIA); the wide use of this model is due...
article 2019
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Tans, R. (author), Verschuren, L. (author), Wessels, H.J.C.T. (author), Bakker, S.J.L. (author), Tack, C.J. (author), Gloerich, J. (author), van Gool, A.J. (author)
Introduction: The onset of type 2 diabetes mellitus (T2DM) is strongly associated with obesity and subsequent perturbations in immuno-metabolic responses. To understand the complexity of these systemic changes and better monitor the health status of people at risk, validated clinical biomarkers are needed. Omics technologies are increasingly...
article 2019
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Agamennone, V. (author), Krul, C.A.M. (author), Rijkers, G. (author), Kort, R. (author)
BACKGROUND Antibiotic-associated diarrhea (AAD) is a side-effect frequently associated with the use of broad spectrum antibiotics. Although a number of clinical studies show that co-administration of specific probiotics reduces the risk for AAD, there is still unclarity among healthcare professionals on the recommendation of probiotic products....
article 2019
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Meijerink, M. (author), van den Broek, T. (author), Dulos, R. (author), Neergaard Jacobsen, L. (author), Kvistgaard, A. Staudt (author), Garthoff, J. (author), Knippels, L. (author), Knipping, K. (author), Houben, G. (author), Verschuren, L. (author), van Bilsen, J. (author)
Despite scientific advances it remains difficult to predict the risk and benefit balance of immune interventions. Since a few years, network models have been built based on comprehensive datasets at multiple molecular/cellular levels (genes, gene products, metabolic intermediates, macromolecules, cells) to illuminate functional and structural...
article 2019
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Meijerink, M. (author), van den Broek, T.J. (author), Dulos, R. (author), Garthoff, J. (author), Knippels, L. (author), Knipping, K. (author), Harthoorn, L. (author), Houben, G. (author), Verschuren, L. (author), van Bilsen, J. (author)
To assess the safety and efficacy of oral immune interventions, it is important and required by regulation to assess the impact of those interventions not only on the immune system, but also on other organs such as the gut as the porte d'entrée. Despite clear indications that the immune system interacts with several physiological functions of...
article 2019
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Wilkinson, M.D. (author), Dumontier, M. (author), Aalbersberg, I.J. (author), Appleton, G. (author), Axton, M. (author), Baak, A. (author), Blomberg, N. (author), Boiten, J.W. (author), da Silva Santos, L.B. (author), Bourne, P.E. (author), Bouwman, J. (author), Brookes, A.J. (author), Clark, T. (author), Crosas, M. (author), Dillo, I. (author), Dumon, O. (author), Edmunds, S. (author), Evelo, C.T. (author), Finkers, R. (author), Gonzalez-Beltran, A. (author), Gray, A.J.G. (author), Groth, P. (author), Goble, C. (author), Grethe, J.S. (author), Heringa, J. (author), 't Hoen, P.A.C. (author), Hooft, R. (author), Kuhn, T. (author), Kok, R. (author), Kok, J. (author), Lusher, S.J. (author), Martone, M.E. (author), Mons, A. (author), Packer, A.L. (author), Persson, B. (author), Rocca-Serra, P. (author), Roos, M. (author), van Schaik, R. (author), Sansone, S.A. (author), Schultes, E. (author), Sengstag, T. (author), Slater, T. (author), Strawn, G. (author), Swertz, M.A. (author), Thompson, M. (author), van der Lei, J. (author), van Mulligen, E. (author), Velterop, J. (author), Waagmeester, A. (author), Wittenburg, P. (author), Wolstencroft, K. (author), Zhao, J. (author), Mons, B. (author)
article 2019
Searched for: subject:"Biology"
(1 - 20 of 3,089)

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