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Onder, S. (author), van Grol, M. (author), Fidder, A. (author), Xiao, G. (author), Noort, D. (author), Yerramalla, U. (author), Tacal, O. (author), Schopfer, L.M. (author), Lockridge, O. (author)Chronic low-dose exposure to organophosphorus pesticides is associated with the risk of neurodegenerative disease. The mechanism of neurotoxicity is independent of acetylcholinesterase inhibition. Adducts on tyrosine, lysine, threonine, and serine can occur after exposure to organophosphorus pesticides, the most stable being adducts on tyrosine....article 2021
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Kuper, C.F. (author), van Bilsen, J. (author), Wijnands, M.V.W. (author)The thoracic cavities receive increasing attention in toxicology, because inhaled fibers and (nano)particles can reach these cavities and challenge the local lymphoid tissues. The thoracic and abdominopelvic cavities are controlled by the serosal immune system with its special, loosely organized lymphoid clusters, namely the fat-associated...article 2018
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Vogt, L.M. (author), Meyer, D. (author), Pullens, G. (author), Faas, M.M. (author), Venema, K. (author), Ramasamy, U. (author), Schols, H.A. (author), de Vos, P. (author)Dietary fiber intake is associated with lower incidence and mortality from disease, but the underlying mechanisms of these protective effects are unclear.We hypothesized that β2→1-fructan dietary fibers confer protection on intestinal epithelial cell barrier function via Toll-like receptor 2 (TLR2), and we studied whether β2→1-fructan chain...article 2014
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Lindeman, J.H.N. (author), Abdul-Hussien, H. (author), Schaapherder, A.F.M. (author), van Bockel, J.H. (author), von der Thüsen, J.H. (author), Roelen, D.L. (author), Kleemann, R. (author)Inflammation plays a key role in the pathogenesis of an AAA (abdominal aortic aneurysm); however, the nature of the inflammatory factors and cellular response(s) involved in AAA growth is controversial. In the present study, we set out to determine the aortic levels of inflammatory cytokines in relation to downstream inflammatory transcription...article 2008
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van Wijk, F. (author), Knippels, L. (author), TNO Kwaliteit van Leven (author)Immediately after birth the mucosa of the gastrointestinal tract, which represents the greatest body surface area exposed to the outside environment, is confronted with a large variety of foreign antigens. The immune system of the intestine now has to meet the task of discriminating between pathogens and harmless antigens, such as food proteins...article 2007
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Nagelkerken, L. (author), Haspels, I. (author), van Rijs, W. (author), Blauw, B. (author), Ferrant, J.L. (author), Hess, D.M. (author), Garber, E.A. (author), Taylor, F.R. (author), Burkly, L.C. (author), Gaubius Instituut TNO (author)It has been demonstrated that anti-CD154 mAb treatment effectively inhibits the development of experimental autoimmune encephalomyelitis (EAE). However, although it appears to prevent the induction of Th1 cells and reactivation of encephalitogenic T cells within the CNS, little information is available regarding the involvement of alternative...article 2004
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van Stipdonk, M.J.B. (author), Willems, A.A. (author), Verbeek, R. (author), Boog, C.J.P. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)The myelin-associated stress protein αB-crystallin triggers strong proliferative responses and IFN-γ production by human T cells and it is considered a candidate autoantigen in multiple sclerosis. In this study we examined the capacity of αB-crystallin or peptides derived thereof to induce experimental autoimmune encephalomyelitis (EAE) in SJL...article 2000
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Dormans, J.A.M.A. (author), Steerenberg, P.A. (author), Arts, J.H.E. (author), van Bree, L. (author), de Klerk, A. (author), Verlaan, A.P.J. (author), Bruijntjes, J.P. (author), Beekhof, P. (author), van Soolingen, D. (author), van Loveren, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In this study the effects of inhalatory exposure to coal fly ash on lung pathology and the immune system in rats were examined. Rats were exposed to 0, 10, 30, or 100 mg/m3 coal fly ash (6 h/day, 5 days/wk) for 4 wk, or to 0 and 100 mg/m3 for 1 wk, and for 1 wk followed by a recovery in clean air of 3 wk. A concentration-related increase in lung...article 1999
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TNO Preventie en Gezondheid (author), van Sechel, A.C. (author), Bajramovic̀, J.J. (author), van Stipdonk, M.J.B. (author), Persoon-Deen, C. (author), Geutskens, S.B. (author), van Noort, J.M. (author)The development of multiple sclerosis is most likely influenced by autoimmune responses to central nervous system myelin proteins as well as by infections with common viruses such as EBV and human herpesvirus-6. However, much remains to be established on how these factors interact. In this study, we show that upon EBV infection, human B cells...article 1999
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Zhu, D. (author), van Arkel, C. (author), King, C.A. (author), van Meirvenne, S. (author), de Greef, C. (author), Thielemans, K. (author), Radl, J. (author), Stevenson, F.K. (author), TNO Preventie en Gezondheid (author)The 5T series of multiple myelomas (MM) and Waldenstrsom's macroglobulinaemia-like lymphomas (WM), which developed spontaneously in ageing mice of the C57BL/KaLwRij strain, shows clinical and biological features that closely resemble their corresponding human diseases. In order to compare the patterns of somatic mutation in V(H) genes of mouse...article 1998
