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Huebner, J.L. (author), Hanes, M.A. (author), Beekman, B. (author), TeKoppele, J.M. (author), Kraus, V.B. (author), Gaubius Instituut (author)Objective: To evaluate the interaction of bone and cartilage in knee osteoarthritis (OA) pathogenesis in two guinea-pig strains with appreciable differences in bone metabolism. Design: Two guinea-pig strains were evaluated for their susceptibilities to OA using semi-quantitative histological grading of knee joints and quantification of...article 2002
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de Groot, J. (author), Bank, R.A. (author), Tchetverikov, I. (author), Verzijl, N. (author), TeKoppele, J.M. (author), Gaubius Instituut (author)Osteoarthritis is a disabling joint disease that is characterized by the progressive destruction of articular cartilage. Diagnosis is based on clinical symptoms in combination with radiography, which is relatively insensitive and provides only an indication of accumulated damage. Alternative methods, such as molecular markers, are therefore...article 2002
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van den Brandt, P. (author), Voorrips, L. (author), Hertz-Picciotto, I. (author), Shuker, D. (author), Boeing, H. (author), Speijers, G. (author), Guittard, C. (author), Kleiner, J. (author), Knowles, M. (author), Wolk, A. (author), Goldbohm, A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)Epidemiologic studies directly contribute data on risk (or benefit) in humans as the investigated species, and in the full food intake range normally encountered by humans. This paper starts with introducing the epidemiologic approach, followed by a discussion of perceived differences between toxicological and epidemiologic risk assessment....article 2002
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), van den Berg, R. (author), Haenen, G.R.M.M. (author), van den Berg, H. (author), Bast, A. (author)There is increasing interest in the involvement of transcription factors, such as of the transcription factor NF-κB (nuclear factor-κB), in the pathogenesis of various diseases. NF-κB is involved in the control of the transcription of a variety of cellular genes that regulate the inflammatory response by the production of cytokines, chemokines,...article 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Verhagen, H. (author), Hageman, G.J. (author), Rauma, A.L. (author), de Versluis-Haan, G. (author), van Herwijnen, M.H.M. (author), de Groot, J. (author), Törrönen, R. (author), Mykkänen, H. (author)Allium vegetables (onions, leeks, chives) and in particular garlic have been claimed to have health-promoting potential. This study was conducted to get insight into the perspectives for monitoring the intake of garlic by a biomarker approach. Chemically, the bimarker results from exposure to gamma-glutamyl-S-allyl-L-cysteine, which is first...article 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Crews, H. (author), Alink, G. (author), Andersen, R. (author), Braesco, V. (author), Holst, B. (author), Maiani, G. (author), Ovesen, L. (author), Scotter, M. (author), Solfrizzo, M. (author), van den Berg, R. (author), Verhagen, H. (author), Williamson, G. (author)In this review many examples are given of the complexities involved in using some biomarkers in relation to assessing the effects of dietary exposure, when there is frequently a need to determine changes following long-term low level exposure to dietary components. These range from understanding why the biomarker might be valuable and how best...article 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Branca, F. (author), Hanley, A.B. (author), Pool-Zobel, B. (author), Verhagen, H. (author)Biomarkers have considerable potential in aiding the understanding of the relationship between diet and disease or health. However, to assess the role, relevance and importance of biomarkers on a case by case basis it is essential to understand and prioritise the principal diet and health issues. In the majority of cases, dietary compounds are...article 2001
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Bank, R.A. (author), Tekoppele, J.M. (author), Janus, G.J.M. (author), Wassen, M.H.M. (author), Pruijs, H.E.H. (author), van der Sluijs, H.A.H. (author), Sakkers, R.J.B. (author)The brittleness of bone in patients with osteogenesis imperfecta (OI) has been attributed to an aberrant collagen network. However, the role of collagen in the loss of tissue integrity has not been well established. To gain an insight into the biochemistry and structure of the collagen network, the cross-links hydroxylysylpyridinoline (HP) and...article 2000
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Griffiths, R. (author), Grieve, A. (author), Scollon, J. (author), Scott, M. (author), Williams, C. (author), Meredith, C. (author), TNO Kwaliteit van Leven TNO Bibra (author)Using primary cultures of mouse cerebellar granule cells as an in vitro model system, it has been demonstrated that different profiles of temporal expression of the c-fos proto-oncogene are observed under non-excitotoxic and excitotoxic conditions. A ratio has been derived previously for the steady- state level of c-fos mRNA after 30 min and 240...article 2000
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Yudkin, J.S. (author), Panahloo, A. (author), Stehouwer, C. (author), Emeis, J.J. (author), Bulmer, K. (author), Mohamed-Ali, V. (author), Denver, A.E. (author), Gaubius Instituut TNO (author)Aims/hypothesis. Improved glycaemic control might reduce both microvascular and macrovascular complications of Type II diabetes (non-insulin-dependent) mellitus. To explore such possible mechanisms, we investigated the effects of intensive treatment on markers of endothelial dysfunction and of acute phase activation, using both sulphonylureas...article 2000
