Searched for: subject:"Barriers"
(1 - 20 of 113)

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van Helden, H.P.M. (author), de Lange, J. (author), Busker, R.W. (author), Melchers, B.P.C. (author), Medisch Biologisch Laboratorium TNO (author)
Isolated rat diaphragm preparations treated with soman or with the irreversible and oxime resistant cholinesterase (ChE) inhibitor S27 (see Compounds) showed a considerable recovery of neuromuscular transmission (NMT) during incubation with the (bis)pyridinium oximes HI-6, HGG-12, P2S and obidoxime. In the soman-treated preparations this NMT...
article 1991
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Prins Maurits Laboratorium TNO (author), Absil, L.H.J. (author), Kodde, H.H. (author), Weerheijm, J. (author)
Noise pollution around military training facilities caused by firing of explosives, artillery or large caliber guns poses a severe problem to neighbouring communities. One possible way to attenuate the blast is the construction of blast walls close to the explosion center. This paper describes a combined experimental and numerical study of the...
conference paper 1995
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Dulfer, W.J. (author), Groten, J.P. (author), Govers, H.A.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Polychlorinated biphenyls (PCBs) dissolved in dietary fat are absorbed in the gastrointestinal tract by the enterocytes in combination with the fatty acid proceeding from the lipid hydrolysis in the gut lumen. The effect of fatty acid absorption on the uptake and transport of 14 PCBs in enterocytes was studied using monolayers of the human...
article 1996
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van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
The pathogenesis of multiple sclerosis (MS), the major neurological disease of young adults in the Western world, is still poorly understood, and no effective therapy to block MS is available as yet. The clinical symptoms of MS result from inflammatory damage to the insulating myelin sheath of axons in the CNS and - at later stages - to axons...
article 1996
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Nijssen, B. (author), Kamperman, T. (author), Jetten, J. (author), TNO Voeding (author)
The use of PET bottles for packaging soft drinks and mineral waters is still growing world wide. The production process for these bottles is improving constantly. These improvements are focussed on bottles with better barrier properties, higher inertness and higher heat stability. One of the factors determining the quality of PET bottles is the...
article 1996
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de Coo, P.J.A. (author), Roberts, A. (author), Seeck, A. (author), Cesari, D. (author)
Side-impact safety of passenger cars is assessed in Europe in a full-scale test using a moving barrier. The front of this barrier is deformable and represents the stiffness of an 'average' car. The EU Directive 96/27/EC on side impact protection has adopted the EEVC Side Impact Test Procedure, including the original performance specification for...
conference paper 1998
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Rijnaarts, H.H.M. (author), van Aalst-van Leeuwen, M.A. (author), van Heiningen, E. (author), van Buyzen, H. (author), Sinke, A. (author), van Liere, H.C. (author), Harkes, M. (author), Baartmans, R. (author), Bosma, T.N.P. (author), Doddema, H.J. (author), TNO Milieu, Energie en Procesinnovatie (author)
The feasibility of intrinsic and enhanced bioremediation approaches for 16 contaminated sites in the Netherlands are discussed. At at least five out of 10 chlorinated solvent sites, natural attenuation can be used as one of the tools to prevent further dispersion of the plume. At two sites stimulation of the intrinsic dechlorination processes in...
conference paper 1998
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Laman, J.D. (author), Maassen, C.B.M. (author), Schellekens, M.M. (author), Visser, L. (author), Kap, M. (author), de Jong, E. (author), van Puijenbroek, M. (author), van Stipdonk, M.J.B. (author), van Meurs, M. (author), Schwärzler, C. (author), Günthert, U. (author), TNO Preventie en Gezondheid (author)
Interactions between mononuclear cells are required for the formation of inflammatory infiltrates in the CNS and the activation of cellular effector functions provoking demyelination in MS. Membrane-expressed costimulatory molecules are crucial to such interactions. We therefore investigated whether two costimulatory molecules, CD40L (CD154,...
article 1998
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Huibers, J.A.H.M. (author), Faerber, E. (author), Cesari, D. (author), Hobbs, A.C. (author), van Kampen, B. (author), Paez, J. (author), Wykes, N.J. (author), TNO Wegtransportmiddelen (author)
This paper will provide an overview of the research work of the European Enhanced Vehicle-safety Committee (EEVC) in the field of crash compatibility between passenger cars. Since July 1997 the EC Commission is partly funding the research work of EEVC. The running period of this project will be two years. The progress of five working packages of...
conference paper 1998
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Mugnai, A. (author), Burke, G. (author), TNO Wegtransportmiddelen TNO-MADYMO North America DaimlerChrysler Corp. (author)
In 1996, the European Community released new regulations relating to frontal impact vehicle crash. One of the tests, the European offset crash, consists of crashing the car on a deformable barrier at 56 km/h with 40% of the car impacting on the barrier. The regulations require the dummy injury parameters such as the HIC, chest deflection, chest...
