Searched for: subject:"Barriers"
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van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
The pathogenesis of multiple sclerosis (MS), the major neurological disease of young adults in the Western world, is still poorly understood, and no effective therapy to block MS is available as yet. The clinical symptoms of MS result from inflammatory damage to the insulating myelin sheath of axons in the CNS and - at later stages - to axons...
article 1996
Bajramović, J.J. (author), Plomp, A.C. (author), van der Goes, A. (author), Koevoets, C. (author), Newcombe, J. (author), Cuzner, M.L. (author), van Noort, J.M. (author)
In the development of multiple sclerosis (MS), (re)activation of infiltrating T cells by myelin-derived Ags is considered to be a crucial step. Previously, αB-crystallin has been shown to be an important myelin Ag to human T cells. Since αB-crystallin is an intracellular heat shock protein, the question arises at what stage, if any, during...
article 2000