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Chua-Intra, B. (author), Ivanyi, J. (author), Hills, A. (author), Thole, J. (author), Moreno, C. (author), Vordermeier, H.M. (author), TNO Preventie en Gezondheid (author)The Mycobacterium leprae and M. tuberculosis 10000 MW heat-shock protein homologues of GroES have previously been identified as major immunogens for human T cells. We used synthetic peptides to characterize the determinants recognized by murine T cells. The findings suggest that, despite 90% sequence identity between these two proteins, T cells...article 1998
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Vyth-Dreese, F.A. (author), Boot, H. (author), Dellemijn, T.A.M. (author), Majoor, D.M. (author), Oomen, L.C.J.M. (author), Laman, J.D. (author), van Meurs, M. (author), de Weger, R.A. (author), de Jong, D. (author), TNO Preventie en Gezondheid (author)Costimulatory molecules are essential in cognate interactions between T and B lymphocytes. To study the prerequisites of functional interactions between malignant B cells and intermingled T cells in B-cell non-Hodgkin's lymphomas (B-NHL), we examined the expression of CD40, CD80 and CD86 and their ligands CD40 ligand (CD40L, CD154), CD28 and...article 1998
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TNO Preventie en Gezondheid (author), Chargelegue, D. (author), Obeid, O.E. (author), Hsu, S.C. (author), Shaw, M.D. (author), Denbury, A.N. (author), Taylor, G. (author), Steward, M.W. (author)Respiratory syncytial virus (RSV) is the most important cause of bronchiolitis and pneumonia in infants and young children worldwide. As yet, there is no effective vaccine against RSV infection, and previous attempts to develop a formalin-inactivated vaccine resulted in exacerbated disease in recipients subsequently exposed to the virus. In the...article 1998
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Laman, J.D. (author), Claassen, E. (author), Noelle, R.J. (author), TNO Preventie en Gezondheid (author)Initially, a role for the interaction between CD40, expressed on B cells, and gp39 (CD40L), expressed on activated T cells, has been defined in humoral immunity. CD40-CD40L interaction is an essential signal for B cell proliferation, expression of activation markers, immunoglobulin production, and isotype switching. CD40-CD40L interaction is...article 1996
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Gaubius Instituut TNO (author), Gerritse, K. (author), Laman, J.D. (author), Noelle, R.J. (author), Aruffo, A. (author), Ledbetter, J.A. (author), Boersma, W.J.A. (author), Claassen, E. (author)We investigated the role of CD40-CD40 ligand (CD40L) interactions in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). Activated helper T cells expressing CD40L (gp39) surface protein were found in MS patient brain sections, but not in brain tissue sections of normal controls or patients with other neurological diseases....article 1996
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Dobber, R. (author), Tielemans, M. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)In the present study we investigated whether age-related changes in the composition and functional properties of murine CD4+ T cells are reflected in vivo by a changed humoral response to influenza vaccine in aged mice. After the primary immunization, the titers of influenza-specific IgM, IgG1, IgG2a, and IgG2b, but not of IgG3 and IgE, were...article 1995
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Claassen, I.J.T.M. (author), Osterhaus, A.D.M.E. (author), Claassen, E. (author), Gaubius Instituut TNO (author)Several mechanisms have been postulated to explain the relatively high immunogenicity of antigens presented in immune-stimulating complexes (iscom). Their potency can in part be explained by the specific targeting of these structures to cells presenting antigens to the immune system. However, until now no method for the subcellular detection of...article 1995
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Foy, T.M. (author), Laman, J.D. (author), Ledbetter, J.A. (author), Aruffo, A. (author), Claassen, E. (author), Noelle, R.J. (author), Medisch Biologisch Laboratorium TNO (author)gp39, the ligand for CD40 expressed on activated CD4+ T helper cells, is required for the generation of antibody responses to T-dependent (TD) antigens. Treatment of mice with anti-gp39 in vivo inhibits both primary and secondary antibody formation to TD, but not T-independent antigens. However, the role of this receptor-ligand pair in the...article 1994
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van den Eertwegh, A.J.M. (author), Boersma, W.J.A. (author), Claassen, E. (author), Medisch Biologisch Laboratorium TNO (author)The spleen is an important lymphoid organ, involved in immune responses against all types of antigen that appear in the circulation. Its complex anatomical organization, with distinct compartments containing specialized cell types, provides a microenvironment which allows different cell-cell interactions and determines the direction of...article 1992
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- Claassen, E. (author), Gerritse, K. (author), Laman, J.D. (author), Boersma, W.J.A. (author), Medisch Biologisch Laboratorium TNO (author) article 1992
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