conference paper 2000
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Bajramović, J.J. (author), Plomp, A.C. (author), van der Goes, A. (author), Koevoets, C. (author), Newcombe, J. (author), Cuzner, M.L. (author), van Noort, J.M. (author)
In the development of multiple sclerosis (MS), (re)activation of infiltrating T cells by myelin-derived Ags is considered to be a crucial step. Previously, αB-crystallin has been shown to be an important myelin Ag to human T cells. Since αB-crystallin is an intracellular heat shock protein, the question arises at what stage, if any, during...
article 2000
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Merkel, P. (author), Weiβ, H. (author), Teutsch, G. (author), Rijnaarts, H.H.M. (author), TNO Milieu, Energie en Procesinnovatie (author)
At many industrial sites inadequate waste disposal, leakages and war damages have led to severe groundwater contamination on a regional scale. Standard hydraulic groundwater remediation methods, such as pump-and-treat, in most cases do not lead to satisfactory results, due to the persistence of organic contaminants and the resulting very long...
conference paper 2000
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Beets, D.J. (author), van der Spek, A.J.F. (author), Nederlands Instituut voor Toegepaste Geowetenschappen TNO (author)
Flooding of the southern part of the North Sea occurred between 9000 and 8000 BP, when the rate of relative sea-level rise was on the order of 0.7 cm per year for the Dover Strait Region and 1.6 cm per year for the area north of the Frisian Islands, forcing the shoreline to recede rapidly. When relative sea-level rise decelerated after 7000 BP...
article 2000
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de Gans, W. (author), Beets, D.J. (author), Centineo, M.C. (author), Nederlands Instituut voor Toegepaste Geowetenschappen TNO (author)
During its maximum extension, the Saalian ice cap reached into the central Netherlands, where glacier tongues excavated over 100 m deep basins in the unconsolidated Middle and Early Pleistocene sediments. The basins are filled by relatively thick successions of Late Saalian, Eemian and Weichselian sediments. The fill of the Amsterdam glacial...
article 2000
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Langenhoff, A.A.M. (author), Staps, J.J.M. (author), Pijls, C. (author), Alphenaar, A. (author), Zwiep, G. (author), Rijnaarts, H.H.M. (author), TNO Milieu, Energie en Procesinnovatie (author)
The pollution of soil and groundwater with hexachlorocyclohexane (HCH) has caused serious environmental problems. Mineralisation of some HCH isomers can be expected under aerobic conditions whereas all isomers are known to be bioconverted to intermediate products under anaerobic conditions. Hence, redox conditions can be expected to have strong...
conference paper 2000
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Ponec, M. (author), Gibbs, S. (author), Pilgram, G. (author), Boelsma, E. (author), Koerten, H. (author), Bouwstra, J. (author), Mommaas, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
One of the prerequisites for the use of human skin equivalents for scientific and screening purposes is that their barrier function is similar to that of native skin. Using human epidermis reconstructed on de-epidermized dermis we demonstrated that the formation of the stratum corneum (SC) barrier in vitro proceeds similarly as in vivo as judged...
article 2001
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Magos, L. (author), TNO BIBRA International Ltd, Woodmansterne Rd, Carshalton, Surrey SM5 4DS, United Kingdom Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Chemicals/CAS: Biological Products; Ethylmercury Compounds; Food Additives; Pharmaceutical Preparations; Preservatives, Pharmaceutical; Thimerosal, 54-64-8
article 2001
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Huibers, J. (author), de Beer, E. (author), TNO Wegtransportmiddelen (author)
EuroNCAP tests are carried out since 1997. The test procedure in general is comparable to the EC Directive 96/79 with a test speed of 64 km/h. This increased test speed implies a higher frontal stiffness for new vehicle designs in order to achieve a high ranking. This frontal stiffness is one of the major factors for compatibility in car to car...
conference paper 2001
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Ponec, M. (author), Gibbs, S. (author), GPilgram, G. (author), BoeIsma, E. (author), Koerten, H. (author), Bouwstra, J. (author), Mommaas, M. (author), TNO Voeding (author)
One of the prerequisitesforthe use of human skin equivalents for scientific and screening purposes is that their barrierfunction is similar to that of native skin. Using human epidermis reconstructed en de-epidermized dermis we demonstrated that the formation of the stratum corneum (SC) barrier in vitro proceeds similarly as in vivo as judged...
article 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Spreeuwenberg, M.A.M. (author), Verdonk, J.M.A.J. (author), Gaskins, H.R. (author), Verstegen, M.W.A. (author)
Compromising alterations in gastrointestinal architecture are common during the weaning transition of pigs. The relation between villous atrophy and epithelial barrier function at weaning is not well understood. This study evaluated in vitro transepithelial transport by Ussing metabolic chambers, local alterations in T-cell subsets and villous...
article 2001
Searched for: subject:"Barriers"
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