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Markus, C.R. (author), Lammers, J.H.C.M. (author)Extracts from the leaves of the Ginkgo biloba tree (GBE) are found to be clinically effective in neuroprotection, cerebral and cardiovascular function and cognitive processing. Recent animal findings suggest that GBE also may improve stress adaptation and prevent learned helplessness, as evidenced by its reduction of behavioral acquisition...article 2003
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Prins Maurits Laboratorium TNO (author), Philippens, I.H.C.H.M. (author), Busker, R.W. (author), Wolthuis, O.L. (author), Olivier, B. (author), Bruijnzeel, P.L.B. (author), Melchers, B.P.C. (author)The behavioral and neurophysiological effects of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic antagonist scopolamine (SCO) (0.018 mg/kg/h) were determined in guinea pigs. In contrast to a single injection of PHY, subchronic application by osmotic minipumps...article 1998
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Philippens, I.H.C.H.M. (author), Melchers, B.P.C. (author), de Groot, D.M.G. (author), Wolthuis, O.L. (author)It is known that rats poisoned with near-lethal doses of pinacolyl methylphosphonofluoridate (soman) develop brain lesions, particularly when convulsions are induced. When rats were intoxicated with a LD50 of soman and treated immediately thereafter with a combination of low doses of atropine and diazepam (LOW AS/DZ treatment), large decrements...article 1992
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Philippens, I.H.C.H.M. (author), Melchers, B.P.C. (author), Wolthuis, O.L. (author)Behavioral training of guinea pigs by conventional methods, such as used for rats and mice, appears difficult. Hence, only a few behavioral experiments with guinea pigs have been described in the literature. An active avoidance technique in an automated two-way shuttlebox is described using sound as a conditioned (CS) and a tactile stimulus (a...article 1992
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Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)The effects of etiracetam, a structural analogue or piracetam, were investigated in rats on Y-maze discrimination acquisition, on open field behavior, on one-trial passive avoidance learning and on shuttlebox acquisition and extinction. The results indicate that this drug significantly enhances acquisition and may improve retention without...article 1981