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Pronk, A. (author), Loh, M. (author), Kuijpers, E. (author), Albin, M. (author), Selander, J. (author), Godderis, L. (author), Ghosh, M. (author), Vermeulen, R. (author), Peters, S. (author), Sivesind Mehlum, I. (author), Turner, M. (author), Schlunssen, V. (author), Goldberg, M. (author), Kogevinas, M. (author), Harding, B. (author), Solovieva, S. (author), Garani-Papadatos, T. (author), van Tongeren, M. (author), Stierum, R. (author)Exposures at work have a major impact on noncommunicable diseases (NCDs). Current risk reduction policies and strategies are informed by existing scientific evidence, which is limited due to the challenges of studying the complex relationship between exposure at work and outside work and health. We define the working life exposome as all...article 2022
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Steckling, N. (author), Gotti, A. (author), Bose-O'Reilly, S. (author), Chapizanis, D. (author), Costopoulou, D. (author), de Vocht, F. (author), Garí, M. (author), Grimalt, J.O. (author), Heath, E. (author), Hiscock, R. (author), Jagodic, M. (author), Karakitsios, S.P. (author), Kedikoglou, K. (author), Kosjek, T. (author), Leondiadis, L. (author), Maggos, T. (author), Mazej, D. (author), Polańska, K. (author), Povey, A. (author), Rovira, J. (author), Schoierer, J. (author), Schuhmacher, M. (author), Špirić, Z. (author), Stajnko, A. (author), Stierum, R. (author), Tratnik, J.S. (author), Vassiliadou, I. (author), Annesi-Maesano, I. (author), Horvat, M. (author), Sarigiannis, D.A. (author)Background: The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys – aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all...article 2018
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Ye, X. (author), Pierik, F.H. (author), Angerer, J. (author), Meltzer, H.M. (author), Jaddoe, V.W.V. (author), Tiemeier, H. (author), Hoppin, J.A. (author), Longnecker, M.P. (author), TNO Bouw en Ondergrond (author)Concerns about reproductive and developmental health risks of exposure to organophosphate (OP) pesticides, phthalates, and bisphenol A (BPA) among the general population are increasing. Six dialkyl phosphate (DAP) metabolites, 3,5,6-trichloro-2-pyridinol (TCPy), BPA, and fourteen phthalate metabolites were measured in 10 pooled urine samples...article 2009
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Noort, D. (author), van Zuylen, A. (author), Fidder, A. (author), van Ommen, B. (author), Hulst, A.G. (author), TNO Defensie en Veiligheid (author)Biomonitoring of exposure to the insecticide permethrin is usually performed by analysis of its urinary metabolites 3-phenoxybenzoic acid (3-PBA) or cis/trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (Cl2CA). We are engaged in the development of a methodology to assess the cumulative internal dose of exposure to...article 2008
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Engbers, L. (author), Sattelmair, J. (author)As a further step towards the implementation of the WHO Global Strategy on Diet, Physical Activity and Health (DPAS), WHO and the World Economic Forum organized a Joint Event (Dalian, China, September 2007) on the prevention of noncommunicable diseases (NCDs) in the workplace through healthy diets and physical activity. This paper provided the...report 2008
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Engbers, L. (author), Sattelmair, J. (author), TNO Kwaliteit van Leven (author)As a further step towards the implementation of the WHO Global Strategy on Diet, Physical Activity and Health (DPAS), WHO and the World Economic Forum organized a Joint Event (Dalian, China, September 2007) on the prevention of noncommunicable diseases (NCDs) in the workplace through healthy diets and physical activity. This paper provided the...book 2008
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Damsten, M.C. (author), Commandeur, J.N.M. (author), Fidder, A. (author), Hulst, A.G. (author), Touw, D. (author), Noort, D. (author), Vermeulen, N.P.E. (author), TNO Defensie en Veiligheid (author)Covalent binding of reactive electrophilic intermediates to proteins is considered to play an important role in the processes leading to adverse drug reactions and idiosyncratic drug reactions. Consequently, both for the discovery and the development of new drugs, there is a great interest in sensitive methodologies that enable the detection of...article 2007
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Noort, D. (author), Fidder, A. (author), van der Schans, M.J. (author), Hulst, A.G. (author), TNO Defensie en Veiligheid (author)We present a generic mass spectrometric method to verify exposure to organophosphates, based on the chemical conversion of the phosphylated peptides obtained after pepsin digestion of human butyrylcholinesterase (HuBuChE) to a common precursor peptide. After exposure of plasma to various organophosphates (nerve agents, pesticides), HuBuChE was...article 2006
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Prins Maurits Laboratorium TNO (author), van der Schans, M.J. (author), Polhuijs, M. (author), van Dijk, C. (author), Degenhardt, C.E.A.M. (author), Pleijsier, K. (author), Langenberg, J.P. (author), Benschop, H.P. (author)The utility was explored of a new approach to detect retrospectively exposure to nerve agents by means of conversion of the inhibitor moiety bound to the active site of the enzyme BuChE in plasma with fluoride ions into a phosphofluoridate which is subsequently analyzed by means of gas chromatography (GC). This quantifies ≥0.01% inhibition of...article 2004
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- Noort, D. (author), Fidder, A. (author), Hulst, A.G. (author), Prins Maurits Laboratorium TNO (author) article 2003