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Anderson, D. (author), Phillips, B.J. (author), Yu, T-W. (author), Edwards, A.J. (author), Ayesh, R. (author), Butterworth, K.R. (author)Twenty-four men and 24 women, all nonsmoking, and maintaining normal dietary habits were assigned to 3 groups of 16. Each group comprising 4 males with "low" cholesterol levels (<6 mmol/L) matched for age and build with 4 males with "high" cholesterol levels (>6 mmol/L) and 8 similarly matched females. A three-treatment, three-treatment period,...article 2000
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Noort, D. (author), Hulst, A.G. (author), de Jong, L.P.A. (author), Benschop, H.P. (author)To develop a mass spectrometric assay for the detection of sulfur mustard adducts with human serum albumin, the following steps were performed: quantitation of the binding of the agent to the protein by using [14C] sulfur mustard and analysis of acidic and tryptic digests of albumin from blood after exposure to sulfur mustard for identification...article 1999
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Schalkwijk, C.G. (author), Poland, D.C.W. (author), van Dijk, W. (author), Kok, A. (author), Emeis, J.J. (author), Dräger, A.M. (author), Doni, A. (author), van Hinsbergh, V.W.M. (author), Stehouwer, C.D.A. (author), Gaubius instituut TNO (author)Moderately increased plasma concentrations of C-reactive protein are associated with an increased risk of cardiovascular disease, C-reactive protein, its relation to a low degree of inflammatory activation and its association with activation of the endothelium have not been systematically investigated in Type I (insulin-dependent) diabetes...article 1999
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van Puymbroeck, M. (author), Kuilman, M.E.M. (author), Maas, R.F.M. (author), Witkamp, R.F. (author), Leyssens, L. (author), van Miert, A.S.J.P.A.M. (author), Hendriks, L. (author), van der Zande, D.J.M. (author), Adriaensens, P. (author), Jacobs, M.-P. (author), Raus, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The metabolism of the illegal growth promoter ethylestrenol (EES) was evaluated in bovine liver cells and subcellular fractions of bovine liver preparations. Incubations with bovine microsomal preparations revealed that EES is extensively biotransformed into norethandrolone (NE), another illegal growth promoter. Furthermore, incubations of...article 1999
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- Feron, V.J. (author), Schwarz, M. (author), Hemminki, K. (author), Krewski, D. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1999
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Schalkwijk, C.G. (author), Ligtvoet, N. (author), Twaalfhoven, H. (author), Jager, A. (author), Blaauwgeers, H.G.T. (author), Schlingemann, R.O. (author), Tarnow, L. (author), Parving, H.H. (author), Stehouwer, C.D.A. (author), van Hinsbergh, V.W.M. (author), Gaubius instituut TNO (author)Nonenzymatic glycation is increased in diabetes. Most studies so far have focused on the role of advanced glycation end products (AGEs) in vascular complications, whereas the role of early glycation Amadori-modified proteins, which is the predominant form of glycated proteins, has not been systemically investigated in humans. We developed an...article 1999
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de Valk-de Roo, G.W. (author), Stehouwer, C.D.A. (author), Meijer, P. (author), Mijatovic, V. (author), Kluft, C. (author), Kenemans, P. (author), Cohen, F. (author), Watts, S. (author), Netelenbos, C. (author), Gaubius instituut TNO (author)Currently raloxifene, a selective estrogen receptor modulator, is being investigated as a potential alternative for postmenopausal hormone replacement to prevent osteoporosis and cardiovascular disease. We compared the 2-year effects of raloxifene on a wide range of cardiovascular risk factors with those of placebo and conjugated equine...article 1999
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Sanz-Gallardo, M.I. (author), Guallar, E. (author), van 't Veer, P. (author), Longnecker, M.P. (author), Strain, J.J. (author), Martin, B.C. (author), Kardinaal, A.F.M. (author), Fernández-Crehuet, J. (author), Thamm, M. (author), Kohlmeier, L. (author), Kok, F.J. (author), Martín-Moreno, J.M. (author)To identify the determinants of p,p'-dichlorodiphenyldichloroethane (p,p'-DDE) in adipose tissue in subjects who participated in a cross- sectional study, we analyzed fatty acids, antioxidants, and p,p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p,p'-DDE concentration was 1.66 μg...article 1999
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Su, L.C.J. (author), Bui, M. (author), Kardinaal, A. (author), Gomez-Aracena, J. (author), Martin-Moreno, J. (author), Martin, B. (author), Thamm, M. (author), Simonsen, N. (author), van 't Veer, P. (author), Kok, F. (author), Strain, S. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Biomarkers of dietary exposure or nutritional status are sought actively to overcome limitations of traditional dietary methodology. We compared plasma and adipose tissue biomarkers for carotenoids and tocopherols. The data consisted of samples from 91 men and 122 women, ages 45-70 years, from the control group of the European Community...article 1998
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Ronday, H.K. (author), TeKoppele, J.M. (author), Greenwald, R.A. (author), Moak, S.A. (author), de Roos, J.A.D.M. (author), Dijkmans, B.A.C. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)The plasminogen activation system is one of the enzyme systems held responsible for bone and cartilage degradation in rheumatoid arthritis (RA). In this study, we evaluated the effect of tranexamic acid (TEA), an inhibitor of plasminogen activation, on urinary collagen cross-link excretion and radiological joint damage in rat adjuvant arthritis ...article 1998