Searched for: subject:"Barriers"
(1 - 13 of 13)
document
Weening-Verbree, L.F. (author), Schuller, A.A. (author), Cheung, S.L. (author), Zuidema, S.U. (author), van der Schans, C.P. (author), Hobbelen, J.S.M.H. (author)
Objectives to explore attitudes, perceptions, and perceived barriers to and the perceived facilitators of daily oral health care and the actual daily oral health care performances among nursing home staff. Methods A mixed methods study in 21 nursing homes was completed; a) questionnaires for nursing staff and managers; b) focus group interviews...
article 2021
document
van den Heuvel, S. (author), Bakhuys Roozeboom, M.M.C. (author), Eekhout, I. (author), Venema, A. (author)
This report examines barriers to and drivers of workplace psychosocial risk management, and how this is influenced by different national and organisational contexts. The exposure of workers to psychosocial risks is increasing. However, the level of risk and the effectiveness of management vary across sectors and countries. Based on the findings...
report 2018
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Willson, M.L. (author), Vernooij, R.W.M. (author), Gagliardi, A.R. (author), Armstrong, M. (author), Bernhardsson, S. (author), Brouwers, M. (author), Bussières, A. (author), Fleuren, M.A.H. (author), Gali, K. (author), Huckson, S. (author), Jones, S. (author), Lewis, S.Z. (author), James, R. (author), Marshall, C. (author), Mazza, D. (author)
Objective This study described the number and characteristics of questionnaires used to assess barriers of guideline use among physicians. Study Design and Setting A scoping review was conducted. MEDLINE and EMBASE were searched from 2005 to June 2016. English-language studies that administered a questionnaire to assess barriers of guideline use...
article 2017
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van den Heuvel, S. (author), Bakhuys Roozeboom, M.M.C. (author), Eekhout, I. (author), Houtman, I.L.D. (author)
Management of psychosocial risks in European workplaces; drivers and barriers in a national and cultural context. General objective of the project commissioned by the European Agency for Safety and Health at Work (EU-OSHA) is to support policy makers in stimulating successful psychosocial risk (PSR) management. Since the national and cultural...
public lecture 2017
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Raaphorst, R.M. (author), Savolainen, H. (author), Cantore, M. (author), van de Steeg, E. (author), van Waarde, A. (author), Colabufo, N.A. (author), Elsinga, P.H. (author), Lammertsma, A.A. (author), Windhorst, A.D. (author), Luurtsema, G. (author)
Positron emission tomography (PET) imaging of P-glycoprotein (P-gp) in the blood-brain barrier can be important in neurological diseases where P-gp is affected, such as Alzheimer’s disease. Radiotracers used in the imaging studies are present at very small, nanomolar, concentration, whereas in vitro assays where these tracers are characterized,...
article 2017
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Westerhout, J. (author), Wortelboer, H. (author), Verhoeckx, K. (author)
The Ussing chamber system is named after the Danish zoologist Hans Ussing, who invented the device in the 1950s to measure the short-circuit current as an indicator of net ion transport taking place across frog skin (Ussing and Zerahn, Acta Physiol Scand 23:110-127, 1951). Ussing chambers are increasingly being used to measure ion transport in...
bookPart 2015
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Schiffelers, M.J.W.A. (author), Blaauboer, B.J. (author), Bakker, W.E. (author), Hendriksen, C.F.M. (author), Krul, C. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The two-generation study (OECD TG 416) is the standard requirement within REACH to test reproductive toxicity effects of chemicals with production volumes >100. tonnes. This test is criticized in terms of scientific relevance and animal welfare. The Extended One Generation Reproductive Toxicity Study (EOGRTS), incorporated into the OECD test...
article 2015
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Vlaming, M.L.H. (author), Läppchen, T. (author), Jansen, H.T. (author), Kivits, S. (author), van Driel, A. (author), van der Steeg, E. (author), van der Hoorn, J.W. (author), Sio, C.F. (author), Steinbach, O.C. (author), de Groot, J. (author)
Introduction: The efflux transporters P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) are expressed at the blood-brain barrier (BBB), and can limit the access of a wide range of drugs to the brain. In this study we developed a PET-CT imaging method for non-invasive, quantitative analysis of the effect of ABCB1 and...
article 2015
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Vogt, L.M. (author), Meyer, D. (author), Pullens, G. (author), Faas, M.M. (author), Venema, K. (author), Ramasamy, U. (author), Schols, H.A. (author), de Vos, P. (author)
Dietary fiber intake is associated with lower incidence and mortality from disease, but the underlying mechanisms of these protective effects are unclear.We hypothesized that β2→1-fructan dietary fibers confer protection on intestinal epithelial cell barrier function via Toll-like receptor 2 (TLR2), and we studied whether β2→1-fructan chain...
article 2014
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Westerhout, J. (author)
In the development of drugs for the treatment of central nervous system (CNS) disorders, the prediction of human CNS drug action is a big challenge. Direct measurement of brain extracellular fluid (brainECF) concentrations is highly restricted in human. Therefore, unbound drug concentrations in human cerebrospinal fluid (CSF) are used as a...
doctoral thesis 2014
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Joosen, M.J.A. (author), van der Schans, M.J. (author), van Dijk, C.G.M. (author), Kuijpers, W.C. (author), Wortelboer, H.M. (author), van Helden, H.P.M. (author)
One of the shortcomings of current treatment of nerve agent poisoning is that oximes hardly penetrate the blood-brain barrier (BBB), whereas nerve agents easily do. Increasing the concentration of oximes in the brain, would therefore provide an attractive approach to improve medical countermeasures. An explanation for limited penetration might...
article 2011
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de Koning, M.C. (author), van Grol, M. (author), Noort, D. (author)
Commonly employed pyridinium-oxime (charged) reactivators of nerve agent inhibited acetylcholinesterase (AChE) do not readily pass the blood brain barrier (BBB) because of the presence of charge(s). Conversely, non-ionic oxime reactivators often suffer from a lack of reactivating potency due to a low affinity for the active site of AChE. It was...
article 2011
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Ponec, M. (author), Gibbs, S. (author), GPilgram, G. (author), BoeIsma, E. (author), Koerten, H. (author), Bouwstra, J. (author), Mommaas, M. (author), TNO Voeding (author)
One of the prerequisitesforthe use of human skin equivalents for scientific and screening purposes is that their barrierfunction is similar to that of native skin. Using human epidermis reconstructed en de-epidermized dermis we demonstrated that the formation of the stratum corneum (SC) barrier in vitro proceeds similarly as in vivo as judged...
article 2001
Searched for: subject:"Barriers"
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