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Noort, D. (author), Benschop, H.P. (author), Black, R.M. (author), Prins Maurits Laboratorium TNO (author)In this report an overview of the methods currently available for detection of exposure to a number of chemical warfare agents (CWA), i.e., sulfur mustard, lewisite and nerve agents, is presented. Such methods can be applied for various purposes, e.g., diagnosis and dosimetry of exposure of casualties, confirmation of nonexposure, verification...article 2002
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Anderson, D. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO BIBRA (author)Butadiene (BD) and its 2-methyl analogue, isoprene, have been extensively studied in animals and BD in population studies. Both chemicals are metabolised by liver cytochrome P450 dependent monogenases to monoepoxide and diepoxide intermediates. The diepoxide intermediates of both compounds were mutagenic in Salmonella typhimurium. However,...article 2001
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van Delft, J.H.M. (author), Steenwinkel, M.-J.S.T. (author), van Asten, J.G. (author), de Vogel, N. (author), Bruijntjes-Rozier, T.C.D.M. (author), Schouten, T. (author), Cramers, P. (author), Maas, L. (author), van Herwijnen, M.H. (author), van Schooten, F.-J. (author), Hopmans, P.M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Occupational exposure to polycyclic aromatic hydrocarbons (PAH) increases the risk of developing lung cancer. Human exposure is often demonstrated by increased internal levels of PAH metabolites and of markers for early biological effects, like DNA adducts and cytogenetic aberrations. Objective: This study aimed to assess whether the current...article 2001
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Godschalk, R.W.L. (author), Moonen, E.J.C. (author), Schilderman, A.E.L. (author), Broekmans, W.M.R. (author), Kleinjans, J.C.S. (author), van Schooten, F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Understanding the kinetics of aromatic-DNA adducts in target tissues and white blood cells (WBC) would enhance the applicability of DNA adducts in WBC as surrogate source of DNA in biomonitoring studies. In the present study, rats were acutely exposed to benzo[a]pyrene (B[a]P; 10 mg/kg body wt) via intratracheal (i.t.), dermal and oral...article 2000
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Fidder, A. (author), Noort, D. (author), Hulst, A.G. (author), de Jong, L.P.A. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)The development of a procedure for retrospective detection and quantitation of exposure to the arsenical dichloro(2-chlorovinyl)arsine (lewisite; L1) has been initiated. Upon incubation of human blood with [14C]L1 (20 nM-0.2 mM) in vitro, more than 90% of the total radioactivity was found in the erythrocytes and 25-50% of the radioactivity...article 2000
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), Benford, D.J. (author), Cocker, J. (author), Sartorelli, P. (author), Schneider, T. (author), van Hemmen, J. (author), Firth, J.G. (author)To evaluate risk from dermal exposure, the amount of material on the skin must first be measured. The potential for dermal uptake must then be assessed for the potential health effects from systemic exposure. No standard methods exist for studying these processes, and published data are not comparable because of the different techniques used....article 1999
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van Delft, J.H.M. (author), Steenwinkel, M-J.S.T. (author), van Asten, J.G. (author), van Es, J. (author), Kraak, A. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)An investigation is presented of occupational exposure to polycyclic aromatic hydrocarbons (PAH) in a carbon-electrode manufacturing plant, as assessed by three monitoring methods, viz, environmental monitoring of the external dose by analysis of personal air samples, biological monitoring of the internal dose by analysis of urinary 1...article 1998
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Bos, P.M.J. (author), Brouwer, D.H. (author), Stevenson, H. (author), Hoogendoorn, L. (author), Boogaard, P.J. (author), de Kort, W.L.A.M. (author), van Hemmen, J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective. To evaluate two different techniques for assessing dermal exposure to 4,4'-methylene dianiline (MDA) in a field study. The results were used to test the applicability of a recently proposed quantitative dermal occupational exposure limit (DOEL) for MDA in a workplace scenario. Methods. For two consecutive weeks six workers were...article 1998
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), de Brabander, H.F. (author), de Wasch, K. (author), van Ginkel, L.A. (author), Sterk, S.S. (author), Blokland, M.H. (author), Delahaut, Ph. (author), Taillieu, X. (author), Dubois, M. (author), Arts, C.J.M. (author), van Baak, M.J. (author), Gramberg, L.G. (author), Schilt, R. (author), van Bennekom, E.O. (author), Courtheyn, D. (author), Vercammen, J. (author), Witkamp, R.F. (author)The European Union banned the use of anabolic steroids for cattle fattening in 1988. Analytical techniques able to detect trace amounts of the parent drugs and their metabolites are mandatory for the control of abuse. Stanozolol (Stan) is an anabolic steroid that is often found in injection sites and cocktails. However, it has never been...article 1998
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van Hemmen, J.J. (author), Brouwer, D.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The methods for the dermal exposure assessment vary in their complexity and are in some sense complementary to each other. The most easy-to-use methods involve a pseudo-skin-approach, such as gloves and removal by washing. In some cases generic modelling appears to be possible. The experimental methods can indicate and even quantitate the...article 1995
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